Survival and Morbidity of Preterm Children Born at 22 Through 34 Weeks’ Gestation in France in 2011

Ancel, Pierre‐Yves; Goffinet, François; Kuhn, Pierre; Langer, B.; Matis, Jacqueline; Hernandoréna, X.; Chabanier, P; Joly-Pedespan, Laurence; Lecomte, Bénédicte; Vendittelli, Françoise; Dreyfus, Michel; Guillois, B.; Burguet, A.; Sagot, P; Sizun, Jacques; Beuchée, Alain; Rouget, Florence; Favreau, Amélie; Saliba, Élie; Bednarek, Nathalie; Morville, P; Thiriez, Gérard; Marpeau, L.; Marret, Stéphane; Kayem, Gilles; Durrmeyer, Xavier; Granier, Michèle; Baud, Olivier; Jarreau, Pierre‐Henri; Mitanchez, Delphine; Boileau, Pascal; Boulot, P.; Cambonie, Gilles; Daudé, Hubert; Bédu, A.; Mons, F.; Fresson, Jeanne; Vieux, Rachel; Alberge, C.; Arnaud, Catherine; Vayssière, Christophe; Truffert, Patrick; Pierrat, Véronique; Subtil, D.; D’ercole, C.; Gire, Catherine; Siméoni, Umberto; Bongain, A.; Sentilhes, Loïc; Rozé, Jean‐Christophe; Gondry, J.; Léké, A.; Deiber, Michel; Claris, Olivier; Picaud, Jean‐Charles; Ego, Anne; Debillon, Thierry; Poulichet, A; Coliné, E; Favre, A.; Fléchelles, Olivier; Sampériz, Sylvain; Ramful, Duksha; Branger, B.; Benhammou, Valérie; Foix‐L’Hélias, L.; Marchand-Martin, Laetitia; Kaminski, Monique

doi:10.1001/jamapediatrics.2014.3351

Cited by 638 publications

(492 citation statements)

References 28 publications

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“…We found that frequencies of prematurity (21%) and SGA (24%) were high in patients with NS compared with the general population in France (7 and 5% respectively) (18). Patients with NS were significantly shorter at birth compared with healthy neonates, but had normal birth weight and head circumference, indicating an asymetrical SGA.…”

Section: Discussionmentioning

confidence: 73%

Growth patterns of patients with Noonan syndrome: correlation with age and genotype

Cessans

Ehlinger

Arnaud

et al. 2016

European Journal of Endocrinology

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Background: Growth patterns of patients with Noonan syndrome (NS) were established before the involved genes were identified. Objective: The goal of this study was to compare growth parameters according to genotype in patients with NS. Subjects and methods: The study population included 420 patients (176 females and 244 males) harboring mutations in the PTPN11, SOS1, RAF1, or KRAS genes. NS-associated PTPN11 mutations (NS-PTPN11) and NS with multiple lentiginesassociated PTPN11 mutations (NSML-PTPN11) were distinguished. Birth measures and height and body mass index (BMI) measures at 2, 5, 10 years, and adulthood were compared with the general population and between genotypes. Results: Patients with NS were shorter at birth (mean birth length standard deviation score (SDS): -1.0 ± 1.4; P < 0.001) and throughout childhood than the healthy population, with height SDS being -2.1 ± 1.3 at 2 years, and -2.1 ± 1.2 at 5 and 10 years and adulthood (P < 0.001). At birth, patients with NS-PTPN11 were significantly shorter and thinner than patients with NSML-PTPN11, SOS1, or KRAS. Growth retardation was significantly less severe and less frequent at 2 years in patients with NSML-PTPN11 and SOS1 than in patients with NS-PTPN11 (P < 0.001 and P = 0.002 respectively). Patients with NS had lower BMI at 10 years (P < 0.001). No difference between genotypes was demonstrated. Conclusion: Determining the growth patterns of patients with NS according to genotype should better inform clinicians about the natural course of growth in NS so that they can optimize the follow-up and management of these patients.

