2021
DOI: 10.3390/cancers13040803
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Survival Outcomes with Photodynamic Therapy, Chemotherapy and Radiation in Patients with Stage III or Stage IV Non-Small Cell Lung Cancer

Abstract: Data regarding the association between photodynamic therapy (PDT) and mortality in lung cancer patients are limited. We analyzed the association between PDT and mortality in patients with stage III or IV non-small cell lung cancer (NSCLC) using data from the National Cancer Database (NCDB) between 2004 and 2016. From the NCDB, we identified patients receiving laser ablation/cryosurgery or local tumor destruction/excision (which includes PDT). From Medicare and Medicaid claims between 2000 and 2013, we identifi… Show more

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Cited by 23 publications
(14 citation statements)
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“…In terms of diagnosed cases and associated deaths, one of the top three cancers in the US is lung cancer [13]. Chemotherapy is the dominant treatment modality, yet cancer cells develop drug resistance and no longer respond to therapy after a while.…”
Section: Malignant Diseasesmentioning
confidence: 99%
See 3 more Smart Citations
“…In terms of diagnosed cases and associated deaths, one of the top three cancers in the US is lung cancer [13]. Chemotherapy is the dominant treatment modality, yet cancer cells develop drug resistance and no longer respond to therapy after a while.…”
Section: Malignant Diseasesmentioning
confidence: 99%
“…Consequently, a new treatment strategy must be applied, either after chemotherapy becomes inefficient or as the main treatment modality [119]. In this respect, PDT has a long history of clinical success, being FDA-approved for the ablation of microinvasive endobronchial non-small cell lung cancer (NSCLC) not suitable for other treatments and of completely or partially obstructive endobronchial NSCLC [11,13,120].…”
Section: Malignant Diseasesmentioning
confidence: 99%
See 2 more Smart Citations
“…As of date, cancer ablative potential of PDT has been applied clinically to treat multiple types of cancers including skin cancer ( Braathen et al, 2007 ; Zhang et al, 2022 ), head and neck cancer ( Ahn et al, 2014 ; Meulemans et al, 2019 ), gastric cancer ( Yano and Wang, 2020 ), brain cancer ( Li et al, 2022 ), breast cancer ( George and Abrahamse, 2016 ; Dos Santos et al, 2020 ), non-small-cell lung cancer ( Chhatre et al, 2021 ), genitourinary cancer ( Bozzini et al, 2012 ; Osuchowski et al, 2021 ), and more, and most of which achieved satisfactory clinical effect. In spite of this, the depth and breadth of its clinical application have not been fully exploited due to the limitations such as oxygen deficiency within the tumor microenvironment, inadequate light penetration depth, insufficient bioavailability and targeting of PSs, and the immune escape of tumor cells ( O'Connor et al, 2009 ; Cheng et al, 2015 ).…”
Section: Introductionmentioning
confidence: 99%