Survival and Migration of Rat Olfactory Ensheathing Cells after Transplantation into Posttraumatic Cysts in the Spinal Cord

Воронова, А Д; Valikhov, Marat P.; Степанова, О. В.; Melnikov, Pavel; Чадин, А. В.; Sidoruk, K N; Semkina, Alevtina S.; Abakumov, Maxim; Reshetov, Igor V.; Chekhonin, V. P.

doi:10.1007/s10517-018-4299-z

Cited by 4 publications

(2 citation statements)

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“…Spinal cord injury is a common site in the central nervous system, and can lead to sensory and motor dysfunction after ( Muniswami and Tharion, 2018 ; Voronova et al, 2018 ). OECs transplantation can promote axonal regeneration and myelination in spinal cord injury, and can restore part of sensory and motor functions, which all lie in the biological function of OECs ( Reshamwala et al, 2019 ) ( Figure 1 ).…”

Section: The Role Of Oecs In Treatment Of Nerve Injurymentioning

confidence: 99%

Olfactory ensheathing cells and neuropathic pain

Liu

Wang

et al. 2023

Front. Cell Dev. Biol.

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Damage to the nervous system can lead to functional impairment, including sensory and motor functions. Importantly, neuropathic pain (NPP) can be induced after nerve injury, which seriously affects the quality of life of patients. Therefore, the repair of nerve damage and the treatment of pain are particularly important. However, the current treatment of NPP is very weak, which promotes researchers to find new methods and directions for treatment. Recently, cell transplantation technology has received great attention and has become a hot spot for the treatment of nerve injury and pain. Olfactory ensheathing cells (OECs) are a kind of glial cells with the characteristics of lifelong survival in the nervous system and continuous division and renewal. They also secrete a variety of neurotrophic factors, bridge the fibers at both ends of the injured nerve, change the local injury microenvironment, and promote axon regeneration and other biological functions. Different studies have revealed that the transplantation of OECs can repair damaged nerves and exert analgesic effect. Some progress has been made in the effect of OECs transplantation in inhibiting NPP. Therefore, in this paper, we provided a comprehensive overview of the biology of OECs, described the possible pathogenesis of NPP. Moreover, we discussed on the therapeutic effect of OECs transplantation on central nervous system injury and NPP, and prospected some possible problems of OECs transplantation as pain treatment. To provide some valuable information for the treatment of pain by OECs transplantation in the future.

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Section: The Role Of Oecs In Treatment Of Nerve Injurymentioning

confidence: 99%

Olfactory ensheathing cells and neuropathic pain

Liu

Wang

et al. 2023

Front. Cell Dev. Biol.

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“…The treatment period in these 40 studies is considered as acute phase in this review. A further 13 studies reported a waiting period of 1 week, 6 studies reported 2 weeks' delay before treatment, 3 studies reported 4 weeks, 35,45,85 and 2 more studies reported 8 weeks 45,85 of waiting period before treatment. Out of these, two studies compared treatments at the same day as injury (zero days) and 1 week 49,51 .…”

Section: Time Between Injury and Transplantation Is Important For Oec Survivalmentioning

confidence: 99%

Survival and Integration of Transplanted Olfactory Ensheathing Cells are Crucial for Spinal Cord Injury Repair: Insights from the Last 10 Years of Animal Model Studies

2019

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Olfactory ensheathing cells (OECs), the glial cells of the primary olfactory nervous system, support the natural regeneration of the olfactory nerve that occurs throughout life. OECs thus exhibit unique properties supporting neuronal survival and growth. Transplantation of OECs is emerging as a promising treatment for spinal cord injury; however, outcomes in both animals and humans are variable and the method needs improvement and standardization. A major reason for the discrepancy in functional outcomes is the variability in survival and integration of the transplanted cells, key factors for successful spinal cord regeneration. Here, we review the outcomes of OEC transplantation in rodent models over the last 10 years, with a focus on survival and integration of the transplanted cells. We identify the key factors influencing OEC survival: injury type, source of transplanted cells, co-transplantation with other cell types, number and concentration of cells, method of delivery, and time of transplantation after the injury. We found that two key issues are hampering optimization and standardization of OEC transplantation: lack of (1) reliable methods for identifying transplanted cells, and (2) three-dimensional systems for OEC delivery. To develop OEC transplantation as a successful and standardized therapy for spinal cord injury, we must address these issues and increase our understanding of the complex parameters influencing OEC survival.

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