Survival comparison between intensive hemodialysis and transplantation in the context of the existing literature surrounding nocturnal and short-daily hemodialysis

Pauly, R. P.

doi:10.1093/ndt/gfs419

Cited by 17 publications

(16 citation statements)

References 21 publications

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“…This confirms the non-toxicity of both extracts and also that the kidney functions are intact since these two biochemical parameters are good markers of this function. 18 The blood glucose level obtained in all the treated and untreated rats indicates that the aqueous extracts of these two plants have no harmful effect on the pancreas. In addition, the plasma levels of alkaline phosphatase, triglycerides and total proteins are significantly decreased in rats treated with both aqueous extracts when compared to the control non-treated rats.…”

Section: Resultsmentioning

confidence: 84%

Evaluation of the effects of Corchorus olitorius L. and Carapa procera in the treatment of obesity

Adon¹,

Ackah

Yayé

et al. 2018

Int J Res Med Sci

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Background: The obesity remains a pathology today which expands. It leads in its wake much pathology with very serious consequences. It is therefore necessary to take steps to curb this nutritional pathology. Thus, two plant species including Carapa procera and Corchorus olitorius have been tested to assess their effect on this pathology.Methods: Aqueous extracts of Carapa procera bark and Corchorus olitorius roots were tested on rats and biochemical parameters were evaluated. Besides, a chemical characterization was led.Results: These plant extracts contain bioactive molecules that have a regressive activity on the plasma levels of cholesterol, triglyceride and LDL-cholesterol. These bioactive molecules increase the level of HDL-cholesterol. These 2 species are non-toxic on renal, hepatic and pancreatic functions in view of the values of urea, creatinine and blood glucose.Conclusions: Of these 2 extracts, the aqueous extract of Corchorus olitorius is more active.

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Section: Resultsmentioning

confidence: 84%

Evaluation of the effects of Corchorus olitorius L. and Carapa procera in the treatment of obesity

Adon¹,

Ackah

Yayé

et al. 2018

Int J Res Med Sci

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“…Comparing patient outcomes, the HR of mortality in the intensive dialysis group was close to half (HR ¼ 0.55) compared with the conventional dialysis group. Such improved patient outcomes have led Kjellstrand et al 4 and Pauly 17 to conclude that intensive HD results in a probability of survival that is similar between patients on intensive dialysis and those who have undergone deceased donor transplantation.…”

Section: Non-randomized Retrospective Cohort Trialsmentioning

confidence: 99%

Dialysis frequency versus dialysis time, that is the question

Hakim

Saha

2014

Kidney International

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We reviewed a number of prospective randomized and multiple retrospective cohort studies of different dialysis prescriptions: longer dialysis time, at a frequency of at least three times a week, or a frequency of daily hemodialysis with a shorter dialysis time. Interestingly, the retrospective analyses have generally found significant survival benefits in the intensive dialysis groups, whereas more modest effects were observed in the prospective randomized controlled trials. The reason for this discrepancy may be related to the retrospective nature of the studies and possible selection bias; for example, the patients who were prescribed more frequent dialysis may have had more difficulties with volume control or high blood pressure. In contrast, the randomized controlled trials of increased dialysis frequency, which have shown indirect and modest benefits in complex coprimary end points, have small sample sizes and are plagued with difficulties in recruitment and compliance with the randomly allocated more frequent dialysis. This review, which attempts to balance the potential benefits of more frequent dialysis with the burden on the patient's lifestyle, an increased risk of access malfunction, as well as societal costs of such intensive dialysis prescriptions, concludes in favor of the conventional three times per week dialysis (at a minimum) but at longer dialysis times than is currently prescribed based on the Kt/Vurea metric alone.

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“…This is collectively defined as any weekly dialysis dosage exceeding that of CHD. Intensive therapy includes nocturnal HD (NHD) (usually 4–6 times weekly, 6–8 h/session), and short daily HD (SDHD) (usually 5–7 times weekly, 1.5–3 h/session), performed either in‐center or at home …”

Section: Introductionmentioning

confidence: 99%

“…Intensive therapy includes nocturnal HD (NHD) (usually 4-6 times weekly, 6-8 h/session), and short daily HD (SDHD) (usually 5-7 times weekly, 1.5-3 h/session), performed either in-center or at home. 2 Despite the growing interest, the potential survival advantage of intensive dialysis is controversial. Although the majority of early studies showed a clear survival advantage compared to conventional therapy, more recent literature has been conflicting.…”

Section: Introductionmentioning

confidence: 99%

Survival comparisons of intensive vs. conventional hemodialysis: Pitfalls and lessons

Miller

Perl

Tennankore

2017

Hemodialysis International

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The optimal dose of hemodialysis (HD) has not yet been established. As a means of better approximating the physiology of native kidney function, there has been a growing interest in intensive HD (an increase in dialysis frequency and/or duration). Although many studies have demonstrated a survival benefit with intensive dialysis, results have been conflicting. This controversy stems from the challenges of randomizing patients to conventional vs. intensive HD modalities and, therefore, the reliance on observational comparisons that have been limited by varying definitions for intensive dialysis, differences in dialysis location and prescription, unavoidable treatment selection bias, and a potential lack of generalizability. This review will discuss the pitfalls and complexities surrounding survival comparisons with intensive HD, and identify important directions for future study.

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Survival comparison between intensive hemodialysis and transplantation in the context of the existing literature surrounding nocturnal and short-daily hemodialysis

Cited by 17 publications

References 21 publications

Evaluation of the effects of Corchorus olitorius L. and Carapa procera in the treatment of obesity

Evaluation of the effects of Corchorus olitorius L. and Carapa procera in the treatment of obesity

Dialysis frequency versus dialysis time, that is the question

Survival comparisons of intensive vs. conventional hemodialysis: Pitfalls and lessons

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