Survival in severe pulmonary hypertension due to chronic lung disease: influence of in‐hospital platelet distribution width

Wang, Lan; Shen, Li; Zhao, Yusheng; Pudasaini, Bigyan; Zhao, Qin‐Hua; Gong, Shan Shan; Zhang, Rui; Yuan, Ping; He, Jing; Luo, Ci‐Jun; Qiu, Hong‐Ling; Jiang, Rong

doi:10.1177/20458940211026484

Cited by 2 publications

(2 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Platelet distribution width (PDW), a measure of platelet activation, has been proposed as a risk predictor of PAH (71). In patients with severe HPH, in-hospital PDW was independently related to all-cause death, suggesting that PDW may be a predictive indicator for platelet activation and severity (72). The platelet-to-lymphocyte ratio (PLR) is a novel inflammatory marker that can be used to predict inflammation and mortality in various diseases.…”

Section: Plateletsmentioning

confidence: 99%

Inflammation and immunity in the pathogenesis of hypoxic pulmonary hypertension

Wuren

2023

Front. Immunol.

View full text Add to dashboard Cite

Hypoxic pulmonary hypertension (HPH) is a complicated vascular disorder characterized by diverse mechanisms that lead to elevated blood pressure in pulmonary circulation. Recent evidence indicates that HPH is not simply a pathological syndrome but is instead a complex lesion of cellular metabolism, inflammation, and proliferation driven by the reprogramming of gene expression patterns. One of the key mechanisms underlying HPH is hypoxia, which drives immune/inflammation to mediate complex vascular homeostasis that collaboratively controls vascular remodeling in the lungs. This is caused by the prolonged infiltration of immune cells and an increase in several pro-inflammatory factors, which ultimately leads to immune dysregulation. Hypoxia has been associated with metabolic reprogramming, immunological dysregulation, and adverse pulmonary vascular remodeling in preclinical studies. Many animal models have been developed to mimic HPH; however, many of them do not accurately represent the human disease state and may not be suitable for testing new therapeutic strategies. The scientific understanding of HPH is rapidly evolving, and recent efforts have focused on understanding the complex interplay among hypoxia, inflammation, and cellular metabolism in the development of this disease. Through continued research and the development of more sophisticated animal models, it is hoped that we will be able to gain a deeper understanding of the underlying mechanisms of HPH and implement more effective therapies for this debilitating disease.

show abstract

Section: Plateletsmentioning

confidence: 99%

Inflammation and immunity in the pathogenesis of hypoxic pulmonary hypertension

Wuren

2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…89 Recent studies have shown that PDW can be used to predict poor prognosis in many diseases. [90][91][92][93] Enawgaw and coworkers 94 conducted a cross-sectional comparative study including a total of 126 hypertensive and 126 normotensive individuals. They found that PDW was significantly higher in the hypertensive group (12.6 ± 1.8 fl) than in the apparently healthy normotensive group (12.0 ± 1.7 fl; P = .007).…”

Section: Platelet Distribution Width (Pdw)mentioning

confidence: 99%

The Predictive Role of Hematological Parameters in Hypertension

Meng

Sun

et al. 2023

Angiology

View full text Add to dashboard Cite

Hypertension (HT) is a common chronic disease that often causes target-organ damage and severe complications, contributing to cardiovascular morbidity and mortality worldwide. Accumulating evidence suggests that inflammation plays a prominent role in the initiation and progression of HT. Multiple inflammatory biomarkers have been proposed to predict HT. Several new hematological parameters can reflect the inflammatory response and platelet activation. The major advantage of hematological parameters over conventional inflammatory markers is that they are relatively inexpensive and easily obtained from routine blood tests. Numerous studies have investigated several hematological parameters for their utility as predictive biomarkers for the diagnosis and prognosis of HT. Among them, the neutrophil to lymphocyte ratio (NLR), monocyte to high density lipoprotein cholesterol ratio (MHR), red cell distribution width (RDW), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV), platelet distribution width (PDW), and systemic immune-inflammation index (SII) have recently received attention. We searched PubMed and Embase databases (up to September 18, 2022) to assess the relationships between hematological parameters and HT. This review discusses the diagnostic and prognostic value of these hematological parameters in HT, providing an important basis for early screening, risk stratification, and optimal management of hypertensive patients.

show abstract

Survival in severe pulmonary hypertension due to chronic lung disease: influence of in‐hospital platelet distribution width

Cited by 2 publications

References 32 publications

Inflammation and immunity in the pathogenesis of hypoxic pulmonary hypertension

Inflammation and immunity in the pathogenesis of hypoxic pulmonary hypertension

The Predictive Role of Hematological Parameters in Hypertension

Contact Info

Product

Resources

About