Survival Prediction Capabilities of Preoperative Inflammatory and Nutritional Status in Esophageal Squamous Cell Carcinoma Patients

Sugawara, Katsuhiko; Yagi, Koichi; Okumura, Yasuhiro; Aikou, Susumu; Yamashita, Hiroharu; Seto, Yasuyuki

doi:10.1007/s00268-021-06398-5

Cited by 12 publications

(12 citation statements)

References 46 publications

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“…Clinical and histological tumor staging was based on the TNM classification (UICC, 8th edition) [17]. As a nutritional parameter, Onodera's prognostic nutritional index (PNI: 10 × albumin + 0.005 × total lymphocyte count) was calculated [18]. The Glasgow prognostic score (GPS) was estimated as an inflammatory marker, as previously described [19].…”

Section: Methodsmentioning

confidence: 99%

Survival Impacts of Impaired Lung Functions and Comorbidities on Elderly Esophageal Cancer Patients

Sugawara,

Oka,

Hara

et al. 2023

World j. surg.

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Background Preoperative physiological assessments are crucial for optimizing clinical outcomes, especially those of elderly esophageal cancer (EC) patients who are generally frail and at the high risk of mortality. Methods Patients who underwent surgery for EC between 2004 and 2018 were retrospectively reviewed. Patients were categorized into elderly ([70 years) or non-elderly (B70 years) groups. Various physiological parameters including the Charlson Comorbidity Index (CCI), immunonutritional parameters and pulmonary functions were studied. Pulmonary functions included %vital capacity (VC) and forced expiratory volume in one second (FEV1.0) and FEV1.0%. The thresholds were set as the lowest quartile (100% for %VC and 2L for FEV1.0) in this cohort. Multivariate Cox hazards models were applied to determine independent predictors of non-EC-related deaths. Results In total, 824 patients were included (elderly; n = 306, non-elderly; n = 518). Elderly patients had a significantly lower 5-year OS rate than non-elderly patients (53.3% vs. 57.2%, P = 0.03), mainly due to increased risk of death from non-EC related causes. In the elderly group, multivariate Cox hazards analysis identified 3 independent predictors of non-EC-related deaths; high CCI (HR 1.98, P=0.006), low %VC (HR 2.01, P = 0.004) and low FEV1.0 (HR 1.6, P=0.048). Elderly patients without risk factors had a significantly better 5-year OS rate (63.5%) than those with 1 (50.0%) or 2-3 (36.3%) risk factors (P \0.01). Deaths due to pulmonary disease rose significantly as the number of risk factors increased (P=0.03). Conclusions The severity of comorbidities and pulmonary function impairments are useful for predicting long-term outcomes, especially non-EC-related deaths, in elderly EC patients.

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Section: Methodsmentioning

confidence: 99%

Survival Impacts of Impaired Lung Functions and Comorbidities on Elderly Esophageal Cancer Patients

Sugawara,

Oka,

Hara

et al. 2023

World j. surg.

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“…Clinical and histological tumor staging was based on the TNM classification (UICC, 8th edition) [ 15 ]. As a nutritional parameter, Onodera’s prognostic nutritional index (PNI: 10 × albumin + 0.005 × total lymphocyte count) was calculated [ 16 ]. The Glasgow prognostic score (GPS) was determined and the neutrophil-to-lymphocyte ratio (NLR) was estimated as an inflammatory marker, as previously described [ 17 , 18 ].…”

Section: Methodsmentioning

confidence: 99%

Survival outcomes of esophageal cancer patients with recurrence after curative treatments

Sugawara,

Oka,

Hara

et al. 2023

BMC Cancer

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Background Little is known about predictive factors for survival outcomes of esophageal carcinoma (EC) patients who developed recurrence after undergoing multimodal therapies. We aimed to investigate long-term outcomes and identify prognostic factors in patients with relapsed EC, focusing especially on those with oligometastasis (OM). Methods EC patients who developed recurrence after curative treatments (radical esophagectomy or definitive chemoradiotherapy (dCRT)) between 2010 and 2017 were reviewed. Multivariate Cox hazards models were applied to determine independent predictors of poor post-recurrence survival (PRS). Results In total, 178 patients were included. The median PRS was 12.9 months. Of the 178 patients, 98 had OM and 80 non-OM (NOM) disease. The survival outcomes of patients with OM were significantly better than those of patients with NOM (P < 0.01). Surgical treatments provided significantly better survival outcomes than CRT or chemo-/radiotherapy alone (3-year overall survival (OS); 78.1% vs. 42.5% vs. 28.9%, P < 0.01), mainly due to prolonging survival after the recurrence (3-year PRS 62.9% vs. 16.7% vs. 16.2%, P < 0.01). Multivariable analysis focusing on patients with OM revealed cStage III-IV disease (P < 0.01), high GPS at the time of recurrence (P = 0.02) and non-curative treatments (P < 0.01), to be independently associated with poor PRS. In contrast, in patients with NOM, no independent predictors for poor PRS were identified. Conclusions The survival outcomes of patients with relapsed EC remain poor. Surgical treatments could provide survival benefits for patients with recurrent EC, especially for patients with OM.

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“…After reviewing the titles, abstracts and full texts, 10 studies were included eventually. [21][22][23][24][25][26][27][28][29][30] Detailed process is presented in Figure 1.…”

Section: Literature Search Processmentioning

confidence: 99%

Predictive role of Naples prognostic score for survival in esophageal cancer: A meta-analysis

Guo,

Wang

2024

Medicine

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Background: To further clarify the predictive value of pretreatment Naples prognostic score (NPS), calculating based on the serum albumin concentration, total cholesterol level, neutrophil to lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR), among esophageal cancer patients based on available evidence. Methods: The PubMed, EMBASE, Web of Science and CNKI databases were searched up to December 1, 2023 for relevant studies. Overall survival (OS), progression-free survival (PFS) and cancer-specific survival (CSS) were endpoints and the hazard ratio (HR) with 95% confidence interval (CI) was combined to evaluate the predictive role of NPS for survival. Subgroup analysis based on pathological type and treatment were further conducted. Results: Ten retrospective studies with 2250 cases were included in our analysis. Pooled results demonstrated that higher pretreatment NPS predicted poorer OS (HR = 2.24, 95% CI: 1.57–3.20, P < .001), PFS (HR = 3.03, 95% CI: 1.84–4.98, P < .001) and CSS (HR = 2.90, 95% CI: 1.80–4.68, P < .001). Then subgroup analysis for the OS and PFS stratified by the pathological type (squamous cell carcinoma vs esophageal cancer) and treatment (surgery vs non-surgery) were further conducted, which showed similar results. Conclusion: Pretreatment NPS is significantly associated with prognosis in esophageal cancer and higher NPS predicts worse survival among patients with esophageal cancer.

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Survival Prediction Capabilities of Preoperative Inflammatory and Nutritional Status in Esophageal Squamous Cell Carcinoma Patients

Cited by 12 publications

References 46 publications

Survival Impacts of Impaired Lung Functions and Comorbidities on Elderly Esophageal Cancer Patients

Survival Impacts of Impaired Lung Functions and Comorbidities on Elderly Esophageal Cancer Patients

Survival outcomes of esophageal cancer patients with recurrence after curative treatments

Predictive role of Naples prognostic score for survival in esophageal cancer: A meta-analysis

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