Survival of dental implants in patients with oral cancer treated by surgery and radiotherapy: a retrospective study

Abstract

BackgroundThe aim of this retrospective study was to evaluate the survival of dental implants placed after ablative surgery, in patients affected by oral cancer treated with or without radiotherapy.MethodsWe collected data for 34 subjects (22 females, 12 males; mean age: 51 ± 19) with malignant oral tumors who had been treated with ablative surgery and received dental implant rehabilitation between 2007 and 2012. Postoperative radiation therapy (less than 50 Gy) was delivered before implant placement in 12 patients. A total of 144 titanium implants were placed, at a minimum interval of 12 months, in irradiated and non-irradiated residual bone.ResultsImplant loss was dependent on the position and location of the implants (P = 0.05–0.1). Moreover, implant survival was dependent on whether the patient had received radiotherapy. This result was highly statistically significant (P < 0.01). Whether the implant was loaded is another highly significant (P < 0.01) factor determining survival. We observed significantly better outcomes when the implant was not loaded until at least 6 months after placement.ConclusionsAlthough the retrospective design of this study could be affected by selection and information biases, we conclude that a delayed loading protocol will give the best chance of implant osseointegration, stability and, ultimately, effective dental rehabilitation.

Effect of advanced age and/or systemic medical conditions on dental implant survival: A systematic review and meta‐analysis

“…Seventeen studies were identified which met the inclusion and exclusion criteria (Table ) (Arcuri, Fridrich, Funk, Tabor & LaVelle, ; Bodard et al., ; Buddula et al., ; Cuesta‐Gil et al., ; Eckert, Desjardins, Keller & Tolman, ; Ernst et al., ; Fenlon et al., ; Gander, Studer, Studer, Gratz & Bredell, ; Heberer, Kilic, Hossamo, Raguse & Nelson, ; Hessling et al., ; Korfage et al., ; Linsen, Martini & Stark, ; Mancha de la Plata et al., ; Mericske‐Stern, Perren & Raveh, ; Pompa et al., ; Sammartino, Marenzi, Cioffi, Tete & Mortellaro, ). Most of the studies reported on implants placed after radiotherapy (Arcuri et al., ; Bodard et al., ; Ernst et al., ; Gander et al., ; Heberer et al., ; Hessling et al., ; Korfage et al., ; Linsen et al., ; Mancha de la Plata et al., ; Pompa et al., ; Sammartino et al., ). Only two studies also included patients with implants placed prior to radiotherapy (Hessling et al., ; Mericske‐Stern et al., ).…”

Survival/Success of Dental Implants with Acid-Etched Surfaces: A Retrospective Evaluation After 8 to 10 Years

“…The radiotherapy performed in patients with cancer may cause progressive fibrosis of blood vessels and soft tissues, leading to a decrease in vascularization and healing capacity. This decrease in vascularization may be related to the lower survival rate of implants placed in patients irradiated in head and neck (14,15). Likewise, the vasoconstriction caused by smoking seems to have a strong relationship with peri-implant bone resorption in smokers (16).…”

Artigo plagiado.

“…Muitos pacientes com deformidades oculopalpebrais recebem radioterapia após uma cirurgia de câncer. Os protocolos de radioterapia para tumores de cabeça e pescoço geralmente consistem em irradiação nos campos cervicofaciais, com doses totais entre 50 e 70 Gy 19 . Normalmente, essa dose de radiação é administrada em frações de 2 Gy por dia, durante 5 dias por semana, durante um período de 5 a 7 semanas 19 .…”