Survival From Severe Thoracic Trauma Is Associated With Supranormal Circulatory Function and Increased Fluid Balance

Conventional neurocritical care and cerebral oxygenation after traumatic brain injury

“…Several but not all studies support the hypothesis that this concept of resuscitation to maximize optimal tissue O 2 may reduce the mortality rate and the incidence of major organ dysfunction in the severely injured patient. 6,45,53,54,63 It is clear from these studies that the greatest benefit is observed in the sickest patients and in those in whom oxygenation is initiated early during resuscitation. 32,53,54 The relationship between early "neuroprotection," both in laboratory and clinical studies, and prevention of secondary brain injury is well known.…”