Survival and Failure Outcomes in Primary Thyroid Lymphomas: A Single Centre Experience of Combined Modality Approach

Kumar, Ritesh; Khosla, Divya; Kumar, Narendra; Ghoshal, Sushmita; Bera, Anjan; Das, Ashim; Sharma, Suresh C.

doi:10.1155/2013/269034

Cited by 22 publications

(15 citation statements)

References 29 publications

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“…In 10% of patients, type B symptoms can be seen such as fever, night sweat, and weight loss (21). Symptoms of hypothyroidism can be seen at a rate of 10%; however, most patients are reported to be euthyroid (22).…”

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confidence: 99%

Eleven patients with primary thyroid lymphoma: a single center experience

Bostancı¹,

Dikmen²,

Akyürek³

et al. 2017

Turk J Med Sci

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IntroductionPrimary thyroid lymphoma (PTL) is quite a rare malignancy, constituting 1%-5% of all thyroid malignancies, and 2% of all extranodal lymphomas (1). It is seen more frequently in females with chronic Hashimoto's thyroiditis, with 3-4fold higher incidence than in male patients. PTL incidence peaks in the mid-sixties; hence, half of PTL patients are between the age of 60 and 79 years (2,3).The most frequent complaint is a large palpable swelling in the neck that resembles anaplastic thyroid cancers. Diagnosis must be performed rapidly due to differences in treatment. A large neck mass triggered by PTL also causes symptoms such as dysphagia, dyspnea, and hoarseness due to mass effect, which is typically associated with the disease. In addition to these symptoms, some patients may show B symptoms such as fever, night sweats, and weight loss of 10% and higher in the last 6 months.Histopathologically, PTLs appear in the form of B-cell and T-cell type non-Hodgkin's lymphomas (4). B-cell non-Hodgkin lymphoma, which is the most Background/aim: Primary thyroid lymphoma (PTL) is a very rare thyroid malignancy. It should be diagnosed and treated immediately and accurately. Our aim was to evaluate the diagnostic methods and treatment results for patients with PTL. Materials and methods: We retrospectively evaluated the records of 11 patients with PTL from 2009 to 2015, diagnosed at our institute. Age, sex, stage, histopathologic type, presence of Hashimoto's thyroiditis, diagnostic methods, treatment types, and recurrence were examined.Results: Six patients were female, 5 were male, and the median age of the patients was 61 years (range: 15-76 years). All patients had a large palpable mass in the neck. Fine needle aspirate (FNA) biopsy was performed in all patients; however, it was useful only in the diagnosis of 7 patients. Excisional and surgical biopsy was performed in 4 patients. All patients had non-Hodgkin B-cell lymphoma, including 9 cases of diffuse large B-cell lymphoma (DLBCL), and 2 patients had mucosa-associated lymphoid tissue (MALT) lymphoma. Recurrence was observed in one patient. Median survival was 34 months. Conclusions:The preferred option for the diagnosis of PTL should be FNA biopsy, and the treatment should be decided on according to whether the disease is limited to the thyroid gland or not, its histological type, and its stage.

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confidence: 99%

Eleven patients with primary thyroid lymphoma: a single center experience

Bostancı¹,

Dikmen²,

Akyürek³

et al. 2017

Turk J Med Sci

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“…In localized tumors, it is usually favorable with a survival rate at 5 years from 70% to 80%. 10 However, the prognosis is very poor for lesions with extracapsular invasion (IIE) (20 to 50%). For stages IIIE and IV, the rates are 15 to 35%.…”

Section: Discussionmentioning

confidence: 99%

Rare Localization of Lymphoma

Marrakchi¹,

Zhani²,

Chahed³

et al. 2016

Otolaryngol Open J

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Objective: Primitive Thyroid Lymphomas (PTL) are rare tumors. Women in the sixth or seventh decade of life are more commonly affected. In the present study, we report a case of primitive thyroid lymphoma and we review the epidemiology, the clinical presentation, the diagnosis, and the treatment of this rare disorder. Case Report: A 47-year-old woman presented to our department reporting a recent-onset neck mass since 3 months. Clinical examination revealed an enlargement of the thyroid gland with a 2.5 cm-firm left nodule. Cervical ultrasound was done. The patient had a thyroidectomy associated with bilateral Central Lymph Node Dissection (CLND). The diagnosis was a transformation of a Mucosa-associated lymphoid tissue (MALT) lymphoma into an aggressive Diffuse Large B-Cell Lymphoma (DLBCL). Conclusion: The most common type of primary thyroid lymphoma (PTL) is diffuse large B-cell lymphoma, which behaves in a more aggressive manner than mucosa-associated lymphoid tissue lymphoma. Treatment and prognosis of PTL depend upon the histology and stage of the tumor at diagnosis.

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“…Adenopathy can be associated with the primary complaints as well [40]. Complaints of dysphagia, dyspnea, and hoarseness are uncommon, and signify advanced disease with compressive symptoms or invasion of the recurrent laryngeal nerve [2].…”

Section: Primary Thyroid Lymphomamentioning

confidence: 99%