Survival of Patients With Testicular Cancer in Lithuania During 1999–2002

Juška, Agnius; Ulys, Albertas; Kairevičė, Laura; Smailytė, Giedrė; Stankevičius, Edgaras; Jančiauskienė, Rasa; Jievaltas, Mindaugas

doi:10.3390/medicina47010008

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…Our study confirms good overall reproductive health in Lithuania, since the prevalence of hypospadias (25) and cryptorchidism ( 26) is low, and semen quality and sexual hormone parameters are better when compared with Denmark, Sweden and Norway (11). We also have relatively short time to pregnancy (27) and low prevalence of testicular cancer (28,29).…”

Section: Questionssupporting

confidence: 75%

Approaches to the 26–36-year-old Lithuanian Men’s Sexual Function

et al. 2016

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context. In the year 2003-2004 a circumstantial investigation of young men reproductive health parameters was performed in Nordic and Baltic countries, but sexuality remained undetermined.objective. To determine the suitability of the European Male Ageing Study -Sexual Function Questionnaire (EMAS -SFQ) for investigation of sexuality of 26-36 year aged general population and to investigate sexuality of Kaunas participants in the project "The reproductive function of Estonian, Latvian and Lithuanian Young men (2003)(2004))" (KELLY), using EMAS -SFQ.design. Sixty one 26-36 year aged KELLY men were recaptured from the list of participants in a 2003-2004 study and completed EMAS -SFQ. Their anthropometric characteristics, scores of sexuality (22 parameters from EMAS -SFQ, 3 calculated parameters and 2 parameters consisting from answers to the only question -masturbation and erectile function-for each participant) were analysed, in conjunction with anthropometric, sperm quality and hormone levels of 2003-2004 18-25 year old general population.results. Overall sexual functioning and masturbation were higher as compared to all the published data for different age men and different testosterone concentration groups of EMAS study.conclusions. KELLY sexuality results, obtained using EMAS -SFQ, would be considered as referral values for young men in countries with generally good reproductive health.

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Section: Questionssupporting

confidence: 75%

Approaches to the 26–36-year-old Lithuanian Men’s Sexual Function

et al. 2016

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“…For overall survival (OS) of TC patients, Juška Aet al [18] , Mao W et al [19] and Rolevich A et al [20] reported that age at diagnosis was associated with survival among TC patients. Li [21] reported that surgery therapy can improve prognosis.…”

Section: Discussionmentioning

confidence: 99%

A clinical prediction model for testicular cancer prognosis: from the SEER study

Zhao¹

2023

Preprint

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Background: The influencing factors on the prognosis of patients with testicular cancer (TC) remains unclear. We aimed to explore the clinical influencing factors of overall survival (OS) and cancer-specific survival (CSS) of Testicular Cancer (TC) patients and to build the nomograms. Methods: Within the Surveillance, Epidemiology, and End Results (SEER) database, 7718 TC patients diagnosed between 2004 and 2018 were included and their clinical data were assessed. The data were randomly divided into training and validation cohorts in a ratio of 7:3 to construct the prediction models. Prognosis information including 3-, 5-, and 10-year OS and CSS rates were recorded. In this study, the Kaplan-Meier method was used to draw the survival curve and variables with P<0.05 in the univariate Cox proportional hazard regression model were included in the multivariate Cox proportional hazard regression model for analysis. The relative risk of death was described with the hazard ratio (HR) and the 95% confidence interval (CI). The differentiation of the model was evaluated by using ROC and calculating the AUC values at different time points. Based on the data of the prediction set, the Bootstrapping method was adopted, repeated sampling 1000 times, and calibration curves were drawn to evaluate the fit degree of the model. Based on the results of the Cox proportional risk regression model, we constructed and internally validated an applicable nomogram for predicting 3-year, 5-year and 10-year survival in patients with testicular cancer. Results: A total of 7718 patients were included in the prognostic model. In the multivariate Cox regression model, older age at diagnosis, without surgery, regional lymph node involvement (N1, N2, N3 and NX), with chemotherapy and larger tumor size were independent predictors of poor prognosis factors for OS and CSS in TC patients. The C-indexes were 0.75 (95% confidence interval [CI]: 0.72- 0.78) for OS and 0.82 (95% CI: 0.79- 0.85) for CSS, indicating that the prognosis of testicular cancer patients had a good predictive effect. Based on the nomogram, in the verification group, the AUC values of the 3-, 5-, and 10-year OS were 0.799, 0.757; 0.725, and 0.827, 0.823, and 0.825 for 3, 5, and 10- years CSS, respectively. The differences in the OS and CSS between the real observation and the forecast were quite constant according to the calibration curves. The models were validated in the validation cohort, which also demonstrated the models had good reliability for prognostication. Conclusions: Clinical factors including age at diagnosis, surgery conditions, N Stage, chemotherapy conditions and tumor size were good predictors for OS and CSS in TC. Our predictive nomogram may play an important role in predicting 3-, 5-, and 10-year outcomes in patients with TC.

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“…However, in some Baltic countries, the results were poorer, e. g. in Lithuania, it was only 71.2% in the same time--period [17]. Even despite the significant improvement in survival recorded in Estonia, the values of the 5-year relative survival in 2000-2004 are at a relatively low level, 74.5% [18].…”

Section: Tc -Testicular Cancermentioning

confidence: 99%

Recent Trends in Survival of Testicular Cancer Patients – Nation-wide Population Based Study

Ondruš¹,

Ondrušová²,

Suchansky³

2018

Klin Onkol

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Moderate improvement in survival for TC patients in the Slovak Republic is probably influenced by diagnostic and therapeutic progress, including multidisciplinary care and patients concentration in specialized centers. The long-term follow-up of TC survivors can also help to prevent late side effects of the treatment modalities and to detect second malignancies.Key words: testicular cancer - seminoma - non-seminoma - age at diagnosis - survival.

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Survival of Patients With Testicular Cancer in Lithuania During 1999–2002

Cited by 5 publications

References 7 publications

Approaches to the 26–36-year-old Lithuanian Men’s Sexual Function

Approaches to the 26–36-year-old Lithuanian Men’s Sexual Function

A clinical prediction model for testicular cancer prognosis: from the SEER study

Recent Trends in Survival of Testicular Cancer Patients – Nation-wide Population Based Study

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