Survival prediction of anxious emotion in advanced cancer patients receiving palliative care

Zhao, Weiwei; Wu, Zhenyu; Chen, Jianhua; Jia, Huixun; Huang, Zhe; Chen, Menglei; Gu, Xihui; Liu, Minghui; Zhang, Zhe; Wang, Huaping; Wang, Peng; Cheng, Wenwu

doi:10.1002/pon.4314

Cited by 3 publications

(4 citation statements)

References 30 publications

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“…Consistent results were found in previous studies. Anxious emotion has previously been associated with poor survival in advanced cancer patients [33]. Our results add more evidences to support that interventions to improve emotional and stress management might have a positive impact on survival.…”

Section: Discussionsupporting

confidence: 78%

Prognostic Value of Post-diagnosis Health-Related Quality of Life for Overall Survival in Breast Cancer: Findings from a 10-Year Prospective Cohort in Korea

et al. 2019

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PurposeWe aimed to evaluate health-related quality of life (HRQOL) at 1-year post-diagnosis in breast cancer (BC) patients and its association with overall survival using data from the National Cancer Center Hospital.Materials and MethodsData of a BC cohort were first obtained between 2004 and 2006 and followed up. HRQOL was assessed using EORTC QLQ-C30 and BC specific module QLQ-BR23 few days after diagnosis and 1 year after that. We examined and compared the difference in the two HRQOL scores measured for each patient by the patient’s current survival status. The Cox proportional hazards model was fitted to evaluate the impact of HRQOL on survival, with adjustment for baseline HRQOL and other factors.ResultsOf 299 enrolled patients, 206 responded at 1-year post-diagnosis (80.6%) and were followed up for 11.6 years on average. At 1-year post-diagnosis, survivors had better HRQOL scores than those who died, although their health status was similar at baseline. Survivors reported significant increase 1 year after diagnosis in global health status and emotional scales. Between the groups, functional scales such as physical, role, and emotional were significantly different. Functional scales, including physical (adjusted hazard ratio [aHR], 0.70), role (aHR, 0.68), emotional (aHR, 0.72), and symptom scales, including fatigue (aHR, 1.34), dyspnea (aHR, 1.29), appetite loss (aHR, 1.24) were significantly associated with overall survival. Patients who were less worried about future health had favorable survival(aHR, 0.83).ConclusionBesides treatment-related symptoms, non-medical aspects at 1-year post-diagnosis, including functional well-being and future perspective, are predictive of long-term survival. Intervention to enhance physical, role, and emotional support for women soon after their BC diagnosis might help to improve disease survival outcomes afterwards.

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Section: Discussionsupporting

confidence: 78%

Prognostic Value of Post-diagnosis Health-Related Quality of Life for Overall Survival in Breast Cancer: Findings from a 10-Year Prospective Cohort in Korea

et al. 2019

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“…Patients with advanced stage would be more likely to be affected by emotional distress than patients with early stage. According to a previous study with 377 advanced cancer patients receiving palliative care, higher anxiety was an independent prognostic indicator of overall survival in men (HR: 1.81, P =0.003) 29 . Since advanced stage patients have an extremely vulnerable status, the potential mechanisms of higher distress and poor survival, including immunity and adherence, could have a much greater impact on patients with advanced stage disease 29,30 .…”

Section: Discussionmentioning

confidence: 99%

“…According to a previous study with 377 advanced cancer patients receiving palliative care, higher anxiety was an independent prognostic indicator of overall survival in men (HR: 1.81, P = 0.003). 29 Since advanced stage patients have an extremely vulnerable status, the potential mechanisms of higher distress and poor survival, including immunity and adherence, could have a much greater impact on patients with advanced stage disease. 29,30 Early palliative care, which reduces distress could assist in complex symptom management and advance care planning.…”

Section: Discussionmentioning

confidence: 99%

“…29 Since advanced stage patients have an extremely vulnerable status, the potential mechanisms of higher distress and poor survival, including immunity and adherence, could have a much greater impact on patients with advanced stage disease. 29,30 Early palliative care, which reduces distress could assist in complex symptom management and advance care planning. 31 According to a previous study, when the patients received coordinating care on the basis of individual needs of the patient based on assessing physical and psychosocial symptoms, median survival was longer (11.6 mo vs. 8.9 mo, P = 0.02) than patients with standard care.…”

Section: Discussionmentioning

confidence: 99%

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Association Between Distress at Diagnosis and Disease-free Survival Among Patients With Resectable Colon Cancer: A Large Cohort Study

et al. 2023

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Objective: This study aimed to evaluate the association between distress at initial diagnosis and disease-free survival in patients with resectable colon cancer. Summary Background Data: Considerable research has examined the psychological impact of having a confirmed diagnosis of cancer, but relatively limited research has examined the impact of distress during the diagnostic phase on oncological outcomes. Methods: This is a retrospective cohort study. We included newly diagnosed colon cancer patients who had resectable surgery and underwent distress screening between July 2014 and July 2021 (N=1,362). The Korean versions of the Distress Thermometer were used to assess distress and related problems. Patients were categorized into 3 groups based on distress score: low (<4), moderate (4–7), and severe (≥8). The primary outcome was disease-free survival. Results: The mean distress was 5.1 (SD=2.4) and 61%, and 15% of patients had moderate and severe distress at diagnosis, respectively. The severe distress group was more likely to report fear, sadness, and concerns regarding insurance/finance, work, and childcare than the low distress group. Compared with the low distress group, the severe distress group had worse disease-free survival (Hazard Ratio=1.84, 95% CI=1.03, 3.29). The association was more evident in patients with stage IV disease (Hazard Ratio=2.53, 95% CI=1.02, 6.25). Conclusions: A substantial number of patients with colon cancer experience distress at diagnosis, and severe distress has a negative impact on oncologic outcomes. Active monitoring and appropriate management of distress at diagnosis should be adopted at clinical settings.

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Progress in psycho-oncology with special reference to developing countries

Murthy

Alexander

2019

Current Opinion in Psychiatry

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Survival prediction of anxious emotion in advanced cancer patients receiving palliative care

Abstract: Background This study was carried out to investigate the prognostic value of baseline and

Cited by 3 publications

References 30 publications

Prognostic Value of Post-diagnosis Health-Related Quality of Life for Overall Survival in Breast Cancer: Findings from a 10-Year Prospective Cohort in Korea

Prognostic Value of Post-diagnosis Health-Related Quality of Life for Overall Survival in Breast Cancer: Findings from a 10-Year Prospective Cohort in Korea

Association Between Distress at Diagnosis and Disease-free Survival Among Patients With Resectable Colon Cancer: A Large Cohort Study

Progress in psycho-oncology with special reference to developing countries

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