Survival difference among adult and pediatric mediastinal yolk sac tumors cases: A meta-analysis of case reports

Dabsha, Anas; Elkharbotly, Ismail A.M.H.; Yaghmour, Mohammad; Badr, Amr; Badie, Fady; Khairallah, Sherif; Esmail, Yomna M.; Hossny, Mohamed; Rizk, Amr; El-Demiry, Amr; Ghaly, Galal; Al-Thani, Shaikha; Demetres, Michelle; Mohamed, Abdelrahman; Villena-Vargas, Jonathan; Kamal, Mona; Rahouma, Mohamed

doi:10.1016/j.ejso.2024.108019

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…Notably, in many cases, authors choose a similar approach as in our case, with neo-adjuvant chemotherapy (most often BEP-regimen), followed by complete surgical resection [ 11 , 26 – 29 ]. More recently a meta-analysis was published on mediastinal yolk sac tumors revealing a poor prognosis with a median time to survival of 23 months for adult patients, 3-year overall survival of 24.4%, and 5-year overall survival of 23% [ 30 ]. On multivariate analysis the main predictors for favorable outcome were: undergoing surgery, receiving chemotherapy, and a more anterior localization of the tumor [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…More recently a meta-analysis was published on mediastinal yolk sac tumors revealing a poor prognosis with a median time to survival of 23 months for adult patients, 3-year overall survival of 24.4%, and 5-year overall survival of 23% [ 30 ]. On multivariate analysis the main predictors for favorable outcome were: undergoing surgery, receiving chemotherapy, and a more anterior localization of the tumor [ 30 ]. Furthermore, the authors claim that the most important cornerstones of the successful treatment of such malignancies are (1) early diagnosis (2) neoadjuvant chemotherapy and (3) surgical resection [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…On multivariate analysis the main predictors for favorable outcome were: undergoing surgery, receiving chemotherapy, and a more anterior localization of the tumor [ 30 ]. Furthermore, the authors claim that the most important cornerstones of the successful treatment of such malignancies are (1) early diagnosis (2) neoadjuvant chemotherapy and (3) surgical resection [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

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Extensive surgical resections for rare pleural neoplasms: a single-center experience with a yolk sac tumor and synovial sarcoma

Vandaele,

Van Slambrouck,

Schöffski

et al. 2024

World J Surg Onc

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Background Pleural neoplasms are rare and can be subdivided into pleural metastasis and primary pleural neoplasms. Non-mesothelioma primary pleural neoplasms are a diverse group of extremely rare pathologies. Case presentation In this case series, we describe the presentation and management of two rare primary pleural neoplasms. A first case describes a primary pleural yolk sac tumor treated with neoadjuvant chemotherapy, extended pleurectomy decortication, and hyperthermic intrathoracic chemotherapy. In a second case we describe the management of a primary pleural synovial sarcoma by neoadjuvant chemotherapy and extrapleural pneumonectomy. A complete resection was obtained in both cases and the post-operative course was uncomplicated. No signs of tumor recurrence were noted during follow-up in the first patient. In the second patient a local recurrence was diagnosed 6 months after surgery. Conclusion Neo-adjuvant chemotherapy followed by extensive thoracic surgery, including hyperthermic intrathoracic chemotherapy, is a feasible treatment strategy for non-mesothelioma primary pleural neoplasms, but careful follow-up is required.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Extensive surgical resections for rare pleural neoplasms: a single-center experience with a yolk sac tumor and synovial sarcoma

Vandaele,

Van Slambrouck,

Schöffski

et al. 2024

World J Surg Onc

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Primary mediastinal yolk sac tumor with multiple metastases on 18F-FDG PET/CT: A case report

Jing,

Zhang,

Liu

et al. 2024

Asian Journal of Surgery

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Current Trends in the Surgical Management of Yolk Sac Tumors

Wojtyś,

Kostopanagiotou,

Kordykiewicz

et al. 2024

Current Oncology

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Mediastinal yolk sac tumors (YST) constitute a highly malignant subtype of primary non-seminomatous germ cell tumors, which are often locally advanced and unresectable at diagnosis. Due to their rarity and aggressiveness, there is not yet a standard optimal treatment approach. A widely employed multimodal strategy involves neoadjuvant cisplatin-based combination chemotherapy followed by consolidation surgery. Tumor infiltration into the lungs and adjacent cardiovascular structures is common, such that surgical intervention typically requires extensive resections, performed either by sternotomy or thoracotomy. For this review, we extensively searched the PubMed and Embase medical databases, identifying articles describing surgical treatment of mediastinal yolk sac tumors. The current literature provides limited details regarding the utilized surgical procedures, leaving clinicians without comprehensive guidance about the demanding nature of these resections. Here, we present a narrative description of the range of current surgical procedures. By highlighting these techniques, we provide a comprehensive overview of the current surgical landscape, thereby helping clinicians understand the potential complexities and considerations involved in managing these rare and aggressive tumors.

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Survival difference among adult and pediatric mediastinal yolk sac tumors cases: A meta-analysis of case reports

Cited by 3 publications

References 19 publications

Extensive surgical resections for rare pleural neoplasms: a single-center experience with a yolk sac tumor and synovial sarcoma

Extensive surgical resections for rare pleural neoplasms: a single-center experience with a yolk sac tumor and synovial sarcoma

Primary mediastinal yolk sac tumor with multiple metastases on 18F-FDG PET/CT: A case report

Current Trends in the Surgical Management of Yolk Sac Tumors

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