Survival of glaucoma patients

Egge, K.; Zahl, Per‐Henrik

doi:10.1034/j.1600-0420.1999.770407.x

Cited by 33 publications

(30 citation statements)

References 9 publications

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“…However, it has been postulated that an association could possibly arise as an adverse complication of OAG treatment or due to a common overlapping pathogenic pathway. 13 Acetazolamide treatment for OAG is known to be associated with an increased risk of mortality, 14 and the systemic effects of other IOP-modulating medications are well established. 13 Lee et al 7 identified a significant relationship between topical b-blocker use and cardiovascular mortality.…”

Section: Resultsmentioning

confidence: 99%

Mortality in primary open-angle glaucoma: ‘two cupped discs and a funeral’

Hewitt

Sanfilippo

Ring

et al. 2009

Eye

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Purpose The aim of this study was to investigate the causes of mortality in individuals with open-angle glaucoma (OAG). Methods All-cause mortality data from the Registry of Births, Deaths and Marriages for the Australian state of Tasmania, for all people who were at least 40 years of age at the time of death, were classified using International Classification of Diseases-10 guidelines. This information was cross-referenced to identify participants in the Glaucoma Inheritance Study in Tasmania (GIST) who had died. Contingency tables were used for crude analysis and then models were constructed, adjusting for age at death as well as gender. Results Between 1996 and 2005, a total of 33 879 deaths were recorded. Data were unavailable for 4868 (14.4%) people. The mean age at death for the study sample was 78.4 ± 11.5 (range 41-109) years. Of those cases known to have OAG by their participation in GIST (n ¼ 2409), full mortality data were available for 741 (92.0%). Following adjustment for the age at death and male gender, the odds ratio for death due to ischaemic heart disease in people with OAG compared to the general population not known to have OAG was significant (OR ¼ 1.30, 95% CI: 1.08-1.56; P ¼ 0.006). Crude analysis revealed that there were significantly fewer people with OAG who died due to metastatic cancer (Po0.001); however, this did not remain significant following adjustment for age and gender. Conclusion The pathoaetiological relationship between OAG and ischaemic heart disease is unclear and requires further investigation. Increased awareness of the association between cardiovascular disease and OAG is warranted.

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Section: Resultsmentioning

confidence: 99%

Mortality in primary open-angle glaucoma: ‘two cupped discs and a funeral’

Hewitt

Sanfilippo

Ring

et al. 2009

Eye

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“…3,[5][6][7] One study 5 showed the lowest survival rate to be among males using acetazolamide. In our study, of the 23 pairs of patients who could be considered for visual field progression, the male/female mix in each group was identical (Table 5).…”

Section: Discussionmentioning

confidence: 99%

“…1 Even on treatment, an estimated 9% of the patients will become bilaterally blind after 20 years of treatment. 2 Some studies have considered glaucoma and its relationship to shortened survival, [3][4][5][6][7] Others have considered the effects of systemic disease on glaucomatous progression. 8,9 These studies, however, do not consider poor life expectancy as a factor in glaucomatous progression.…”

Section: Introductionmentioning

confidence: 99%

Is poor life expectancy a predictive factor in the progression of primary open angle glaucoma?

Tattersall

Vernon

Negi

2004

Eye

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Aim To investigate the disease progression and final visual outcome of glaucoma patients with poor life expectancy, compared to matched patients with a longer life expectancy. Method Visual fields at diagnosis and at the last ophthalmic appointment before death were analysed for glaucoma patients referred between 1991 and 1995, and deceased before the end of 2001. These patients were matched to the patients living beyond 2001. Functional vision was also assessed, and classified as better than the NHS partial sighted criteria. Results A total of 61 deceased patients were identified, resulting in 40 matched pairs. In all, 6.5% of the patients with poor life expectancy progressed from functional vision to beyond partial sighted criteria, and none of the matched patients progressed to this extent. At final assessment an association between poor life expectancy and progression beyond functional vision was found existing (P ¼ 0.02), with a lesser association at diagnosis (P ¼ 0.06). Visual field scores of the matched pairs who had test results available for both initial and final assessment (n ¼ 23 pairs) showed no statistically significant difference between the two groups at diagnosis (P ¼ 0.52); However, a significant difference at final the assessment did exist (P ¼ 0.042). No difference between the initial (off medication) intraocular pressures (IOPs) was found (P ¼ 0.82). At the final assessment a significant difference existed (P ¼ 0.025), with the surviving group having a higher final mean pressure (15.9 mmHg, SD 2.8, vs 18.3 mmHg, SD 4.9). Conclusion Patients with poor life expectancy progressed more than the matched surviving patients, when measured from an initially similar position, despite better IOP control.

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“…In the past few years the possibility of a reduced survival rate among glaucoma patients has indeed been reported by no less than three quite different studies [10,19,24]. Other recent studies do not confirm, but cannot exclude, such a possibility [5,23,39]; therefore, "no clear relationship has emerged from research on this issue" [26].…”

Section: Introductionmentioning

confidence: 96%