2019
DOI: 10.1007/s11060-019-03171-6
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Survival and prognostic factors in surgically treated brain metastases

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Cited by 38 publications
(36 citation statements)
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References 45 publications
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“…As in the present series, diagnosis of multiple BM represents a predictive value for poor survival in various studies ( 11 13 ). Surgical resection only removes a part of the intracranial tumor burden, and the target area for postoperative radio/chemotherapy is larger, especially for radiosurgery, which in turn might be associated with an increased postinterventional risk ( 14 ).…”
Section: Discussionsupporting
confidence: 62%
See 1 more Smart Citation
“…As in the present series, diagnosis of multiple BM represents a predictive value for poor survival in various studies ( 11 13 ). Surgical resection only removes a part of the intracranial tumor burden, and the target area for postoperative radio/chemotherapy is larger, especially for radiosurgery, which in turn might be associated with an increased postinterventional risk ( 14 ).…”
Section: Discussionsupporting
confidence: 62%
“…In an elderly patient population with brain metastasis requiring surgery, this study identifies the presence of multiple BM, infratentorial location of BM, preoperatively elevated CRP levels, and frail condition of the patient as independent predictors of worse overall survival. As in the present series, diagnosis of multiple BM represents a predictive value for poor survival in various studies (11)(12)(13). Surgical resection only removes a part of the intracranial tumor burden, and the target area for postoperative radio/chemotherapy is larger, especially for radiosurgery, which in turn might be associated with an increased postinterventional risk (14).…”
Section: Discussionmentioning
confidence: 59%
“…We found that the median survival of patients with BM from sarcomas surgically treated was comparable to that from carcinomas [63]. Additionally, postoperative KPS was improved in 50% (11/22) of the patients and postoperative mortality was 0%.…”
Section: Discussionmentioning
confidence: 67%
“…Our results show that almost half (47.1%) of the patients treated with any combination of BRAF/MEK targeted therapy and immunotherapy develop intracranial disease in the setting of stable or improving extracranial disease, with only 52.9% having progressing extracranial disease at the time of clinical presentation. There is a difference in terms of survival in patients who have intracranial metastatic melanoma and lower functional status due to symptomatic disease compared to those with incidentally found disease [29]. In addition, the Graded Prognostic Assessment score for intracranial melanoma is lower, indicating lower median survival, for patients who are more severely symptomatic as evidenced by a lower Karnofsky Performance Scale [30].…”
Section: Discussionmentioning
confidence: 99%