Survival of Diabetics with Proteinuria

Onset and Progress of Diabetic Glomerulosclerosis

“…Mann and his colleagues (1949) reported that the average survival period in juvenile diabetics was only 6.4 years since the onset of nephrotic syndrome, whereas our own result agrees fairly well with that of Hatch and his colleagues (1961), who showed that most cases of diffuse and mixed renal lesion had died in about two years after confirmed diagnosis. In contrast to Caird's (1961) result that the expected survival rates of diabetics with proteinuria were not so bad as had generally been accepted, our data clearly indicate that diabetic glomerulosclerosis can advance almost steadily and that especially in juvenile diabetics it is sometimes impossible to arrest the progress by medical treatments. It appears necessary in the future to introduce surgical treatments such as renal transplantation or pituitary operation into the clinical practice.…”

Diabetic Angiopathy

“…Although urcemia is now the major cause of death in young diabetics with generalized angiopathy, the prognosis for older groups of patients may not be so uniformly poor as has been assumed (Caird, 1961). In this study by Caird, 65% of 134 diabetics with proteinuria survived for five years and 28% for ten years, but over half of his total group was aged over so years.…”

“…The prognosis for sight has been critically reviewed by Caird andGarrett (1962, 1963), who point out that of a large group of retinopathic diabetics followed for five years only 14 · 5% of those with initially " good " vision had become blind, as compared with those having some initial impairment, of whom so% had become blind. Visual acuity is relatively unimpaired by microaneurysms alone (Lundback, 1953), but it probably depends upon progressive damage to the neural elements of the retina.…”

Responding to the challenge of diabetic nephropathy: the historic evolution of detection, prevention and management

“…In the pre-dialysis era, follow-up studies in the UK 14 and Denmark 15 of 134 and 101 type 1 diabetic patients, respectively, demonstrated survival rates of 50% and approximately 40% at 10 years. Studies from the Joslin clinic over the same period showed an approximately 17-fold increase in renal and cardiovascular death over the non-diabetic population.…”