Survival of drug-resistant metastatic papillary thyroid cancer under drug treated conditions via upregulation of sarco/endoplasmic reticulum calcium ATPase 1
Seok-Mo Kim,
Keunwan Park,
Hyeok Jun Yun
et al.
Abstract:Background: Papillary thyroid cancer (PTC) is a general thyroid cancer subtype, however, PTC may develop metastasize or become recurrent via anti-cancer drug resistance, rendering it practically incurable. Therefore, effective and reliable clinical approaches are urgently required.
Methods: In this study, we demonstrated the coordinated upregulation of SERCA1 in metastatic PTC under anti-cancer drug treated conditions. SERCA1, in turn, is transcriptionally upregulated by CaMK2α via nuclear translocated NFκB. w… Show more
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