Survival of Lupus Nephritis Patients After Renal Transplantation In Malaga

Fuentes, Laura; Hernandez, Dena G.; Ruiz, Phillip; Blanca, L.; López, Verónica; Sola, E.; Gutiérrez, Cristina; Cabello, M.D. Navarro; Burgos, D.; González‐Molina, Miguel; Nebro, Antonio Fernández

doi:10.1016/j.transproceed.2012.07.063

Cited by 8 publications

(4 citation statements)

References 3 publications

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“…Fuentes et al . 30 reported vascular thrombosis as a cause of renal graft loss in 16.3% of patients with SLE submitted to transplantation, and Stone et al . 31 reported clinical events associated with aPLs in 96 patients with SLE submitted to renal transplantation.…”

Section: Discussionmentioning

confidence: 99%

Outcome and Prognosis of Patients With Lupus Nephritis Submitted to Renal Transplantation

Albuquerque

Salles

Tajra

et al. 2019

Sci Rep

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This stydy aimed to evaluate the epidemiological and clinical profile and outcome of patients with lupus nephritis (LN) submitted to renal transplantation. Retrospective cohort study based on the records of 35 LN patients submitted to renal transplantation at a single center in Brazil between July 1996 and May 2016. The Kaplan-Meier method was used to estimate 6-month, 1-year and 5-year graft survival. The sample included 38 transplantations (3 of which retransplantations). The mean age at the time of SLE diagnosis was 23.7 ± 9.0 years. Most patients were female (94.7%) and 68.4% were non-Caucasian. Twenty-two (57.9%) underwent renal biopsy prior to transplantation. The mean time from SLE diagnosis to transplantation was 10.3 ± 6.4 years. The mean pre-transplantation dialysis time was 3.8 ± 3.7 years. The grafts came from living related (n = 11) or deceased (n = 27) donors. Three (7.9%) patients experienced acute rejection in the first year. Graft and patient survival rates were, respectively, 97.1% and 100% at 6 months, 84.9% and 96.9% at 1 year, and 76.3% and 92.5% at 5 years. One (2.6%) patient had SLE recurrence. Venous thrombosis ( p = 0.017) and antiphospholipid syndrome (APS) ( p = 0.036) were more prevalent in patients with graft loss. In our cohort of LN patients submitted to renal transplantation, the 5-year survival rate was high, and APS was an important predictor of poor renal outcome (graft loss).

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Section: Discussionmentioning

confidence: 99%

Outcome and Prognosis of Patients With Lupus Nephritis Submitted to Renal Transplantation

Albuquerque

Salles

Tajra

et al. 2019

Sci Rep

View full text Add to dashboard Cite

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“…Moroni et al 6 reported thrombotic complications in 26% of renal transplantation patients with SLE. Fuentes et al 19 reported vascular thrombosis as the cause of graft loss in 16.3% of the patients with SLE. Thrombosis may occur at any time before or after the transplantation.…”

Section: Discussionmentioning

confidence: 99%

Outcomes in renal transplant recipients with lupus nephritis: experience at a single center

et al. 2014

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Background: The long-term prognosis of renal transplant recipients with systemic lupus erythematosus is still controversial. The outcome of these patients depends on the population studied, race/ethnicity, socioeconomic conditions, donor-related factors and recurrent lupus nephritis (LN), among other factors. Objective: This study was conducted to evaluate kidney transplantation outcomes for adult Brazilian patients with LN at a single center. Subjects and method: The archival records of all patients with LN who had received a kidney transplant at Santa Casa of Sao Paulo Hospítal were reviewed. Kaplan-Meier method was used to determine the survival rate. Results: We identified 18 patients with LN subjected to 22 kidney transplants during the 20-year interval. Two patients received three renal grafts. The majority of the patients were female, with 33.7 ± 10 years at the time of the transplantation, and half of them were African descendants or mixed. Sixteen transplants were performed from deceased donors and six from living-related donors. The patient survival rate was 90%, and graft survival was 68% at 10 years. Chronic allograft nephropathy was the major cause of graft loss. Two patients developed extra-renal manifestations of lupus. There was no clinical or histological evidence of recurrent LN. Conclusion: Renal transplantation is a method which can provide a long-term survival for patients with SLE and end-stage renal disease.

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“…Ponticelli et al , in a study on 32 LN kidney transplant patients, reported a 96% patient survival after ten years vs 91% in controls and 77% graft survival in LN vs 78% in controls 11 . Fuentes et al performed a study on 94 LN kidney transplant patients and a group of DN-ESRD, showing a similar curve of graft survival in five years for both groups 32 . Nonetheless, other studies show worse results in the graft survival of LN patients 33 , 34 .…”

Section: Discussionmentioning

confidence: 86%

Clinical outcomes of kidney transplants on patients with end-stage renal disease secondary to lupus nephritis, polycystic kidney disease and diabetic nephropathy

et al. 2016

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Background: Patients with lupus nephritis could progress to end-stage renal disease (10-22%); hence, kidney transplants should be considered as the treatment of choice for these patients. Objective: To evaluate the clinical outcomes after kidney transplants in patients with chronic kidney diseases secondary to lupus nephritis, polycystic kidney disease and diabetes nephropathy at Pablo Tobon Uribe Hospital. Methods: A descriptive and retrospective study performed at one kidney transplant center between 2005 and 2013. Results: A total of 136 patients, 27 with lupus nephritis (19.9%), 31 with polycystic kidney disease (22.8%) and 78 with diabetes nephropathy (57.4%), were included in the study. The graft survivals after one, three and five years were 96.3%, 82.5% and 82.5% for lupus nephritis; 90%, 86% and 76.5% for polycystic kidney disease and 91.7%, 80.3% and 67.9% for diabetes nephropathy, respectively, with no significant differences (p= 0.488); the rate of lupus nephritis recurrence was 0.94%/person-year. The etiology of lupus vs diabetes vs polycystic disease was not a risk factor for a decreased time of graft survival (Hazard ratio: 1.43; 95% CI: 0.52-3.93). Conclusion: Kidney transplant patients with end stage renal disease secondary to lupus nephritis has similar graft and patient survival success rates to patients with other kidney diseases. The complication rate and risk of recurrence for lupus nephritis are low. Kidney transplants should be considered as the treatment of choice for patients with end stage renal disease secondary to lupus nephritis.

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Survival of Lupus Nephritis Patients After Renal Transplantation In Malaga

Cited by 8 publications

References 3 publications

Outcome and Prognosis of Patients With Lupus Nephritis Submitted to Renal Transplantation

Outcome and Prognosis of Patients With Lupus Nephritis Submitted to Renal Transplantation

Outcomes in renal transplant recipients with lupus nephritis: experience at a single center

Clinical outcomes of kidney transplants on patients with end-stage renal disease secondary to lupus nephritis, polycystic kidney disease and diabetic nephropathy

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