Survival of biphasic pulmonary blastoma

Liman, Şerife Tuba; Altınok, Tamer; Topçu, Salih; Taştepe, Abdullah İrfan; Uzar, Ali İhsan; Demircan, Sedat; Demırağ, Funda

doi:10.1016/j.rmed.2005.10.026

Cited by 34 publications

(31 citation statements)

References 15 publications

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“…Koss et al [8], reported a mean survival of 33 months in 66 resected cases compared to 2 months in 17 patients with unresected disease. Liman et al [9], reported that resection of small tumors which do not have any lymph node involvement can provide better survival without any additional treatment. Limited resections do better than pneumonectomies, but wedge resection should be avoided.…”

Section: Discussionmentioning

confidence: 99%

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Classical Biphasic Pulmonary Blastoma: A Case Report

Zidane¹,

Arsalane²,

Elktaibi³

et al. 2016

Arch Pulmonol Respir Care

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Pulmonary blastomas are a rare aggressive neoplasms comprising 0.25-0.5% of all primary lung tumors and portend a poor prognosis. Recent World Health Orgnisation (WHO) reclassifications separated well differentiated fetal adenocarcinoma and pleuropulmonary blastoma from classic biphasic pulmonary blastoma which is now among carcinomas with pleomorphic, sarcomatoid or sarcomatous elements. The clinical and radiologic features are nonspecific. Surgery is the standard treatment and the efficacy of adjuvant chemotherapy and radiotherapy has not yet been established. We present a case of classic biphasic pulmonary blastoma in a 52-year old male and review the literature.for left pleural tuberculosis treated in 1988. On examination he looked well, had no clubbing. Baseline investigations were done, which included complete blood count, renal function tests, and liver function tests; all were within the normal range. Chest X-ray showed a well-demarcated mass projected over the right hilum. A subsequent chest computed tomography scan with intra-venous contrast (Figures 1,2) confirmed a well-defined 3.8 × 2.5 cm mass arising from the medial segment of the middle lobe. It demonstrated heterogeneous contrast enhancement with few necrotic foci. The mass abutted the mediastinal pleura with no sign of invasion of left atrium. There was no evidence of lymphadenopathy. The liver and adrenal glands appeared normal. CT guided biopsy was done and the smear revealed a biphasic neoplasm composed of epithelial and mesenchymal components suggestive of pulmonary blastoma. CT abdomen and bone scintigraphy showed no evidence of distant metastasis. The patient underwent a middle lobectomy with hilar and mediastinal lymph node dissection. The histopathology of the specimen confirmed the diagnosis of pulmonary blastoma without involvement of the lymph nodes. Post-operative course was uneventful and the patient was discharged on the 4th postoperative day. Due to the lack of certain poor prognostic factors like tumor size IntroductionPulmonary blastomas are a rare aggressive neoplasms comprising 0.25-0.5% of all primary lung tumors. They display a biphasic histology with mesenchymal and epithelial components whose features mimic embryological lung tissues before 4 months gestation. Since the first report by Barrett & Barnard [1], in 1945, over a hundred cases of pulmonary blastoma are reported in the literature. They are currently subdivided in three categories: well differentiated fetal adenocarcinoma, pleuropulmonary blastoma and classic biphasic pulmonary blastoma (CBPB). Surgery is the standard treatment and the efficacy of adjuvant chemotherapy and radiotherapy has not yet been established. We present a new case of this rare lung cancer. ObservationA 52-year-old man presented to the outpatient department with right chest pain of 3 months duration. He denied hemoptysis, dyspnea, fever or weight loss. His past medical history was significant

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Section: Discussionmentioning

confidence: 99%

“…Unfortunately, 43% of tumors recur within 1 year with a propensity for sites such as brain and Mediastinum [8]. Recurrence tends to occur within 1 year after diagnosis or not at all [9].…”

Section: Discussionmentioning

confidence: 99%

Classical Biphasic Pulmonary Blastoma: A Case Report

Zidane¹,

Arsalane²,

Elktaibi³

et al. 2016

Arch Pulmonol Respir Care

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“…The prognosis reported in the literature is generally poor, with limited survival within 2-3 years from diagnosis. The difference in survival rate depends on mediastinal node involvement and over the last ten years a better prognosis has been shown with preoperative neoadjuvant chemotherapy [14,16] . In a case of N2 disease, postoperative adjuvant radiation therapy and chemotherapy based on cisplatin and etoposide are considered the treatments of choice [14,17,18] .…”

Section: Discussionmentioning

confidence: 99%

Adult pulmonary blastoma: Report of an unusual malignant lung tumor

Magistrelli¹

2014

WJCO

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Pulmonary blastoma is an uncommon lung malignancy, usually presenting itself as a large chest mass causing pain, hemoptysis, cough and dyspnea; however, it is asymptomatic in up to 40% of patients. We present the case and suggestive images of a 37-year-old non-smoking lady with a monophasic pulmonary blastoma located in the lower lobe of the left lung who underwent a left posterolateral thoracotomy with lower lobectomy, hilar and mediastinal node dissection, followed by chemo and radiation therapy. After 36 mo, there is no disease progression and the patient is in good health, clinically stable and without significant chest pain. Core tip: Pulmonary blastoma is a rare condition and diagnosis may be difficult to obtain. It is important to underline that the appropriate management of this unusual type of lesion can be achieved only by a multidisciplinary specialized team, able to plan the correct integrated strategy based on aggressive surgery and chemo-radiation therapy.Magistrelli P, D'Ambra L, Berti S, Bonfante P, Francone E, Vigani A, Falco E. Adult pulmonary blastoma: Report of an unusual malignant lung tumor.

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“…Distant metastases are frequent in the liver, brain and bone. It is known very little about the physiology of this tumor [27]. This is the first work that describes the establishment and the phenotypic characteristics of a cell line of human pulmonary blastoma.…”

Section: Discussionmentioning

confidence: 99%