Survival following radiotherapy for post-surgical locoregional recurrence of non-small cell lung cancer

Leung, Janice M.; Ball, David; Worotniuk, T.; Laidlaw, C.

doi:10.1016/0169-5002(95)00490-4

Cited by 31 publications

(26 citation statements)

References 5 publications

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“…The 5-year and median OS results for those with recurrence in our study appeared to be better than those reported by others, which have ranged from 4% to 12.5% and 8.1 to 14.0 months, respectively (9)(10)(11)(12)(13)(14)(15)(16)(17), and the survival of the newly diagnosed patients was comparable to those reported for 1996-2004 in the 17 Surveillance, Epidemiology, and End Results geographic areas (5-year survival rate, 15.2%; available from: http://seer.cancer.gov/statfacts/html/lungb. html).…”

Section: Discussioncontrasting

confidence: 71%

“…The data on treatment outcomes after RT are limited for postresection recurrent NSCLC (9)(10)(11)(12)(13)(14)(15)(16)(17), especially relative to the survival outcomes of newly diagnosed NSCLC patients treated with RT-based regimens (10,11). The purpose of the present study was to evaluate the utility of salvage RT for recurrent NSCLC after surgical resection and to compare the survival statistics of these patients with those of newly diagnosed NSCLC patients.…”

Section: Introductionmentioning

confidence: 97%

See 1 more Smart Citation

Comparative Survival in Patients With Postresection Recurrent Versus Newly Diagnosed Non–Small-Cell Lung Cancer Treated With Radiotherapy

Cai

Wang

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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Section: Discussioncontrasting

confidence: 71%

Section: Introductionmentioning

confidence: 97%

Comparative Survival in Patients With Postresection Recurrent Versus Newly Diagnosed Non–Small-Cell Lung Cancer Treated With Radiotherapy

Cai

Wang

et al. 2010

International Journal of Radiation Oncology*Biology*Physics

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“…Although regional failures occur in up to 15% of these patients, 5–7 a minority will be candidates for further thoracic radiotherapy. Many will have synchronous local or distant failure or a performance status that precludes additional treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Their report is consistent with earlier reports for radiotherapy salvage after surgery and with our current series. 3,4,7 Therefore, given the near certainty of progression with chemotherapy treatment and the postoperative radiotherapy salvage results, we routinely evaluate and treat patients with IMF with radiotherapy as there is some hope for salvage. 6 …”

Section: Discussionmentioning

confidence: 99%

Management of Mediastinal Relapse after Treatment with Stereotactic Body Radiotherapy or Accelerated Hypofractionated Radiotherapy for Stage I/II Non–Small-Cell Lung Cancer

Kilburn

Lester

Lucas

et al. 2014

Journal of Thoracic Oncology

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Purpose/Objective(s) Regional failures occur in up to 15% of patients treated with stereotactic body radiotherapy (SBRT) for stage I/II lung cancer. This report focuses on the management of the unique scenario of isolated regional failures. Methods Patients treated initially with SBRT or accelerated hypo-fractionated radiotherapy were screened for curative intent treatment of isolated mediastinal failures (IMFs). Local control, regional control, progression-free survival, and distant control were estimated from the date of salvage treatment using the Kaplan–Meier method. Results Among 160 patients treated from 2002 to 2012, 12 suffered IMF and were amenable to salvage treatment. The median interval between treatments was 16 months (2–57 mo). Median salvage dose was 66 Gy (60–70 Gy). With a median follow-up of 10 months, the median overall survival was 15 months (95% confidence interval, 5.8–37 mo). When estimated from original treatment, the median overall survival was 38 months (95% confidence interval, 17–71 mo). No subsequent regional failures occurred. Distant failure was the predominant mode of relapse following salvage for IMF with a 2-year distant control rate of 38%. At the time of this analysis, three patients have died without recurrence while four are alive and no evidence of disease. High-grade toxicity was uncommon. Conclusions To our knowledge, this is first analysis of salvage mediastinal radiation after SBRT or accelerated hypofractionated radiotherapy in lung cancer. Outcomes appear similar to stage III disease at presentation. Distant failures were common, suggesting a role for concurrent or sequential chemotherapy. A standard full course of external beam radiotherapy is advisable in this unique clinical scenario.

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“…The survival outcomes were quite variable of 10-40% at 2-year because 1970's and 1980's and most studies had only a small number of patients, with diverse RT dose schedules being used. Among these, few studies reported that post-resection recurrent NSCLC patients treated with salvage RT have survival comparable to that of newly diagnosed patients treated with radical RT 14,17,22. Therefore, salvage RT would be actively considered in patients with inoperable disease.…”

Section: Introductionmentioning

confidence: 99%

High Dose Involved Field Radiation Therapy as Salvage for Loco-Regional Recurrence of Non-Small Cell Lung Cancer

et al. 2012

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PurposeTo determine the effectiveness of salvage radiation therapy (RT) in patients with loco-regional recurrences (LRR) following initial complete resection of non-small cell lung cancer (NSCLC) and assess prognostic factors affecting survivals.Materials and MethodsBetween 1994 and 2007, 64 patients with LRR after surgery of NSCLC were treated with high dose RT alone (78.1%) or concurrent chemo-radiation therapy (CCRT, 21.9%) at Samsung Medical Center. Twenty-nine patients (45.3%) had local recurrence, 26 patients (40.6%) had regional recurrence and 9 patients (14.1%) had recurrence of both components. The median RT dose was 54 Gy (range, 44-66 Gy). The radiation target volume included the recurrent lesions only.ResultsThe median follow-up time from the start of RT in survivors was 32.0 months. The rates of in-field failure free survival, intra-thoracic failure free survival and extra-thoracic failure free survival at 2 years were 52.3%, 33.9% and 59.4%, respectively. The median survival after RT was 18.5 months, and 2-year overall survival (OS) rate was 47.9%. On both univariate and multivariate analysis, the interval from surgery till recurrence and CCRT were significant prognostic factors for OS.ConclusionThe current study demonstrates that involved field salvage RT is effective for LRR of NSCLC following surgery.

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Survival following radiotherapy for post-surgical locoregional recurrence of non-small cell lung cancer

Cited by 31 publications

References 5 publications

Comparative Survival in Patients With Postresection Recurrent Versus Newly Diagnosed Non–Small-Cell Lung Cancer Treated With Radiotherapy

Comparative Survival in Patients With Postresection Recurrent Versus Newly Diagnosed Non–Small-Cell Lung Cancer Treated With Radiotherapy

Management of Mediastinal Relapse after Treatment with Stereotactic Body Radiotherapy or Accelerated Hypofractionated Radiotherapy for Stage I/II Non–Small-Cell Lung Cancer

High Dose Involved Field Radiation Therapy as Salvage for Loco-Regional Recurrence of Non-Small Cell Lung Cancer

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