Survival in extra-orbital metastatic retinoblastoma: treatment results

Leal-Leal, Carlos; Rivera-Luna, Roberto; Flores-Rojo, M. E.; Juárez-Echenique, Juan Carlos; Ordaz, Juan C.; Amador-Zarco, Jorge

doi:10.1007/s12094-006-0093-x

Cited by 53 publications

(41 citation statements)

References 21 publications

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“…Encouraging results have been reported for the treatment of retinoblastoma that is disseminated to the orbit or the preauricular lymph nodes has resulted in disease-free survival rates over 70% [41]. Different chemotherapy combinations have been used to treat overt extraocular retinoblastoma; most regimens include a platinum derivative; an alkylating agent, such as cyclophosphamide or ifosfamide, etoposide, and anthracyclines [22,41,42]. A low intensity regimen using these agents led to 56% survival at 30 months in Mali [13].…”

Section: Treating Patients With Overt Extraocular Diseasementioning

confidence: 99%

“…Results of using conventional chemotherapy and irradiation for distant metastatic disease have been disappointing in developing countries [42,43]. Patients with metastatic disease outside the central nervous system (CNS) may be cured with high-dose chemotherapy and stem cell rescue [8,44]; however, these treatments usually are not available in LICs or most lower MICs.…”

Section: Treating Patients With Overt Extraocular Diseasementioning

confidence: 99%

“…Patients with metastatic disease outside the central nervous system (CNS) may be cured with high-dose chemotherapy and stem cell rescue [8,44]; however, these treatments usually are not available in LICs or most lower MICs. In cases with initial CNS involvement, subsequent relapse in the CNS often occurs after an initial response and ultimately causes death [42].…”

Section: Treating Patients With Overt Extraocular Diseasementioning

confidence: 99%

See 2 more Smart Citations

Strategies to manage retinoblastoma in developing countries

Chantada

Qaddoumi

Canturk³

et al. 2010

Pediatric Blood & Cancer

131

109

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Survival of retinoblastoma is >90% in developed countries but there are significant differences with developing countries in stage at presentation, available treatment options, family compliance, and survival. In low‐income countries (LICs), children present with advanced disease, and the reasons are socioeconomic and cultural. In middle‐income countries (MICs), survival rates are better (>70%), but there is a high prevalence of microscopically disseminated extraocular disease. Programs for eye preservation have been developed, but toxicity‐related mortality is higher. Although effective treatment of microscopically extraocular disease improved the outcome, worldwide survival will be increased only by earlier diagnosis and better treatment adherence. Pediatr Blood Cancer 2011;56:341–348. © 2010 Wiley‐Liss, Inc.

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Section: Treating Patients With Overt Extraocular Diseasementioning

confidence: 99%

Section: Treating Patients With Overt Extraocular Diseasementioning

confidence: 99%

Section: Treating Patients With Overt Extraocular Diseasementioning

confidence: 99%

See 1 more Smart Citation

Strategies to manage retinoblastoma in developing countries

Chantada

Qaddoumi

Canturk³

et al. 2010

Pediatric Blood & Cancer

131

109

View full text Add to dashboard Cite

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“…Highly individualized aggressive treatments involving a combination of radical surgery, chemotherapy and external beam radiation therapy is required for cases with orbital retinoblastoma (International Retinoblastoma Staging System stage III) and extra-orbital metastatic retinoblastoma [15,16]. However, due to poor compliance and the advanced stage of the disease, very high mortality rates occur, in spite of the use of combining treatment regimens [17]. It should be noted that retinoblastoma represents a very rare human malignancy where definitive treatment can be started without any confirmed histopathological diagnosis, as imaging plays an important role in the corrective diagnosis of this condition.…”

Section: Discussionmentioning

confidence: 99%

Concomitant Intraocular and Orbital Space-Occupied Lesions

Yan¹,

Shen²,

Chen³

2016

Optom open access

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Purpose/background: Concomitant intraocular and orbital space-occupied lesions are relatively rare and this is the first report stressing the underlying causes of concomitant intraocular and intraorbital lesions. In this paper, we present cases showing both intraocular and orbital soft tissue masses and highlight their clinical, pathological and imaging features. Materials and methods:A retrospective review was performed on cases with both intraocular and orbital spaceoccupied lesions who were treated at the Zhongshan Ophthalmic Center, of Sun Yat-sen University, China between Jan 1, 2000 and Dec 31, 2011. Results:From an initial retrospective review of 1543 patients with a diagnosis of intraocular and/or orbital spaceoccupied lesions, 8 patients (4 males and 4 females) with a coexistence of both intraocular and orbital mass lesions were identified. Patients' ages ranged from 22 months to 71 years (median = 3.0 years) and included 5 cases of retinoblastoma, 1 case of idiopathic inflammatory pseudotumor, 1 case of T-cell lymphoma, and 1 case of SturgeWeber syndrome.Conclusions: Based upon these findings, the presence of a lesion involving both the orbit and eye should be included when a diagnosis of retinoblastoma, idiopathic inflammatory pseudotumor, lymphoma, and/or SturgeWeber syndrome is proposed.

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“…3 Retinoblastoma has a tendency for cranial hemorrhagic metastases. 4 Yet, no case has been seen in literature as cerebellar metastasis of Rb and subspecified to infratentorial localization.…”

Section: Introductionmentioning

confidence: 99%

Posterior fossa metastasis of retinoblastoma accompanying a supratentorial second focus in a child: a case report

et al. 2017

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The central nervous system, as a metastatic focus, has an extreme predisposition to retinoblastoma and has been indicated as the most common site for this disease. Herein, we report a 4-year-old girl presenting with multiple cranial metastases of retinoblastoma. To our knowledge, this presented case is valuable and significant in terms of being reported as the first cerebellar metastasis of retinoblastoma in the literature and removing this lesion together with supratentorial focus in a single operation with a single skin incision.

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Survival in extra-orbital metastatic retinoblastoma: treatment results

Abstract: In our experience, metastatic RB has a very high mortality rate in spite of the use of different chemotherapy regimens.

Cited by 53 publications

References 21 publications

Strategies to manage retinoblastoma in developing countries

Strategies to manage retinoblastoma in developing countries

Concomitant Intraocular and Orbital Space-Occupied Lesions

Posterior fossa metastasis of retinoblastoma accompanying a supratentorial second focus in a child: a case report

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