Survival of the Upper-Urothelial-Cancer Patients from the
Balkan Nephropathy Endemic and Nonendemic Areas

Janković, Slavenka; Marinković, Jelena; Radovanović, Zoran

doi:10.1159/000473396

Cited by 11 publications

(8 citation statements)

References 3 publications

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“…Out of all patients, UUT were not categorized in 14 cases, a fact that could be potentially important for the total distribution of grades. A review of the literature revealed similar results, but there were also quite opposite opinions [6][7][8][9][10][11] . The tumor grade is defined as independent risk factor in a univariate analysis that significantly affects the survival of patients.…”

Section: Discussionmentioning

confidence: 96%

Upper Urothelial Tumors in Emigrants from Balkan Endemic Nephropathy Areas in Serbia

Nikolić¹,

Djokic²,

Ignjatović³

et al. 2006

Urol Int

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Aim: The aim of the study was to investigate upper urothelial tumors (UUT) in emigrants from Balkan endemic nephropathy (BEN) areas in Serbia and compare them with UUT from both endemic and nonendemic areas. Materials and Methods: A total of 1,121 patients from the state cancer database, between 1960 and 1998, were investigated. Sixty of them were emigrants from BEN areas. Results: UUT in emigrants from BEN areas occurred after 21.7 ± 9.9 years (median 20) spent in a rural environment. The time spent outside of the BEN regions was 33.2 ± 12.8 years (median 31, range 10–72). Age at surgery was 55 years (range 31–89). In emigrants from BEN areas, there was a significant association of other diseases with UUT: renal failure in 63%, bladder tumors in 23.3% and bilateralism in 6.7% of the patients. Bilateralism was statistically more frequent in emigrants from BEN areas (p = 0.04), as were low-grade tumors (p = 0.03). There was no statistical difference in tumor stage between patients from BEN areas and from outside of them. Relatives of the emigrants from BEN areas were also affected by BEN, UUT and both of them (33%). Conclusions: It is concluded that hereditary as well as environmental factors are important for the expression and evolution of the disease. An early period of life spent in the endemic region seems important for the later development of UUT in emigrants from BEN regions. Different time spans spent in the endemic region have no effect on the age of appearance of UUT.

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Section: Discussionmentioning

confidence: 96%

Upper Urothelial Tumors in Emigrants from Balkan Endemic Nephropathy Areas in Serbia

Nikolić¹,

Djokic²,

Ignjatović³

et al. 2006

Urol Int

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“…Bladder Transitional Cell Carcinoma (TCC) usually appears within fi ve years. Some patients develop pelvis pain and bone metastases (9). The link between BEN and UTT can be explained by insult from an environmental contaminant (10).…”

mentioning

confidence: 99%

Ochratoxin A and Aristolochic Acid Involvement in Nephropathies and Associated Urothelial Tract Tumours

Pfohl‐Leszkowicz

2009

Archives of Industrial Hygiene and Toxicology

107

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This review addresses the unresolved aetiology of several nephropathies and associated upper tract tumours diagnosed all over the world, but especially in the Balkan regions. Studies conducted over the last 35 years point to mycotoxins, mainly ochratoxin A (OTA) as the main culprit. Recent theories however have implicated aristolochic acids (AA). The aim of this review is to put forward arguments in favour of the mycotoxin theory and to show the incoherence of the AA theory. It discusses the differences between the epidemiology of Balkan endemic nephropathy (BEN) and aristolochic acid nephropathy (AAN); OTA and AA carcinogenicity; clinical and pathological effects induced by OTA and AA; sources of OTA contamination (food, air, drinking water); OTA-and AA-DNA adduct formation; the role of genetic polymorphisms ; and the risk for young children.

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“…The patients with BN developed 14 (51.9%) of all urinary tract cancers. The most frequent were the upper urothelial tumors [7], Four patients had malignant tumors of the kidney, and 3 bladder cancers.…”

Section: Resultsmentioning

confidence: 99%

“…An especially high incidence of upper uro thelial tumors (UUT) was observed in patients with Bal kan nephropathy (BN) [6][7][8],…”

Section: Introductionmentioning

confidence: 99%

Malignant Tumors in Hemodialysis Patients

1996

Nephron

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We reviewed the incidence of malignant tumors among 923 patients with chronic renal failure, treated with hemodialysis (HD) in seven dialysis centers in Serbia between January 1983 and July 1993. Neoplasms were diagnosed in 45 cases (4.9%). The mean age of the cancer patients was 58.7 years. Eighteen cases (40.0%) were diagnosed in the first year after starting HD treatment and 21 (46.7%) cases were detected less than 5 years after induction of HD treatment. Most of the cancer patients (60.0%), especially the patients with Balkan endemic nephropathy (31.1 %), developed cancer of the urinary tract. We concluded that HD patients have a several times greater risk of developing malignant tumors than the general population.

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Survival of the Upper-Urothelial-Cancer Patients from the Balkan Nephropathy Endemic and Nonendemic Areas

Cited by 11 publications

References 3 publications

Upper Urothelial Tumors in Emigrants from Balkan Endemic Nephropathy Areas in Serbia

Upper Urothelial Tumors in Emigrants from Balkan Endemic Nephropathy Areas in Serbia

Ochratoxin A and Aristolochic Acid Involvement in Nephropathies and Associated Urothelial Tract Tumours

Malignant Tumors in Hemodialysis Patients

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