Survival Benefit of Solid-Organ Transplantation: 10-Year Update

Ferreira, Liam D.; Goff, Cameron; Kamepalli, Spoorthi; Montgomery, Ashley; Miggins, John James; Goss, John A.; Rana, Abbas

doi:10.1007/s10620-023-08012-1

Cited by 6 publications

(3 citation statements)

References 36 publications

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“…In this study, CiteSpace 6.1. R3, VOSviewer 1.6.18, and Microsoft Excel 2019 were used for the bibliometric analysis, visualization methods, and integration analysis ( 5 , 16 ). VOSviewer can extract key information from a wide range of publications, including lead authors, and analyze country and institution, keywords, scientific partnerships, citations, and co-citations ( 17 ).…”

Section: Methodsmentioning

confidence: 99%

“…Kidney transplantation has become the preferred procedure for the treatment of patients with kidney failure because it is the most effective treatment, both medically and economically (1)(2)(3). Advances in immunosuppressive drugs and protocols have markedly reduced the incidence of graft rejection and improved survival rates of patients in recent years (3)(4)(5). Nonetheless, improving long-term transplant outcomes remains a crucial challenge (4).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between the microenvironment and survival in kidney transplantation: a bibliometric analysis from 2013 to 2023

Huang,

Fu,

Feng

et al. 2024

Front. Immunol.

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BackgroundKidney transplantation is considered the most effective treatment for end-stage renal failure. Recent studies have shown that the significance of the immune microenvironment after kidney transplantation in determining prognosis of patients. Therefore, this study aimed to conduct a bibliometric analysis to provide an overview of the knowledge structure and research trends regarding the immune microenvironment and survival in kidney transplantation.MethodsOur search included relevant publications from 2013 to 2023 retrieved from the Web of Science core repository and finally included 865 articles. To perform the bibliometric analysis, we utilized tools such as VOSviewer, CiteSpace, and the R package “bibliometrix”. The analysis focused on various aspects, including country, author, year, topic, reference, and keyword clustering.ResultsBased on the inclusion criteria, a total of 865 articles were found, with a trend of steady increase. China and the United States were the countries with the most publications. Nanjing Medical University was the most productive institution. High-frequency keywords were clustered into 6 areas, including kidney transplantation, transforming growth factor β, macrophage, antibody-mediated rejection, necrosis factor alpha, and dysfunction. Antibody mediated rejection (2019-2023) was the main area of research in recent years.ConclusionThis groundbreaking bibliometric study comprehensively summarizes the research trends and advances related to the immune microenvironment and survival after kidney transplantation. It identifies recent frontiers of research and highlights promising directions for future studies, potentially offering fresh perspectives to scholars in the field.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relationship between the microenvironment and survival in kidney transplantation: a bibliometric analysis from 2013 to 2023

Huang,

Fu,

Feng

et al. 2024

Front. Immunol.

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“…Despite excellent long-term median transplant survival rates-more than 14 years for both kidney and liver [3]-solid organ transplantation comes at a price mostly driven by Viruses 2024, 16, 1 2 of 11 the need for long-term immunosuppression. Complications thereof include predisposition to infections, malignancies, and cardiovascular diseases [4].…”

Section: Introductionmentioning

confidence: 99%

B and T Cell Responses to SARS-CoV-2 Vaccination in Kidney and Liver Transplant Recipients with and without Previous COVID-19

Watschinger,

Stampfel,

Zollner

et al. 2023

Viruses

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(1) Background: Vulnerable populations including transplant recipients are jeopardised by COVID-19. Herein, we report on B and T cell responses among liver and kidney organ recipients at our centre. (2) Methods: 23 liver and 45 kidney (14 thereof combined kidney/pancreas) transplanted patients were vaccinated with two doses of BNT162b2 followed by a booster dose of mRNA-1273 in 28 non-responders 4 months thereafter. Anti-SARS-CoV-2-Ig was measured by specific ELISA and virus neutralisation assay; T cell responses were measured by a spike protein-specific IFN-γ release assay. (3) Results: Compared to controls, B and T cell responses were weak in transplant recipients, particularly in those without prior exposure to SARS-CoV-2. Within this group, only 15% after the first and 58.3% after the second vaccination achieved seroconversion. A total of 14 out of 28 vaccination non-responders achieved a seroconversion after a third dose. Vaccination side effects were more frequent in healthy controls. The use of mycophenolate was associated with reduced anti-SARS-CoV-2-Ig production. (4) Conclusions: Our data confirm that vaccination responses are insufficient after standard vaccination in liver and kidney transplant recipients and are affected to a variable degree by specific immunosuppressants, particularly mycophenolate. Monitoring vaccination success and re-vaccinating those who are unresponsive seems prudent to achieve sufficient titres. Overall, prospective large-scale, multinational, multicentre studies or high-quality meta-analyses will be needed to generate personalised vaccination strategies in order to achieve protective immunity in high-risk, hard-to-immunize populations.

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New Developments and Therapeutic Drug Monitoring Options in Costimulatory Blockade in Solid Organ Transplantation: A Systematic Critical Review

de Graav,

Udomkarnjananun,

Baan

et al. 2024

Therapeutic Drug Monitoring

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Purpose: In this review, the authors summarized the latest developments in costimulatory blockade to prevent rejection after solid organ transplantation (SOT) and discussed possibilities for future research and the need for therapeutic drug monitoring (TDM) of these agents. Methods: Studies about costimulatory blockers in SOT in humans or animal transplant models in the past decade (2014–2024) were systematically reviewed in PubMed, European Union clinical trials (EudraCT), and ClinicalTrials.gov. Results: Seventy-five registered clinical trials and 58 published articles were found on costimulation blockade of the CD28-CD80/86, CD40-CD40L, and OX40-OX40L pathways. Belatacept, an antagonist of the CD28-CD80/86 pathway, is the only approved costimulatory agent in SOT, hence accounting for most of the research. Other identified costimulatory blocking agents included abatacept and CD28 antagonists tegoprubart, dazodalibep, and TNX-1500. Although tegoprubart was unsuccessful in pancreas transplantation in nonhuman primates, trials in human kidney transplantation are underway. Dazodalibep trials faced recruitment challenges. TNX-1500 was unsuccessful in animal studies and is currently not pursued in humans. After discontinuation of iscalimab (CD40-CD154 pathway antagonist) in SOT, the alternatives, bleselumab and KPL404, showed promising results in kidney transplantation and cardiac xenotransplantation. Studies on secondary costimulatory pathway antagonists, such as OX40-OX40L, have only used animal models. Despite the low interindividual variability in pharmacokinetics (PK) in all studied agents, TDM could be useful for optimizing dosing in PK/pharmacodynamic (PD) studies. Conclusions: The routine use of costimulation blockade in SOT is hindered by problems in efficacy compared with the standard of care. Costimulatory inhibitors could be combined in a calcineurin inhibitor-free regimen. Future PK/pharmacodynamic studies in costimulatory agents and personalized medicine could warrant TDM of these agents.

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Survival Benefit of Solid-Organ Transplantation: 10-Year Update

Cited by 6 publications

References 36 publications

Relationship between the microenvironment and survival in kidney transplantation: a bibliometric analysis from 2013 to 2023

Relationship between the microenvironment and survival in kidney transplantation: a bibliometric analysis from 2013 to 2023

B and T Cell Responses to SARS-CoV-2 Vaccination in Kidney and Liver Transplant Recipients with and without Previous COVID-19

New Developments and Therapeutic Drug Monitoring Options in Costimulatory Blockade in Solid Organ Transplantation: A Systematic Critical Review

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