Survival, lung clearance, dosimetry and gross pathology of rats exposed to either NpO 2 or PuO 2 aerosols

Abstract

NpO2 appears much more toxic than PuO2. Before saturation, lung tumour incidence increased nearly linearly with dose, the slope of the curve for NpO2 being about twice as steep as that for PuO2.

Late-Occurring Pulmonary Pathologies Following Inhalation of Mixed Oxide (Uranium + Plutonium Oxide) Aerosol in the Rat

“…For either powder adenocarcinomas were the most frequently observed, and at higher doses squamous cell carcinomas were prevalent. These findings are in agreement with previous studies concerning plutonium oxide aerosol inhalation (Dudoignon et al 2001). Adenosquamous cell carcinomas were rarely observed.…”

“…; 40 mg kg Ϫ1 ) and thorax-associated radioactivity measured by x or gamma spectrometry. This procedure was repeated at different times later and at euthanasia in order to estimate the lifetime lung dose taking into account animal body and lung weight as carried out in previous studies with plutonium oxide or neptunium oxide (Dudoignon et al 2001).…”

“…); 50 mg kg Ϫ1 ] and exsanguinated from the dorsal aorta. All experiments were carried out according to French regulations for animal experimentation under the European directive (2001( -246 6 June 2001.…”

ICRP Publication 141: Occupational Intakes of Radionuclides: Part 4

“…The high IDLD may well have resulted in impaired lung clearance by particle transport, as observed by Dudoignon et al. (1999, 2001) at similar exposure levels. (632) Dudoignon et al. (1999, 2001) investigated lung carcinogenesis in rats following inhalation of 237 NpO 2 by rats, with average IDLD ranging from 0.1 to 7 kBq.…”

“…The high IDLD may well have resulted in impaired lung clearance by particle transport, as observed by Dudoignon et al. (1999, 2001) at similar exposure levels.…”