Survival of Cutaneous Homografts after Transplantation of Lymph Nodes immunized against the Host

The Role of Humoral Antibodies in Rejection of Skin Homografts in Rabbits

“…First, the demonstration by Mitchison (79,80), others (11,(81)(82)(83), that transplantation immunity can be transferred from one animal to another by means of sensitized lymphoid cells. There isno doubt that transplantation immunity can be transferred by means of cells, but since the same cells have been shown to be capable of antibody synthesis such an experiment represents no proof of the ultimate mechanism of rejection.…”

Prolonged survival of H-2 incompatible skin allografts on F1 animals treated with parental lymphoid cells

“…Although dramatic changes occur in the lymphoid organs as a result of a GVH reaction, relatively little is known about the immunological competence of an animal experiencing such a reaction. In situations where a GVH reaction existed it has been reported that allograft rejection in mice (Howard and Woodruff, 1961) and rabbits (Vrubel, 1961) as well as humoral antibody production in mice (Blaese, Martinez and Good, 1964) were impaired. Adoptively transferred immunity was also suppressed when the cells used to transfer immunity became engaged in a GVH reaction (Boyse, 1959;Goldstein, Skowron-Cendzrak and Wicher, 1965;Wakefield and Rose, 1968;Lawrence and Simonsen, 1967).…”