Survival outcome of malignant minor salivary tumors in Pakistani population

Iqbal, Hassan; Bhatti, Abu Bakar Hafeez; Hussain, Raza; Jamshed, Arif

doi:10.4103/2278-330x.136792

Cited by 4 publications

(5 citation statements)

References 23 publications

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“…Antti Mäkitie and Leif Bäck have contributed equally ACC is denoted as the second most common malignancy [2]. Some nationwide studies from Finland, Denmark, and Pakistan, however, have reported that the most common salivary gland cancer in those countries is ACC [3][4][5].…”

Section: Karoliina Hirvonen Shared First Authorshipmentioning

confidence: 99%

Early stage minor salivary gland adenoid cystic carcinoma has favourable prognosis

et al. 2017

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The purpose of the study was to evaluate the long-term outcome of minor salivary and mucous gland (MiSG) adenoid cystic carcinoma (ACC) of the head and neck and to compare the results with earlier reports including our recently published series on major salivary gland (MaSG) ACC. The study comprised 68 MiSG ACCs operated during 1974-2012 at the Helsinki University Hospital, Helsinki, Finland. Medical records and histological samples were reviewed. Our previously published cohort comprising 54 MaSG ACCs during the years from 1974 to 2009 was used for comparison. The most common locations were the oral cavity and sinonasal cavities. Most patients presented stages IV (33.8%) and I (23.5%) disease. Primary treatment with curative intent, mainly surgery, was offered for 64 patients. Thirty-three (51.6%) of these patients developed a disease recurrence and 22 (66.7%) patients in less than 5 years. The difference in the length of recurrence-free time (<5 vs. >5 years) had an impact on OS and DSS (p < 0.001) showing worse prognosis for the earlier recurring group. T classes 2-4 (p = 0.005, p < 0.001, and p = 0.001, respectively) and stages II-IV (p = 0.019, p < 0.001, and p = 0.002, respectively) were associated with worse OS, DSS, and DFS. MiSG ACC had a similar long-term survival compared to MaSG ACC. Patients with stage I MiSG ACC seem to carry a favourable prognosis compared with those with stages II, III, and IV tumours. It is thus noteworthy that stage II tumours represent a truly advanced disease entity warranting a more aggressive treatment approach.

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Section: Karoliina Hirvonen Shared First Authorshipmentioning

confidence: 99%

Early stage minor salivary gland adenoid cystic carcinoma has favourable prognosis

et al. 2017

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“…The remaining 1496 abstracts were screened for eligibility, yielding 131 manuscripts. Their full text evaluation identified 64 studies meeting the inclusion criteria 17–80 …”

Section: Resultsmentioning

confidence: 99%

“…Eighteen studies (28.1%) analyzed 946 primary minor SGCs and reported treatment of 426 recurrences (45.0%) 20–22,26,27,32–34,40,44,47,50,52,56,63,67,76 . Twenty‐five articles (39.1%) analyzed 1568 primary major SGCs and reported treatment of 570 recurrences (36.3%) 17,25,31,35,36,38,40,41,42,45,46,49,57,59,60,62,64,68,69,71,73,75,77–79 .…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen publications (20.3%) had a study period longer than 30 years 21,27,32,34,43,56,58,65,67,75–77,80 . On the other hand, only 5 articles (7.8%) 35,49,50,57,70 reported a study period shorter than 10 years. The remaining 46 papers (71.9%) presented a median study period of 16 years 17–20,22–26,28–31,33,36–42,44–48,51–55,59–64,66,68,69,71–74,78,79 …”

Section: Resultsmentioning

confidence: 99%

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Estimating survival after salvage surgery for recurrent salivary gland cancers: Systematic review

et al. 2022

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Recurrent salivary gland carcinomas (RSCs) are poorly characterized and their clinical features and treatment options have not yet been fully described. The goal of this study was to analyze the therapeutic strategies and oncological outcomes of RSC patients through a literature review analysis. This systematic review was performed according to the PRISMA statements. Inclusion criteria for the systematic review were based on the population, intervention, comparison, and outcomes according to (PICO) framework. Two thousand seven hundred and four records were selected and 1817 recurrences were studied. Three hundred and sixty-five patients underwent salvage surgery (20.1%) and their

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“…While inconsistent findings were reported by Iqbal H. et. al 8. Although demographic data from few studies countrywide, gives an insight of the biological and clinical characteristics of the tumours in head and neck region.…”

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confidence: 99%

Demography and Histopathological presentations of oral and maxillo-facial region tumours in Jamshoro, Pakistan.

Munawar Ali Baloch,

Ikramuddin Ujjan,

Mehnaz Munawar

2019

j Muhammad Med Coll

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Introduction: Oral and Pharyngeal cancers are the sixth most common cancer globally. In developing countries, the annual incidence of oral cancer is around 275,000 cases while 130,300 cases of pharyngeal cancers excluding naso-pharynx. Salivary glands tumors are rare accounting for less than 5 % of tumors of head and neck region. The annual incidence of these tumors is 0.05 to 2 cases per 100,000 populations. Majority (over two third quarters) of salivary gland tumors occurs in the parotid glands of which most of them (2/3rd) of them are benign in nature. While most common parotid gland’s benign tumor is Pleomorphic Adenoma. Objective: To assess the morphology and histopathological features of oral and maxillo-facial region tumours among the patients in Liaquat University Hospital, Jamshoro, Sindh. Methodology: A Cross-sectional study was conducted at Liaquat University Hospital, Jamshoro. Data was collected regarding socio-demographic features, anatomical location of tumours and relevant history of patients admitted at surgical, medical and ENT units of Liaquat University Hospital, Jamshoro from January 2016 to January 2018. Histopathological diagnostic record was collected from Research and Diagnostic Laboratory of Liaquat University Hospital, Jamshoro. Results: A total of 160 biopsies were collected from surgical, medical and ENT units of Liaquat University Hospital with maximum (43%) of biopsies were from ENT unit. Most (51%) tumours were benign and 37% were malignant in nature. These tumours of oral and maxillo-facial region were mostly (38%) located in parotid region. Histopathological findings of this study revealed that majority (51%) tumours were Pleomorphic adenoma while (20%) of malignant tumours were Mucoepidermoid Carcinoma. Conclusion: Based on findings of the study, we conclude that the most common anatomical location of oral and faciomaxillary tumours, in either gender, is parotid region. The majority of oral and faciomaxillary tumours were benign; frequently occurring benign tumour was pleomorphic adenoma while most frequent malignant tumour was Muco-epidermoid Carcinoma. Key Words: Faciomaxillary tumours, Salivary glands, Pleomorphic adenoma.

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Survival outcome of malignant minor salivary tumors in Pakistani population

Cited by 4 publications

References 23 publications

Early stage minor salivary gland adenoid cystic carcinoma has favourable prognosis

Early stage minor salivary gland adenoid cystic carcinoma has favourable prognosis

Estimating survival after salvage surgery for recurrent salivary gland cancers: Systematic review

Demography and Histopathological presentations of oral and maxillo-facial region tumours in Jamshoro, Pakistan.

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