“…However, these landmarks may be missing when facing significant bone defects. This is notably the case when performing a distal femoral knee megaprostheses after resection of a primary malignant bone tumor [5,6,22] or for the treatment of bone metastasis, comminuted articular fracture, nonunions, failed knee replacements, and periprosthetic fractures [8,9,11,12,18,27,30,33].…”