2002
DOI: 10.1002/neu.10002
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Survival of bundleless hair cells and subsequent bundle replacement in the bullfrog's saccule

Abstract: Our senses of hearing and balance depend upon hair cells, the sensory receptors of the inner ear. Millions of people suffer from hearing and balance deficits caused by damage to hair cells as a result of exposure to noise, aminoglycoside antibiotics, and antitumor drugs. In some species such damage can be reversed through the production of new cells. This proliferative response is limited in mammals but it has been hypothesized that damaged hair cells might survive and undergo intracellular repair. We examined… Show more

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Cited by 96 publications
(82 citation statements)
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“…When HCs are killed by aminoglycoside antibiotics, our data are consistent with previous studies showing that SCs constrict the apical portion of HCs. [13][14][15]17,33,34 Phagosome formation has previously been reported in immature avian utricles 15 and our study is the first to use live imaging to examine the formation of basket-like, F-actin-rich phagosomes in the mature mammalian inner ear. We followed individual HCs over time, as they lost membrane integrity, internalized TOTO-3, and were encapsulated and degraded by neighboring SCs.…”
Section: Discussionmentioning
confidence: 59%
“…When HCs are killed by aminoglycoside antibiotics, our data are consistent with previous studies showing that SCs constrict the apical portion of HCs. [13][14][15]17,33,34 Phagosome formation has previously been reported in immature avian utricles 15 and our study is the first to use live imaging to examine the formation of basket-like, F-actin-rich phagosomes in the mature mammalian inner ear. We followed individual HCs over time, as they lost membrane integrity, internalized TOTO-3, and were encapsulated and degraded by neighboring SCs.…”
Section: Discussionmentioning
confidence: 59%
“…Alexa-488-conjugated phalloidin labeling of the hair bundle and cuticular plate enabled determination of the number of surviving hair cells. Although hair cell bodies can survive ototoxic treatment without their hair bundles (Gale et al 2002), cleavage of the hair bundle is a cytotoxic event and the surviving cell body would be indicated by GTTR fluorescence. After exposure to GTTR for 1 h, followed by 4 h of recovery, the number of surviving neuromast hair cells decreased ( Fig.…”
Section: Gttr Enters Zebrafish Neuromast Hair Cells and Is Toxicmentioning
confidence: 99%
“…The amphibian is a frequent model for investigations of the ear, including evolutionary or comparative studies (Fritzsch and Wake, 1988;Fritzsch, 1990;Reiss, 1997), anatomic or histologic studies (Diaz et al, 1995;Gao et al, 1998;Gale et al, 2000), or studies that focus on questions of development or regeneration (Wiederhold et al, 1995;Gallagher et al, 1996;Lopez-Anaya et al, 1997;Bever and Fekete, 1999;Horowitz et al, 2001;Kil and Collazo, 2001;Gale et al, 2002). The purpose of this project was to provide an atlas that would illustrate the morphogenetic events of the developing normal inner ear and that could serve as a basis for phenotype identification in experimentally manipulated ears.…”
Section: Introductionmentioning
confidence: 99%