Survival of primates in LD100 septic shock following steroid/antibiotic therapy

Effectiveness of Steroid/Antibiotic Treatment in Primates Administered LD100 Escherichia coli

“…Results from the present study and our earlier reports in dogs and baboons (1,2,5) suggested that fluid administration, neither prevents nor influences survival of animals in E. coli-induced shock.…”

“…However, this survival rate was lower than that obtained when treatment was initiated earlier (1,2). Surviving animals of the present study developed body surlace ulcerations, refused to eat for several days, and…”

“…Baboons of either sex were divided into two groups and each infused with live F. coli for two hours: the control group (N=8; average weight, 16.8 kg) were given 2.4 (+0.2)x1010 organisms/kg body weight prepared as previously described (1,3,4). The experimental group (N=8; average 10 weight, 17.9 kg) received 2.5 (±0.2)xlO E. coli/kg body weight, the steroid, methylprednisolone sodium succinate (MPSS; The Upjohn Company,…”

Modification by steroids of pulmonary oedema and prostaglandin E2 pharmacokinetics induced by endotoxin in rats

“…The best results are achieved by large doses of steroid given as early as possible (Sprung et al, 1984;Sibbald et al, 1981; see also Hinshaw et al, 1980;Borg et al, 1985b). It is clearly not possible, given the present means of diagnosis of ARDS -abnormalities in chest X-rays or in blood gases -to identify and treat the 'pre-ARDS' patient as early as we can in our experimental study.…”

“…there is considerable experimental evidence that corticosteroids antagonize or prevent lung injury due to endotoxaemia (Al-Kaisi et al, 1977;Hinshaw et al, 1980;Brigham et al, 1981;Schumer, 1981;Borg et al, 1985b), we have also looked at the effects of two synthetic corticosteroids, methylprednisolone and budesonide, on our model of endotoxin-induced lung injury. A preliminary account of some of this work has been given to the British Pharmacological Society (Izumi & Bakhle, 1987).…”