Survival and malformations rates, oxidative status in early life stages of Cyprinus carpio due to exposure to environmentally realistic concentrations of paracetamol

Gutiérrez-Noya, Verónica Margarita; Gómez-Oliván, Leobardo Manuel; Ramírez-Montero, María del Carmen; Islas-Flores, Hariz; Galár-Martínez, Marcela; García-Medina, Sandra

doi:10.1016/j.scitotenv.2020.144585

Cited by 10 publications

(1 citation statement)

References 92 publications

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“…nephrotoxicity in the catfish Rhamdia quelen Quoy & Gaimard, 1824 (Perussolo et al, 2019) and alterations in embryonic development in the fish Cyprinus carpio Linnaeus, 1758 (Gutiérrez-Noya et al, 2021). Besides these effects, there is a concern related to its potential action as an endocrine disruptor (Ebele et al, 2017).…”

Section: Graphical Abstractmentioning

confidence: 99%

A multibiomarker approach to investigate paracetamol effects in the reproduction regulatory axis of a male Neotropical catfish Rhamdia quelen

Perussolo,

Vicentini,

Lyra

et al. 2023

Acta Limnol. Bras.

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Aim Paracetamol (PCM), or acetaminophen, is one of the most used drugs for human treatment of pain and fever. Since it has often been found in the aquatic environment, the aim of this study was to investigate the effects of PCM on the reproductive axis of male Rhamdia quelen catfish. Methods Different biomarkers were evaluated in hypothalamus, liver and gonads, as well as the plasma sexual hormone quantification. The fish were exposed to three PCM concentrations: 0.25, 2.5 and 25 µg.L-1 and to a control group (solvent acetone 0.0003%). After 14 days of exposure, fish were anesthetized, for blood sampling and biometrics, and after euthanasia, the tissues were sampled. Plasma was used for 11- keto testosterone and 17β - estradiol quantification. The hypothalamus was collected for brain aromatase (cyp19a1b) gene expression; the liver for the vitellogenin (vtg) gene expression and biochemical biomarkers; and gonad for the biochemical and histological biomarkers analyses. Results No alterations were observed in the hormone’s levels, sexual maturation level or in cyp19a1b and vtg gene expression. In the liver the non-protein thiols concentration increased at 2.5 µg.L-1 of PCM, and the superoxide dismutase (SOD) activity was reduced at 0.25 µg.L-1 of PCM. In gonads, glutathione S-transferase (GST) activity decreased and SOD activity increased at 25 µg.L-1 of PCM, while the glutathione peroxidase (GPx) activity reduced after exposure to both PCM concentrations. Conclusion The results showed that environmental concentrations of PCM can cause alterations in the antioxidant system, mainly in the gonads of R. quelen males. However, without significant change in the hormones levels or in the expression of genes related to the reproduction axis. These alterations occurred at concentrations already found in aquatic environment, including in Brazil.

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Section: Graphical Abstractmentioning

confidence: 99%

A multibiomarker approach to investigate paracetamol effects in the reproduction regulatory axis of a male Neotropical catfish Rhamdia quelen

Perussolo,

Vicentini,

Lyra

et al. 2023

Acta Limnol. Bras.

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Occurrence and Environmental Risk Assessment of Contaminants of Emerging Concern in Brazilian Surface Waters

Oliveira,

Mansano,

Holanda

et al. 2024

Enviro Toxic and Chemistry

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We investigated the occurrence and the environmental risk of eight contaminants of emerging concern (CECs; acetaminophen, naproxen, diclofenac, methylparaben, 17β‐estradiol, sulfathiazole, sulfadimethoxine, and sulfamethazine) in three Brazilian water bodies, namely, the Monjolinho River Basin (São Paulo State), the Mogi Guaçu River (São Paulo State), and the Itapecuru River (Maranhão State) in three sampling campaigns. The CECs were only quantified in surface water samples collected at the Monjolinho River Basin. Acetaminophen, naproxen, and methylparaben were detected in the range of <200 to 575.9 ng L−1, <200 to 224.7 ng L−1, and <200 to 303.6 ng L−1, respectively. The detection frequencies of the three measured compounds were between 33% and 67%. The highest concentrations of CECs were associated with intense urbanization and untreated sewage discharge. Furthermore, CEC concentrations were significantly correlated with total organic carbon, electrical conductivity, and dissolved oxygen levels, suggesting that domestic pollution from urban areas is an important source in the distribution of CECs in the Monjolinho River Basin. The environmental risk assessment indicated a high risk for acetaminophen (risk quotient [RQ] values between 2.1 and 5.8), a medium risk for naproxen (RQs between 0.6 and 0.7), and a low risk for methylparaben (RQs < 0.1) to the freshwater biota of the Monjolinho River Basin. Our findings show potential threats of CECs in Brazilian water bodies, especially in vulnerable areas, and reinforce the need for improvements in environmental regulations to include monitoring and control of these compounds in aquatic systems. Environ Toxicol Chem 2024;00:1–12. © 2024 SETAC

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Paracetamol environmental remediation and ecotoxicology: a review

Vieira,

Spode,

Dotto

et al. 2024

Environ Chem Lett

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Survival and malformations rates, oxidative status in early life stages of Cyprinus carpio due to exposure to environmentally realistic concentrations of paracetamol

Cited by 10 publications

References 92 publications

A multibiomarker approach to investigate paracetamol effects in the reproduction regulatory axis of a male Neotropical catfish Rhamdia quelen

A multibiomarker approach to investigate paracetamol effects in the reproduction regulatory axis of a male Neotropical catfish Rhamdia quelen

Occurrence and Environmental Risk Assessment of Contaminants of Emerging Concern in Brazilian Surface Waters

Paracetamol environmental remediation and ecotoxicology: a review

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