Survival and cancer risk in an unselected and complete Norwegian idiopathic inflammatory myopathy cohort

Dobloug, Gerd Cecilie; Garen, Torhild; Brunborg, Cathrine; Gran, Jan Tore; Molberg, Øyvind

doi:10.1016/j.semarthrit.2015.06.005

Cited by 83 publications

(69 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One of the latest studies, which is the largest population-based IIM mortality study to date, compared death rates in 326 Norwegian patients with IIM diagnosed between 2003 and 2012 in southern parts of Norway, with death rates in the general population. In that study, a standardised mortality ratio of 2.4/2.6/1.7 in PM/DM/sIBM was reported 20. Unfortunately, incidence rates of death and timing of death risk in relation to IIM diagnosis was not assessed.…”

Section: Introductionmentioning

confidence: 95%

Mortality in idiopathic inflammatory myopathy: results from a Swedish nationwide population-based cohort study

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 95%

Mortality in idiopathic inflammatory myopathy: results from a Swedish nationwide population-based cohort study

et al. 2017

Self Cite

View full text Add to dashboard Cite

show abstract

“… 25–30 Eleven by 20 (55%) of the deaths were due to cardiac aetiology in a Hungarian longitudinal study, 26 36% of 149 deaths were due to circulatory causes (not further specified) in a register-based Finnish study, whereas 12/87 (14%) deaths were due to cardiac causes in a recent population-based Norwegian study. 31 Also, in retrospective follow-up studies on patients with PM and DM, cardiac disease was one of the four most frequent causes of death. 32 33 The discrepancies between the studies regarding aetiology of deaths may be due to variable study designs and populations, variable definitions of cardiac involvement, limited numbers of patients in some of the series and studies performed at different time periods and decades.…”

Section: Cardiac Mortalitymentioning

confidence: 99%

“…However, the patients with IBM were older (66.9 (0.9) versus 53.2 (1.5) years). 31 To the best of our knowledge, no studies address the relationship between JDM and coronary artery disease.…”

Section: Clinical Heart Involvementmentioning

confidence: 99%

Cardiac involvement in adult and juvenile idiopathic inflammatory myopathies

et al. 2016

View full text Add to dashboard Cite

Idiopathic inflammatory myopathies (IIM) include the main subgroups polymyositis (PM), dermatomyositis (DM), inclusion body myositis (IBM) and juvenile DM (JDM). The mentioned subgroups are characterised by inflammation of skeletal muscles leading to muscle weakness and other organs can also be affected as well. Even though clinically significant heart involvement is uncommon, heart disease is one of the major causes of death in IIM. Recent studies show an increased prevalence of traditional cardiovascular risk factors in JDM and DM/PM, which need attention. The risk of developing atherosclerotic coronary artery disease is increased twofold to fourfold in DM/PM. New and improved diagnostic methods have in recent studies in PM/DM and JDM demonstrated a high prevalence of subclinical cardiac involvement, especially diastolic dysfunction. Interactions between proinflammatory cytokines and traditional risk factors might contribute to the pathogenesis of cardiac dysfunction. Heart involvement could also be related to myocarditis and/or myocardial fibrosis, leading to arrhythmias and congestive heart failure, demonstrated both in adult and juvenile IIM. Also, reduced heart rate variability (a known risk factor for cardiac morbidity and mortality) has been shown in long-standing JDM. Until more information is available, patients with IIM should follow the same recommendations for cardiovascular risk stratification and prevention as for the corresponding general population, but be aware that statins might worsen muscle symptoms mimicking myositis relapse. On the basis of recent studies, we recommend a low threshold for cardiac workup and follow-up in patients with IIM.

show abstract

“…Patienten mit DM hatten, verglichen mit Patienten mit PM und IBM, das höchste relative Sterberisiko. Todesursachen waren, neben einer bestehenden Krebserkrankung, pulmonale und kardiale Komplikationen der DM . Damit bleibt die Therapie trotz möglicher Steroidgabe eine Herausforderung.…”

Section: Therapieunclassified

Adulte Form der Dermatomyositis ‐ ein Update

Schlecht

Sunderkötter

Niehaus

et al. 2020

J Deutsche Derma Gesell

View full text Add to dashboard Cite

Die adulte Form der Dermatomyositis (DM) wird mit einer Prävalenz von 6-7 auf 100 000 Einwohner pro Jahr angegeben. Auf Grund der nachweislich steigenden Inzidenz, der häufig unterschätzen Systembeteiligung und neuer Entwicklungen zu den Myositis-spezifischen Antikörpern (MSA) wurde diese kompakte Übersicht zur Dermatomyositis erarbeitet. Des Weiteren wird das klinische Spektrum nicht nur dermatologischer Parameter, sondern auch organischer Symptome erläutert. Die diagnostische Aufarbeitung wie auch therapeutische Regime, basierend auf der S2k-Leitlinie und aktueller Literatur, werden präsentiert. Die Dringlichkeit einer frühen Diagnosestellung wird deutlich, zum einen da circa 30 % der DM-Fälle assoziiert Tumoren aufweisen, Verläufe oft mit Lungenfibrose vergesellschaftet sind und die Myositis zu irreversiblen Muskelschäden führt. Die klinischen Zeichen und eine korrekte Interpretation der serologischen Befunde geben wertvolle Hinweise für die Ausprägung der DM, die Indikationsstellung für weitergehende diagnostische Maßnahmen, die Prognose und Therapiewahl.

show abstract

Survival and cancer risk in an unselected and complete Norwegian idiopathic inflammatory myopathy cohort

Abstract: Our results suggest that mortality rates and cancer risk remain elevated in DM, and to a lesser degree also in PM. Mortality rate was also increased in sIBM, but some deaths appeared to be due to potentially preventable causes.

Cited by 83 publications

References 42 publications

Mortality in idiopathic inflammatory myopathy: results from a Swedish nationwide population-based cohort study

Mortality in idiopathic inflammatory myopathy: results from a Swedish nationwide population-based cohort study

Cardiac involvement in adult and juvenile idiopathic inflammatory myopathies

Adulte Form der Dermatomyositis ‐ ein Update

Contact Info

Product

Resources

About