Survival and patterns of recurrence in 200 oral cancer patients treated by radical surgery and neck dissection

Woolgar, Julia A.; Rogers, Simon N.; West, Christopher R.; Errington, R.D.; Brown, Jeremy; Vaughan, E.D.

doi:10.1016/s1368-8375(98)00113-4

Cited by 235 publications

(148 citation statements)

References 23 publications

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“…The reported risk of local failure in the presence of close margins in patients with oral SCC has been variously reported between 8.6% and 80% [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] (Table 4). We continue to lack a standardized treatment protocol with regard to close margins.…”

Section: Discussionmentioning

confidence: 99%

Close margin alone does not warrant postoperative adjuvant radiotherapy in oral squamous cell carcinoma

Ch’ng

Corbett-Burns

Stanton

et al. 2013

Cancer

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BACKGROUND: There are major variations between institutions regarding postoperative adjuvant therapy for adverse features in patients with oral squamous cell carcinoma (SCC). The authors' practice has been to not recommend any adjuvant therapy on the basis of close (<5 mm but uninvolved) margins unless there are additional adverse features. The primary objective of this study was to assess whether the local control achieved in this patient cohort was acceptable. METHODS: In this single-institution, retrospective analysis, local control was the primary endpoint, and disease-specific survival (DSS) was the secondary endpoint. Differences in survival were determined using the log-rank test, and survival curves were generated using the Kaplan-Meier method. RESULTS: One hundred forty-four patients (79 men and 65 women; median age, 64.1 years; mean follow-up, 3.3 years) underwent surgery alone for oral SCC with curative intent and were recorded as having close tumor margins on histology. The local control rate for all patients who underwent surgery alone was 91% (95% confidence interval, 81.9%-95.2%), and the DSS rate was 84% (95% confidence interval, 74.0%-89.9%) at 5 years. There was no pattern of worse local control or DSS rates with the ordered stratification of close margins. The 5-year local control rates for having 0, 1, 2, and 3 additional adverse features were 100%, 96%, 83%, and 71%, respectively (P 5.004; trend test). CONCLUSIONS: Surgery alone without postoperative adjuvant therapy offered acceptable local control in patients who had close margin status as their only adverse feature and may be reasonable in the presence of 1 other adverse clinicopathologic feature.

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Section: Discussionmentioning

confidence: 99%

Close margin alone does not warrant postoperative adjuvant radiotherapy in oral squamous cell carcinoma

Ch’ng

Corbett-Burns

Stanton

et al. 2013

Cancer

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“…In addition, the survival and prognostic factors of different anatomical sites are reported to differ. The 5-year survival rates fall between 40 to 60%, based on the site (Woolgar et al, 1999;Pericot et al, 2000). These rates are likely the result of multiple factors, including the stage of disease at the time of diagnosis, treatment modalities, and the site-specific morbidity associated with each treatment.…”

Section: Introductionmentioning

confidence: 99%

Survival and Prognostic Factors of Different Sites of Head and Neck Cancer: An Analysis from Thailand

Pruegsanusak¹,

Peeravut²,

Leelamanit³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…In Australia an overall survival rate of 83.3% has been reported (Chandu, 2005). In United Kingdom the 5-year overall survival was 64% (Woolgar et al, 1999). In India a survival rate of 30.5% has been reported (Yeole et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Survival Following Non Surgical Treatments for Oral Cancer: a Single Institutional Result

Larizadeh

Shabani²

2012

Asian Pacific Journal of Cancer Prevention

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Survival and patterns of recurrence in 200 oral cancer patients treated by radical surgery and neck dissection

Cited by 235 publications

References 23 publications

Close margin alone does not warrant postoperative adjuvant radiotherapy in oral squamous cell carcinoma

Close margin alone does not warrant postoperative adjuvant radiotherapy in oral squamous cell carcinoma

Survival and Prognostic Factors of Different Sites of Head and Neck Cancer: An Analysis from Thailand

Survival Following Non Surgical Treatments for Oral Cancer: a Single Institutional Result

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