Survival of mature T cells depends on signaling through HOIP

Okamura, Kazumi; Kitamura, Akiko; Sasaki, Yoshiyuki; Chung, Doo Hyun; Kubo, Shoji; Iwaï, Kazuhiro; Yasutomo, Koji

doi:10.1038/srep36135

Cited by 18 publications

(12 citation statements)

References 38 publications

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“…Alternative approaches would be needed to capture changes in subpopulation ubiquitylation. These data could be further expanded through use of reagents to identify linear polyubiquitin chains, which are known to have roles in T cell development and homeostasis [45][46][47] but cannot be detected by di-glycine remnant proteomics.…”

Section: Discussionmentioning

confidence: 99%

Integrative proteomics reveals an increase in non-degradative ubiquitylation in activated CD4+ T cells

et al. 2019

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Despite gathering evidence that ubiquitylation can direct non-degradative outcomes, most investigations of ubiquitylation in T cells have focused on degradation. Here, we integrated proteomic and transcriptomic datasets from primary mouse CD4 + T cells to establish a framework for predicting degradative or non-degradative outcomes of ubiquitylation. Di-glycine remnant profiling was used to reveal ubiquitylated proteins, which in combination with whole-cell proteomic and transcriptomic data allowed prediction of protein degradation. Analysis of ubiquitylated proteins identified by di-glycine remnant profiling indicated that activation of CD4 + T cells led to an increase in non-degradative ubiquitylation. This correlated with an increase in non-proteasome-targeted K29, K33 and K63 polyubiquitin chains. This study revealed over 1,200 proteins that were ubiquitylated in primary mouse CD4 + T cells and highlighted the relevance of non-proteasomally targeted ubiquitin chains in T cell signaling. Engagement of the T cell antigen receptor (TCR) and the costimulatory receptor CD28 initiates proliferation and effector T cell differentiation. Altering the abundance-via Reprints and permissions information is available at www.nature.com/reprints.

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Section: Discussionmentioning

confidence: 99%

Integrative proteomics reveals an increase in non-degradative ubiquitylation in activated CD4+ T cells

et al. 2019

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“…We and others showed that LUBAC plays a role in activating the canonical NF-kB pathway and inhibiting TNF-a-induced cell death (12)(13)(14)(15). The role of LUBAC during development and function of B and T lymphocytes has also been dissected (16,(27)(28)(29)(30). In B cells, LUBAC plays crucial roles in TD and TI-II Ab responses by controlling CD40and TACI-mediated activation of the canonical NF-kB and ERK pathways, respectively; it also regulates B1 cell development (16).…”

Section: Discussionmentioning

confidence: 99%

Crucial Role of Linear Ubiquitin Chain Assembly Complex–Mediated Inhibition of Programmed Cell Death in TLR4-Mediated B Cell Responses and B1b Cell Development

Sasaki

Iwaï

2018

The Journal of Immunology

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Linear ubiquitin chain assembly complex (LUBAC)-mediated linear polyubiquitin plays crucial roles in thymus-dependent and -independent type II Ab responses and B1 cell development. In this study, we analyzed the role of LUBAC in TLR-mediated B cell responses. A mouse strain in which LUBAC activity was ablated specifically in B cells (B-HOIP mice) showed defective Ab responses to a type I thymus-independent Ag, NP-LPS. B cells from B-HOIP mice (HOIP B cells) underwent massive cell death in response to stimulation of TLR4, but not TLR9. TLR4 stimulation induced caspase-8 activation in HOIP B cells; this phenomenon, as well as TLR4-induced cell death, was suppressed by ablation of TRIF, a signal inducer specific for TLR4. In addition, LPS-induced survival, proliferation, and differentiation into Ab-producing cells of HOIP B cells were substantially restored by inhibition of caspases together with RIP3 deletion, but not by RIP3 deletion alone, suggesting that LPS stimulation kills HOIP B cells by apoptosis elicited via the TRIF pathway. Further examination of the roles of cell death pathways in B-HOIP mice revealed that deletion of RIP3 increased the number of B1 cells, particularly B1b cells, in B-HOIP mice, indicating that B1b cell homeostasis is controlled via LUBAC-mediated suppression of necroptosis. Taken together, the data show that LUBAC regulates TLR4-mediated B cell responses and B1b cell development and/or maintenance by inhibiting programmed cell death.

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“…At ambient temperatures it orders in inverted cubic spinel ferrite with the tetrahedral (A) site occupied by Fe 3+ ions and with Fe 2+ and Fe 3+ ions coexisting at the same octahedral (B) site 26 . Magnetite undergoes a first-order transition below 120 K where the resistivity increases by two orders of magnitude and the structural distortions from cubic symmetry occur 27,28 . It is suggested that this transition is driven by a charge ordering of Fe 2+ and Fe 3+ ions 29 .…”

Section: Soft Ferrimagnetic Fe3o4mentioning

confidence: 99%

Local magnetic anisotropy by polarized neutron powder diffraction: Application of magnetically induced preferred crystallite orientation

Kibalin

Gukasov

2019

Phys. Rev. Research

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Polarized neutron diffraction allows to determine the local susceptibility tensor on the magnetic site both in single crystals and powders. It is widely used in the studies of single crystals, but it is still hardly applicable to a number of highly interesting powder materials, like molecular magnets or nanoscale systems because of the low luminosity of existing instruments and the absence of an appropriate data analysis software. We show that these difficulties can be overcome by using a large area detector in combination with the two-dimensional Rietveld method and powder samples with magnetically induced preferred crystallite orientation. This is demonstrated by revisiting two test powder compounds, namely, low anisotropy (soft) ferrimagnetic compound Fe3O4 and spin-ice compound Ho2Ti2O7 with high local anisotropy. The values of magnetic moments in Fe3O4 and the susceptibility tensors of Ho2Ti2O7 at various temperatures and fields were found in perfect agreement with these found earlier in single crystal experiments. The magnetically induced preferred crystallite orientation was used to study the local susceptibility of a single-molecule magnet Co([(CH3)2N]2CS)2Cl2. Hence, the studies of local magnetic anisotropy in powder systems might now become accessible.

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Survival of mature T cells depends on signaling through HOIP

Cited by 18 publications

References 38 publications

Integrative proteomics reveals an increase in non-degradative ubiquitylation in activated CD4+ T cells

Integrative proteomics reveals an increase in non-degradative ubiquitylation in activated CD4+ T cells

Crucial Role of Linear Ubiquitin Chain Assembly Complex–Mediated Inhibition of Programmed Cell Death in TLR4-Mediated B Cell Responses and B1b Cell Development

Local magnetic anisotropy by polarized neutron powder diffraction: Application of magnetically induced preferred crystallite orientation

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