Survival of recipients of cadaveric kidney transplants compared with those receiving dialysis treatment in Australia and New Zealand, 1991-2001

McDonald, S.; Russ, Graeme

doi:10.1093/ndt/17.12.2212

Cited by 157 publications

(111 citation statements)

References 16 publications

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“…The survival benefit of kidney transplantation over dialysis treatment was previously demonstrated in various geographic areas with different health care systems. [1][2][3][4] Our study confirms these results and adds contemporary information from a large European cohort of dialysis patients who were on the waiting list. The relative mortality rate reduction of 55% in our cohort at 18 months after standard-criteria DBD kidney transplantation seems lower than previously reported (68 to 82% at 12 to 18 months after transplantation).…”

Section: Discussionsupporting

confidence: 79%

“…The relative mortality rate reduction of 55% in our cohort at 18 months after standard-criteria DBD kidney transplantation seems lower than previously reported (68 to 82% at 12 to 18 months after transplantation). [1][2][3][4] This difference may be the result of the more rigorous sequential stratification analysis used in this study, because analysis of our data using timedependent Cox regression produced a relative mortality rate reduction of 65% at 18 months after standard-criteria DBD kidney transplantation. Furthermore, the survival benefit of kidney transplantation in the United States extends to kidneys recovered from ECDs.…”

Section: Discussionmentioning

confidence: 99%

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Kidneys from Donors after Cardiac Death Provide Survival Benefit

Snoeijs¹,

Schaubel

Hené

et al. 2010

Journal of the American Society of Nephrology

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The continuing shortage of kidneys for transplantation requires major efforts to expand the donor pool. Donation after cardiac death (DCD) increases the number of available kidneys, but it is unknown whether patients who receive a DCD kidney live longer than patients who remain on dialysis and wait for a conventional kidney from a brain-dead donor (DBD). This observational cohort study included all 2575 patients who were registered on the Dutch waiting list for a first kidney transplant between January 1, 1999, and December 31, 2004. From listing until the earliest of death, living-donor kidney transplantation, or December 31, 2005, 459 patients received a DCD transplant and 680 patients received a DBD transplant. Graft failure during the first 3 months after transplantation was twice as likely for DCD kidneys than DBD kidneys (12 versus 6.3%; P ϭ 0.001). Standard-criteria DCD transplantation associated with a 56% reduced risk for mortality (hazard ratio 0.44; 95% confidence interval 0.24 to 0.80) compared with continuing on dialysis and awaiting a standard-criteria DBD kidney. This reduction in mortality translates into 2.4-month additional expected lifetime during the first 4 years after transplantation for recipients of DCD kidneys compared with patients who await a DBD kidney. In summary, standard-criteria DCD kidney transplantation associates with increased survival of patients who have ESRD and are on the transplant waiting list.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Kidneys from Donors after Cardiac Death Provide Survival Benefit

Snoeijs¹,

Schaubel

Hené

et al. 2010

Journal of the American Society of Nephrology

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“…In Australia and New Zealand, the population mix differs, with indigenous Australians, Mäori and Pacific Islanders contributing to the non-white population. These racial groups may have reduced incidence of melanoma, colon, breast and prostate cancers compared to the general population (34), and within the transplanted population also have reduced graft and overall survival, both of which may contribute to our findings (35). That race behaves as a proxy for unmeasured socio-economic or environmental factors that may confound cancer risk is also possible, but our ability to investigate these with available data was limited.…”

Section: Cancer Risk After Kidney Transplantationmentioning

confidence: 93%

Identifying High Risk Groups and Quantifying Absolute Risk of Cancer After Kidney Transplantation: A Cohort Study of 15 183 Recipients

Webster

Craig

Simpson

et al. 2007

American Journal of Transplantation

266

146

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“…In case of the dialysis group, follow-up began six months after initiation of dialysis treatment, to account for acute treatment-related mortality (Ansell et al, 2010), and lasted until death, transplantation, recovery of renal function, loss to follow-up, or censoring at 1 January 2008 or 2009. In case of the patients with a functioning transplant, follow-up began six months after transplantation, to account for acute surgeryrelated mortality (McDonald & Russ, 2002;Meier-Kriesche & Schold, 2005), and lasted until death, transfer to dialysis due to transplant failure, loss to follow-up, or censoring at 1 January 2008 or 2009. For both treatment groups, per five-year age group, the number of deaths was divided by the years of followup, yielding the age-specific mortality rates.…”

Section: Methodsmentioning

confidence: 99%

Senescence rates in patients with end‐stage renal disease: a critical appraisal of the Gompertz model

et al. 2010

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SummaryThe most frequently used model to describe the exponential increase in mortality rate over age is the Gompertz equation. Logarithmically transformed, the equation conforms to a straight line, of which the slope has been interpreted as the rate of senescence. Earlier, we proposed the derivative function of the Gompertz equation as a superior descriptor of senescence rate. Here, we tested both measures of the rate of senescence in a population of patients with end-stage renal disease. It is clinical dogma that patients on dialysis experience accelerated senescence, whereas those with a functional kidney transplant have mortality rates comparable to the general population. Therefore, we calculated the age-specific mortality rates for European patients on dialysis (n = 274 221; follow-up = 594 767 person-years), for European patients with a functioning kidney transplant (n = 61 286; followup = 345 024 person-years), and for the general European population. We found higher mortality rates, but a smaller slope of logarithmic mortality curve for patients on dialysis compared with both patients with a functioning kidney transplant and the general population (P < 0.001). A classical interpretation of the Gompertz model would imply that the rate of senescence in patients on dialysis is lower than in patients with a functioning transplant and lower than in the general population. In contrast, the derivative function of the Gompertz equation yielded the highest senescence rates for patients on dialysis, whereas the rate was similar in patients with a functioning transplant and the general population. We conclude that the rate of senescence is better described by the derivative function of the Gompertz equation.

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Survival of recipients of cadaveric kidney transplants compared with those receiving dialysis treatment in Australia and New Zealand, 1991-2001

Abstract: As well as improved quality of life, cadaveric renal transplantation in Australia and New Zealand is associated with a survival advantage compared with those remaining on the waiting list.

Cited by 157 publications

References 16 publications

Kidneys from Donors after Cardiac Death Provide Survival Benefit

Kidneys from Donors after Cardiac Death Provide Survival Benefit

Identifying High Risk Groups and Quantifying Absolute Risk of Cancer After Kidney Transplantation: A Cohort Study of 15 183 Recipients

Senescence rates in patients with end‐stage renal disease: a critical appraisal of the Gompertz model

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