Survival probability and prognostic factors of Iranian breast cancer patients using cure rate model

Abstract

Breast cancer, the major concern of the global health, is the fifth cause of death of women in Iran. In this longitudinal study, 3048 cases of breast cancer who visited and were treated at the Cancer Research Center in Shahid Beheshti University, were studied. During study, 518 patients died. The overall survival rate of 1, 5, 10, 15, and 20-year were 95%, 76%, 59%, 47% and 46%, respectively. A significant relation was observed between survival time and the variables such as age, size of tumor, number of lymph nodes, stage, grade, and lymphovascular invasion. K E Y W O R D S breast cancer, cure fraction models, generalized Birnbaum-Saunders, negative binomial, survival probability 1 | INTRODUCTION Breast cancer is the second cause of cancer mortality worldwide and the fifth cause of mortality in Iranian women. 1-8 Based on the 2016statistics, the 5-year survival rate for breast cancer were 73% and 53% for the developed and developing countries respectively. 9The incidence of breast cancer in Iran was 7582 cases (23% of total cancers in women) in 2009 and its age was unfortunately decreasing. 1The 1-year,3-year, 5-year, and 10-year survival rate of breast cancer in

Long-term Survival and Prognostic Factors of Breast Cancer

“…9 Other studies in Iran have reported 5-, 7-, 10-, and 15-year breast cancer survival rates of about 45%–92%, 54.8%–76%, 31%–77%, and 46%, respectively. 10 , 31 , 32 Similarly, in the past decade, patients’ survival rates improved from 85% to 90% in the USA and from 60% to 74% in Eastern Europe. 31 Although our results indicate improvements in the breast cancer survival rate in Iran, it should be considered that MCI is a semi-public center with a multidisciplinary treatment protocol.…”

A new 21-Gene Expression Assay Recurrence Score in Estrogen Receptor-Positive and Lymph Node-Negative Early-Stage Breast Cancer Patients

“…Breast cancer is the most prevalent form of cancer and fth-leading cause of death among Iranian women [4]. In recent years, the standard incidence rate (SIR) of this cancer has increased to approximately 28 per 100,000 people [5]. There are numerous well-established and controversial breast cancer risk factors, despite the American Cancer Society's claim that only about a quarter of breast cancers have risk factors identi ed [3,4].…”