Survival and Potential Years of Life Lost After Hip Fracture in Men and Age-matched Women

Trombetti, Andrea; Herrmann, Françoís; Hoffmeyer, Pierre; Schürch, Marc-André; Bonjour, Jean‐Philippe; Rizzoli, René

doi:10.1007/s001980200100

Cited by 189 publications

(110 citation statements)

References 33 publications

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“…In particular, studies that rely on comparisons between mortality in hip fracture patients relative to age-and sex-specific expected mortality in the general population (13,32,33) may not have adequately accounted for the pre-fracture frailty and illness in those who sustain a hip fracture relative to their peers. As a result, these studies may suggest a much greater adverse health impact associated with fracture than is warranted.…”

Section: Discussionmentioning

confidence: 99%

Excess mortality following hip fracture: the role of underlying health status

et al. 2007

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Section: Discussionmentioning

confidence: 99%

Excess mortality following hip fracture: the role of underlying health status

et al. 2007

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“…Although vertebral fractures that come to clinical attention are less costly than hip fractures, the morbidity from an acute fracture in the first year is nearly as severe as that due to a hip fracture [64] and is associated with an increase in mortality [65]. Vertebral fractures are also a very strong risk factor for a further fracture at the spine and elsewhere [34][35][36]66]. margin and is associated with dorsal angulation and displacement of the distal fragment of the radius.…”

Section: Vertebral Fracturementioning

confidence: 99%

“…There is a high incidence of algodystrophy-a syndrome which gives rise to pain, tenderness, stiffness and swelling of the hand, and more rarely to frozen shoulder syndrome [69]. Moreover, the risk of other osteoporotic fractures in later life is also increased after Colles' fracture [34,35,66]. …”

Section: Vertebral Fracturementioning

confidence: 99%

“…However, alendronate, etidronate, risedronate zoledronic acid and teriparatide are also approved for the prevention and treatment of glucocorticoid-induced osteoporosis in Europe [52] and alendronate, risedronate, zoledronic acid, strontium ranelate and teriparatide are approved for the treatment of osteoporosis in men. [38,[62][63][64][65][66][67][68][69][70][71][72] (Table 10). Because of this broader spectrum of anti-fracture efficacy these agents are generally regarded as preferred options in the prevention of fractures in postmenopausal women.…”

Section: Major Pharmacological Interventionsmentioning

confidence: 99%

“…Although the mortality after a fracture has been reported to be higher for men compared to women [62], the mortality hazard in the general population is higher in men than in women. Thus, the difference in mortality between men and women is less marked when relating the mortality to that of the general population of the same sex [63][64][65][66]. Several studies have shown that mortality is highest in the immediate fracture period and then decreases with time.…”

Section: Mortality Due To Fracturementioning

confidence: 99%

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Osteoporosis in the European Union: medical management, epidemiology and economic burden

Hernlund¹,

Svedbom²,

Ivergård³

et al. 2013

Arch Osteoporos

2,133

1,048

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Summary This report describes the epidemiology, burden, and treatment of osteoporosis in the 27 countries of the European Union (EU27). Introduction Osteoporosis is characterized by reduced bone mass and disruption of bone architecture, resulting in increased risk of fragility fractures which represent the main clinical consequence of the disease. Fragility fractures are associated with substantial pain and suffering, disability and even death for affected patients and substantial costs to society. The aim of this report was to characterize the burden of osteoporosis in the EU27 in 2010 and beyond. Methods The literature on fracture incidence and costs of fractures in the EU27 was reviewed and incorporated into a model estimating the clinical and economic burden of osteoporotic fractures in 2010.Results Twenty-two million women and 5.5 million men were estimated to have osteoporosis; and 3.5 million new fragility fractures were sustained, comprising 610,000 hip fractures, 520,000 vertebral fractures, 560,000 forearm fractures and 1,800,000 other fractures (i.e. fractures of the pelvis, rib, humerus, tibia, fibula, clavicle, scapula, sternum and other femoral fractures). The economic burden of incident and prior fragility fractures was estimated at € 37 billion. Incident fractures represented 66 % of this cost, long-term fracture care 29 % and pharmacological prevention 5 %. Previous and incident fractures also accounted for 1,180,000 quality-adjusted life years lost during 2010. The costs are expected to increase by 25 % in 2025. The majority of individuals who have sustained an osteoporosis-related fracture or who are at high risk of fracture are untreated and the number of patients on treatment is declining.

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Mortality Risk Associated With Low-Trauma Osteoporotic Fracture and Subsequent Fracture in Men and Women

Bliuc

Nguyen²,

Milch³

et al. 2009

JAMA

1,446

872

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Context There are few data on long-term mortality following osteoporotic fracture and fewer following subsequent fracture.Objectives To examine long-term mortality risk in women and men following all osteoporotic fractures and to assess the association of subsequent fracture with that risk. Design, Setting, and ParticipantsProspective cohort from the Dubbo Osteoporosis Epidemiology Study of community-dwelling women and men aged 60 years and older from Dubbo, Australia, who sustained a fracture between April 1989 and May 2007.Main Outcome Measures Age-and sex-specific standardized mortality ratios (SMRs) compared with the overall Dubbo population for hip, vertebral, major, and minor fractures. ResultsIn women, there were 952 low-trauma fractures followed by 461 deaths, and in men, 343 fractures were followed by 197 deaths. Age-adjusted SMRs were increased following hip fractures (SMRs, 2.43 [95% confidence interval [CI], 2.02-2.93] and 3.51 [95% CI, 2.65-4.66]), vertebral fractures (SMRs, 1.82 [95% CI, 1.52-2.17] and 2.12 [95% CI, 1.66-2.72]), major fractures (SMRs, 1.65 [95% CI, 1.31-2.08] and 1.70 [95% CI, 1.23-2.36]), and minor fractures (SMRs, 1.42 [95% CI, 1.19-1.70] and 1.33 [95% CI, 0.99-1.80]) for both women and men, respectively.Mortality was increased for all ages for all fractures except minor fractures for which increased mortality was only apparent for those older than 75 years. Increased mortality risk persisted for 5 years for all fractures and up to 10 years for hip fractures. Increases in absolute mortality that were above expected, for 5 years after fracture, ranged from 1.3 to 13.2 per 100 person-years in women and from 2.7 to 22.3 per 100 person-years in men, depending on fracture type. Subsequent fracture was associated with an increased mortality hazard ratio of 1.91 (95% CI, 1.54-2.37) in women and 2.99 (95% CI, 2.11-4.24) in men. Mortality risk following a subsequent fracture then declined but beyond 5 years still remained higher than in the general population (SMR, 1.41 [95% CI, 1.01-1.97] and SMR, 1.78 [95% CI, 0.96-3.31] for women and men, respectively). Predictors of mortality after any fragility fracture for both men and women included age, quadriceps weakness, and subsequent fracture but not comorbidities. Low bone mineral density, having smoked, and sway were also predictors for women and less physical activity for men. ConclusionsIn a sample of older women and men, all low-trauma fractures were associated with increased mortality risk for 5 to 10 years. Subsequent fracture was associated with increased mortality risk for an additional 5 years.

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Survival and Potential Years of Life Lost After Hip Fracture in Men and Age-matched Women

Cited by 189 publications

References 33 publications

Excess mortality following hip fracture: the role of underlying health status

Excess mortality following hip fracture: the role of underlying health status

Osteoporosis in the European Union: medical management, epidemiology and economic burden

Mortality Risk Associated With Low-Trauma Osteoporotic Fracture and Subsequent Fracture in Men and Women

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