Survival rate after D3-lymphadenectomy for right-sided colic cancer: case-match study

Tsarkov, Petr; Efetov, Sergey; Tulina, Inna; Kravchenko, A.Yu.; Fedorov, D. N.; Efetov, S V

doi:10.17116/hirurgia20151272-79

Cited by 5 publications

(3 citation statements)

References 24 publications

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“…Patients with CRC who received D3/D2 lymphadenectomy have superior OS. [30][31][32] To avoid this limitation, we only enrolled patients with at least twelve harvested lymph nodes. Second, detailed information about chemotherapy was not recorded in the SEER database.…”

Section: Discussionmentioning

confidence: 99%

Tumor Deposits and Perineural Invasion had Comparable Impacts on the Survival of Patients With Non-metastatic Colorectal Adenocarcinoma: A Population-Based Propensity Score Matching and Competing Risk Analysis

et al. 2022

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Background Both tumor deposits (TD) and perineural invasion (PNI) have been identified as risk factors for poor survival in patients with non-metastatic colorectal adenocarcinoma (CRC). However, the adverse impacts of TD and PNI on the survival of patients with non-metastatic CRC have not been compared. Method Patients with non-metastatic CRC with known TD and PNI status were selected from the Surveillance, Epidemiology, and End Results (SEER) database. First, bivariate logistic regression analysis was utilized to identify the factors associated with TD and PNI status. Then, patients were divided into four groups, according to TD and PNI status. Propensity score matching (PSM) was performed to balance the baseline covariates. The impact of TD and PNI on survival was assessed by analyzing overall survival (OS) and cancer-specific mortality (CSM) rates. OS was calculated by the Kaplan–Meier method with log-rank analysis. CSM was estimated by competing risk analysis using the Fine and Gray model. Results A total of 70 689 patients with CRC met the inclusion and exclusion criteria. The positive rates of TD and PNI were 9.37% and 9.91%, respectively. For TD, the most important risk factor was N stage. With respect to PNI, the most significant factor was T stage. Tumor location, tumor size, differentiation grade, and serum CEA level were also correlated with TD and PNI status. After PSM, 1849 pairs were selected. Patients with TD+PNI+ status had the worst 5 year CSM and 5 year OS. In addition, the long-term survival outcomes of patients with TD+PNI− and TD−PNI+ status were comparable. Conclusion The adverse impacts of TD and PNI on the survival of patients with non-metastatic CRC were comparable. CRC patients with both TD and PNI positive had the worst survival outcome.

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Section: Discussionmentioning

confidence: 99%

Tumor Deposits and Perineural Invasion had Comparable Impacts on the Survival of Patients With Non-metastatic Colorectal Adenocarcinoma: A Population-Based Propensity Score Matching and Competing Risk Analysis

et al. 2022

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“…The primary objective of both techniques is to enhance overall and disease-free survival. Numerous non-randomized controlled trials have demonstrated the superiority of D3 lymph node dissection over D2 in terms of overall and disease-free survival [ 9 – 12 ]. Other authors have shown comparable long-term results [ 13 , 14 ].…”

Section: Background and Rationalementioning

confidence: 99%

Comparison of D2 vs D3 lymph node dissection for RIght COloN cancer (RICON): study protocol for an international multicenter open-label randomized controlled trial

Balaban,

Mutyk,

Bondarenko

et al. 2024

Trials

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Background Colon cancer is a global health concern, ranking fifth in both new diagnoses and deaths among tumors worldwide. Surgical intervention remains the primary treatment for localized cases, with a historical evolution marked by a focus on short-term outcomes. While Japan pioneered radical tumor removal with a systematic categorization of lymph nodes (D1, D2, D3), the dissemination of Japanese practices to the West was delayed until 90th of last century. Discrepancies between Japanese D3 dissection and the CME with CVL principle persist, with variations in longitudinal margins and recommended procedures. Non-randomized trials indicate the superiority of D3 over D2, but a consensus is lacking. Methods This prospective, international, multicenter, randomized controlled trial employs a two-arm, parallel-group, open-label design to rigorously compare the 5-year overall survival outcomes between D2 and D3 lymph node dissection in stage II-III right colon cancer. Building on prior studies, the trial aims to address existing knowledge gaps and provide a comprehensive evaluation of the outcomes associated with D3 dissection. The study population comprises patients with right colon cancer, ensuring a focused investigation into the specific context of this disease. The trial design emphasizes its global scope and collaboration across multiple centers, enhancing the generalizability of the findings. Discussion This study’s primary objective is to elucidate the potential superiority in 5-year overall survival benefits of D3 lymph node dissection compared to the conventional D2 approach in patients with stage II-III right colon cancer. By examining this specific subset of patients, the research aims to contribute valuable insights into optimizing surgical strategies for improved long-term outcomes. The trial’s international and multicenter nature enhances its applicability across diverse populations. The outcomes of this study may inform future guidelines and contribute to the ongoing discourse surrounding the standardization of colon cancer surgery, particularly in the context of right colon cancer. Trial registration ClinicalTrials.gov NCT03200834. Registered on June 27, 2017.

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“…В данном обзоре предполагается, что лимфаденэктомия в объеме D3 превосходит таковую в объеме D2, улучшая отдаленные результаты в отношении кровопотери, количества полученных ЛУ и 3-и 5-летней общей и безрецидивной выживаемости [62]. Схожие результаты наблюдались при анализе других исследований [63,64]. При рассмотрении вопроса о выборе объема лимфаденэктомии при правосторонней локализации рака следует упомянуть исследование Y. Kanemitsu и соавт.…”

Section: стандарты лимфаденэктомииunclassified

Optimized surgical tactics for localized colon cancer (literature review)

Matveev

Danilov

Аллахвердиев

et al. 2022

Onkol. koloproktol.

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Survival rate after D3-lymphadenectomy for right-sided colic cancer: case-match study

Cited by 5 publications

References 24 publications

Tumor Deposits and Perineural Invasion had Comparable Impacts on the Survival of Patients With Non-metastatic Colorectal Adenocarcinoma: A Population-Based Propensity Score Matching and Competing Risk Analysis

Tumor Deposits and Perineural Invasion had Comparable Impacts on the Survival of Patients With Non-metastatic Colorectal Adenocarcinoma: A Population-Based Propensity Score Matching and Competing Risk Analysis

Comparison of D2 vs D3 lymph node dissection for RIght COloN cancer (RICON): study protocol for an international multicenter open-label randomized controlled trial

Optimized surgical tactics for localized colon cancer (literature review)

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