Survival of Patients with Small Cell Lung Cancer in King Abdulaziz University Hospital, Jeddah, Saudi Arabia

Alhejaili, Faris; Al‐Hajeili, Marwan; Bakhsh, Salwa; Banjar, Nujood S; Alghamdi, Wejdan; Alsulami, Atheer F.; Algamdi, Maha

doi:10.7759/cureus.6648

Cited by 2 publications

(2 citation statements)

References 6 publications

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“…Most patients’ overall survival is less than 5 years whom were diagnosed at advanced stage [ 26 ]. Existing treatments extend the survival of part of patients with lung adenocarcinoma, but the overall curative effect is not so good, especially in the advanced cases [ 27 , 28 ]. The shortage of effective prognostic biomarkers to guide therapy is one of the reasons for the poor prognosis [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Construction of the optimization prognostic model based on differentially expressed immune genes of lung adenocarcinoma

Zhai

Zhao

Wang³

et al. 2021

BMC Cancer

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Background Lung adenocarcinoma (LUAD) is the most common pathology subtype of lung cancer. In recent years, immunotherapy, targeted therapy and chemotherapeutics conferred a certain curative effects. However, the effect and prognosis of LUAD patients are different, and the efficacy of existing LUAD risk prediction models is unsatisfactory. Methods The Cancer Genome Atlas (TCGA) LUAD dataset was downloaded. The differentially expressed immune genes (DEIGs) were analyzed with edgeR and DESeq2. The prognostic DEIGs were identified by COX regression. Protein-protein interaction (PPI) network was inferred by STRING using prognostic DEIGs with p value< 0.05. The prognostic model based on DEIGs was established using Lasso regression. Immunohistochemistry was used to assess the expression of FERMT2, FKBP3, SMAD9, GATA2, and ITIH4 in 30 cases of LUAD tissues. Results In total,1654 DEIGs were identified, of which 436 genes were prognostic. Gene functional enrichment analysis indicated that the DEIGs were involved in inflammatory pathways. We constructed 4 models using DEIGs. Finally, model 4, which was constructed using the 436 DEIGs performed the best in prognostic predictions, the receiver operating characteristic curve (ROC) was 0.824 for 3 years, 0.838 for 5 years, 0.834 for 10 years. High levels of FERMT2, FKBP3 and low levels of SMAD9, GATA2, ITIH4 expression are related to the poor overall survival in LUAD (p < 0.05). The prognostic model based on DEIGs reflected infiltration by immune cells. Conclusions In our study, we built an optimal prognostic signature for LUAD using DEIGs and verified the expression of selected genes in LUAD. Our result suggests immune signature can be harnessed to obtain prognostic insights.

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Section: Discussionmentioning

confidence: 99%

Construction of the optimization prognostic model based on differentially expressed immune genes of lung adenocarcinoma

Zhai

Zhao

Wang³

et al. 2021

BMC Cancer

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“…A previous study in Saudi Arabia found that the median duration of survival for patients with small cell lung carcinoma was 6.4 months. 5 Lung cancer is one of the leading causes of death worldwide, and it is ranked as the first cause of death in more than 100 countries around the world. 6 The five-year survival rate of lung cancer is only around 14%, 7 however, when it is diagnosed at early age, the overall survival rate will increase in around 50% of the patients, nevertheless, only small percentage of patients are diagnosed at early stage.…”

Section: Introductionmentioning

confidence: 99%

Public Attitudes Towards Lung Cancer Screening in Saudi Arabia: A Cross-Sectional Study

Dairi¹,

Bahakeem²

2023

JMDH

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Lung cancer is one of the leading causes of death worldwide, and it is ranked as the first cause of death in more than 100 countries around the world. The aim of this study was to explore the knowledge and attitude of the general population in Saudi Arabia toward lung cancer screening. Methods: A cross-sectional study employing an online survey was conducted between November 2021 and February 2022 in Saudi Arabia. This study utilized a previously developed questionnaire instrument. Logistic regression was used to identify predictors of positive attitude toward lung cancer screening. Results: A total of 473 participants were involved in this study. The majority of the study participants (74.6%) reported that they are current smokers. Almost 31.5% of the study participants reported that if lung cancer is detected early, the person's chance of surviving is poor to very poor. The majority of the study participants reported that they would be willing to do tests to diagnose lung cancer if you were invited by the Ministry of Health or their doctor. Males, participants aged (24-34 years), and current smokers were more likely to have positive attitude towards lung cancer screening (p ≤ 0.05). On the other hand, patients aged 46 years and over and those with higher education had less positive attitude towards lung cancer screening (p ≤ 0.05). Conclusion: This is the first study to look into the general public's attitudes toward lung cancer screening in Saudi Arabia. According to our findings, the majority of people believe that early detection of lung cancer can lead to improved results and have a favourable attitude toward lung cancer screening if it is indicated. Thus, incorporating lung cancer screening into the local guidelines in at-risk population is highly recommended and considering the launch of nation-wide lung cancer screening program is advised.

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Survival of Patients with Small Cell Lung Cancer in King Abdulaziz University Hospital, Jeddah, Saudi Arabia

Cited by 2 publications

References 6 publications

Construction of the optimization prognostic model based on differentially expressed immune genes of lung adenocarcinoma

Construction of the optimization prognostic model based on differentially expressed immune genes of lung adenocarcinoma

Public Attitudes Towards Lung Cancer Screening in Saudi Arabia: A Cross-Sectional Study

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