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Section: Discussionmentioning

confidence: 73%

Growth patterns of patients with Noonan syndrome: correlation with age and genotype

Cessans

Ehlinger

Arnaud

et al. 2016

European Journal of Endocrinology

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“…In contrast, SGA, AGA, LGA, and Z score for BW all report measures standardized for GA and sex, and as such are often used as surrogate markers for fetal growth. Increased mortality in LBW infants with CHD does not address the question of whether fetal growth—as measured by SGA/AGA/LGA or Z score for BW—impacts this outcome since the increased mortality rate in LBW infants is mainly driven by lower GA, and it is well known that GA is a major determinant of mortality in infants with7, 8, 25 and without CHD 26…”

Section: Discussionmentioning

confidence: 99%

Effect of Fetal Growth on 1‐Year Mortality in Neonates With Critical Congenital Heart Disease

Steurer

Baer

Burke

et al. 2018

JAHA

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BackgroundInfants with critical congenital heart disease (CCHD) are more likely to be small for gestational age (GA). It is unclear how this affects mortality. The authors investigated the effect of birth weight Z score on 1‐year mortality separately in preterm (GA <37 weeks), early‐term (GA 37–38 weeks), and full‐term (GA 39–42 weeks) infants with CCHD.Methods and ResultsLive‐born infants with CCHD and GA 22 to 42 weeks born in California 2007–2012 were included in the analysis. The primary predictor was Z score for birth weight and the primary outcome was 1‐year mortality. Multivariable logistic regression was used. Results are presented as adjusted odds ratios and 95% confidence intervals (CIs). The authors identified 6903 infants with CCHD. For preterm and full‐term infants, only a Z score for birth weight <−2 was associated with increased mortality compared with the reference group (Z score 0–0.5, adjusted odds ratio, 2.15 [95% CI, 1.1–4.21] and adjusted odds ratio, 3.93 [95% CI, 2.32–6.68], respectively). In contrast, in early‐term infants, the adjusted odds ratios for Z scores <−2, −2 to −1, and −1 to −0.5 were 3.42 (95% CI, 1.93–6.04), 1.78 (95% CI, 1.12–2.83), and 2.03 (95% CI, 1.27–3.23), respectively, versus the reference group.Conclusions GA seems to modify the effect of birth weight Z score on mortality in infants with CCHD. In preterm and full‐term infants, only the most severe small‐for‐GA infants (Z score <−2) were at increased risk for mortality, while, in early‐term infants, the risk extended to mild to moderate small‐for‐GA infants (Z score <−0.5). This information helps to identify high‐risk infants and is useful for surgical planning.

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“…Paediatric follow-up visits with these children are in place to manage and diagnose or eventually treat some complications, especially neurological impairments. Other studies have shown that the majority of new-borns who make it through the early neonatal critical period will survive without major lesions or defects or with only moderate difficulties [15,19,20].…”

Section: Limitations Of the Studymentioning

confidence: 99%

Short-term Survival and Morbidity of Extremely premature Infants Born between 20 Weeks and 24 Weeks+6 Days Gestation

Alouini¹,

Solange²,

Ramos³

et al. 2017

J Preg Child Health

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Objective: To evaluate the morbidity and mortality of extremely premature infants (EPIs) born between 20 weeks and 24 weeks+6 days gestation at hospital discharge. Methods:This was a retrospective study that included all extremely preterm births between 2006 and 2012 at a tertiary maternity care centre with a neonatal intensive care unit.Results: Seventy-eight EPIs were born during the study period out of 30,000 deliveries (0.26%). Thirty-nine EPIs (50%) survived and had a mean length of hospital stay of 43 days. The mean weight of EPIs was 723 ± 179 g. The rate of survival of EPIs increases with gestational age. Forty-nine EPIs (62%) exhibited neonatal respiratory distress (NNRD), which evolved into a bronchopulmonary dysplasia in 28 cases (35%); 33 EPIs (42%) had a maternofetal infection, while 20 (26%) experienced ventricular hemorrhage. Ten EPI (13%) displayed enterocolitis and 17 (22%) had retinopathy. No EPIs born before 22 weeks gestation survived Twenty-four EPIs left the hospital with their mothers after being scheduled for a routine paediatric follow-up visit and 15 were transferred to another hospital: 10 for surgical treatment of patent ductus arteriosus and 5 to be closer to their mothers. Conclusion:The survival rates of EPIs between 20 and 24 weeks of gestation are high. NNRD, infections, and neurological and retinal complications were the main causes of morbidity. The results of this active management study of extremely preterm births were satisfactory at the short follow-up visits. Antenatal corticosteroids and magnesium sulfate administration should be discussed beginning at 22 weeks of gestation.

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Survival and Morbidity of Preterm Children Born at 22 Through 34 Weeks’ Gestation in France in 2011

Cited by 638 publications

References 28 publications

Growth patterns of patients with Noonan syndrome: correlation with age and genotype

Growth patterns of patients with Noonan syndrome: correlation with age and genotype

Effect of Fetal Growth on 1‐Year Mortality in Neonates With Critical Congenital Heart Disease

Short-term Survival and Morbidity of Extremely premature Infants Born between 20 Weeks and 24 Weeks+6 Days Gestation

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