Survival of Skin Homografts in Adult Mice After Combined Thymectomy-Splenectomy and Steroid Therapy.

Current concepts of the immunological function of the thymus.

“…A combination of steroid therapy, thymectomy, and splenectomy was ineffective in suppressing homograft rejection and humoral antibody formation in adult mice but a slight delay in second-set graft rejection was reported (723). Thymectomy in adults did not potentiate the immunosuppressive action of melphalan (370) although an additive effect was reported with other drugs (I 52).…”

Human Transferrins C and D 1 : Chemical Difference in a Peptide

“…Adult thymectomy prior to hydrocortisone treatment in mice (20) or sublethal irradiation in rats (8) fails to augment skin allograft survival beyond that seen in unthymectomized animals. Neither treatment alone induces prolongation of skin allograft survival comparable to that achieved with antiserum to lymphocytes alone.…”

Skin Allograft Survival in Calves

“…The results of such efforts have been conflicting. [3][4][5][6][7][8][9][10] We decided to investigate the influence of extracorporeal irradiation of blood (ECIB) and thymectomy on skin allograft survival in calves and to compare these results to those obtained with ECIB alone.11 It has been shown that ECIB is a safe and effective means of producing lymphocytopenia, de¬ pleting lymphocytes from the lymphoid organs, and of moder¬ ately prolonging the survival of skin allografts in calves.11"13 In or¬ der to study the influence of time elapsed between thymectomy and allogeneic challenge,814 ECIB and skin allografting was carried out at various times following thymecto¬ my.…”