Survival of a surgical series of lung cancer patients with synchronous multiple ground-glass opacities, and the management of their residual lesions

Shimada, Yoshihisa; Saji, Hisashi; Otani, Keishi; Maehara, Sachio; Maeda, Junichi; Yoshida, Kôichi; Kato, Yasufumi; Hagiwara, Masaru; Kakihana, Masatoshi; Kajiwara, Naohiro; Ohira, Tetsuya; Akata, Soichi; Ikeda, Norihiko

doi:10.1016/j.lungcan.2015.02.016

Cited by 76 publications

(67 citation statements)

References 25 publications

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“…Lee and colleagues [15] suggested that the surgical approach of pGGO with pathological types of AIS and MIA has been recommended for sublobar resection rather than lobectomy. There are also reports [11,16,17] in the literature that multiple GGO patients with surgical resection,the prognosis is satisfactory, even sub-lobectomy does not affect the prognosis. In view of the good prognosis of multiple GGOs [18][19][20], we suggest that sub-lobectomy should be performed as much as possible for patients with multiple GGOs in the same period of surgery, which can ensure the prognosis and make the patient better quality of life.…”

Section: Discussionmentioning

confidence: 95%

Single-center experience of simultaneous bilateral uni-portal video-assisted thoracoscopic surgery for multiple ground-glass opacities

Zhang

et al. 2020

J Cardiothorac Surg

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Background: There is an increasing incidence rate of ground-glass opacity (GGO), especially for multiple GGOs (≥2). Whether it is safe and feasible to have bilateral simultaneous surgical resection remains unknown. The purpose of this study is to summarize the experience of surgical resection of patients with multiple GGOs in our Hospital in recent years, and to discuss the above questions. Methods: Clinical datas of patients who underwent one-stage bilateral uni-portal VATS resections of multiple pulmonary ground glass opacities and had routine pathological examination were collected from May 2016 to May 2019 in our hospital. Results: A total of 34 patients underwent simultaneous bilateral surgical resection of multiple GGO lesions, 28 were women,6 were men, the average age of total patients was 57.9 ± 6.7 years. All patients underwent bilateral uniportal video-assisted thoracoscopic surgery (Uni-portal VATS), the average intraoperative blood loss was 100.9 ± 67.7 ml, the average operation time was 140 ± 74.8 min, the average thoracic drainage time was 2.8 ± 3.1 days, and the average postoperative hospital stay was 4.2 ± 4.3 days. Postoperative complications including: 2 cases of infection, 3 cases of atrial fibrillation, and 5 cases of persistent air leakage for more than 3 days. All of them improved after treatment, and there were no serious complications and deaths in perioperative period. A total of 76 GGO lesions were resected, with a total malignancy rate of 81.6%, including 40 were pure GGO, of which 28 were malignant (70%), and the average diameter of them were 9.6 ± 3.8 mm; 36 were mixed GGO, of which 34 were malignant (94.4%), the average diameter of them were 15.6 ± 6.6 mm.Mean postoperative follow-up was 28.4 (range, 3-39) months. There was neither recurrence nor deaths at final follow-up. Conclusion: The malignancy rate of multiple GGOs is high. Therefore, when the lung function is allowed,one-stage bilateral uni-portal VATS can be considered. According to experience of main surgeon and the frozen biopsy, either sub-lobar resection or lobectomy was acceptable. The risk of postoperative complications and the prognosis were optimal.

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Section: Discussionmentioning

confidence: 95%

Single-center experience of simultaneous bilateral uni-portal video-assisted thoracoscopic surgery for multiple ground-glass opacities

Zhang

et al. 2020

J Cardiothorac Surg

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“…The mechanism probably involves the decrease in β-catenin transcription and translation. Cisplatin and any other first-line chemotherapy drug hold the disadvantage of strong toxicity and side effects; non-specificity of drug action is a reason for this phenomenon, thus limiting clinical application33. By contrast, the small-molecule inhibitor BHX targets tumor cells activated by the Wnt signaling pathway but only affects normal cells activated by the same pathway to a lower extent.…”

Section: Discussionmentioning

confidence: 99%

BHX Inhibits the Wnt Signaling Pathway by Suppressing β-catenin Transcription in the Nucleus

Ding

Wang

et al. 2016

Sci Rep

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BHX (N-(4-hydroxybenzyl)-1,3,4-triphenyl-4,5-dihydro-1H-pyrazole-5-carboxamide), a Wnt signaling pathway inhibitor, effectively inhibits tumor cell growth, but the underlying mechanism is unclear. Thus, we aim to investigate the effects and associated mechanism of BHX action on A549 and MCF-7 cell lines. In our study, MTT(3-[4,5-dimethyl-2-thiazolyl]-2,5-diphenyl-2H-tetrazolium bromide) and xenograft model assay indicated that cell growth was inhibited by BHX at a range of concentrations in vitro and in vivo. The expression of β-catenin and Wnt signaling pathway downstream target genes were decreased evidently under BHX treatment. Flow cytometry also revealed that BHX treatment significantly induced G1 arrest. Further analysis showed that BHX lowered the transcriptional level of β-catenin. In conclusion, BHX inhibited the nuclear synthesis of β-catenin, thereby suppressing the Wnt signaling pathway and further inhibiting tumor growth and proliferation.

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“…Lung adenocarcinomas with ground glass components have been hypothesized to behave less aggressively than solid nodules based on retrospective evidence; however, it has been observed nonetheless that a subset of ground glass-associated malignancies continue to show clinical progression [6,[15][16][17][18]. Our ability to preoperatively identify lesions that aggressively progress is limited.…”

Section: Commentmentioning

confidence: 99%

Clinicoradiographic Predictors of Aggressive Biology in Lung Cancer With Ground Glass Components

Nelson

Godoy

Benveniste

et al. 2018

The Annals of Thoracic Surgery

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Survival of a surgical series of lung cancer patients with synchronous multiple ground-glass opacities, and the management of their residual lesions

Cited by 76 publications

References 25 publications

Single-center experience of simultaneous bilateral uni-portal video-assisted thoracoscopic surgery for multiple ground-glass opacities

Single-center experience of simultaneous bilateral uni-portal video-assisted thoracoscopic surgery for multiple ground-glass opacities

BHX Inhibits the Wnt Signaling Pathway by Suppressing β-catenin Transcription in the Nucleus

Clinicoradiographic Predictors of Aggressive Biology in Lung Cancer With Ground Glass Components

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