Survival rate after paraquat poisoning: impact of emergency clinical and laboratory variables

Abstract

Objective: to analyze the association of survival to emergency care measures, clinical symptoms and biochemical markers used for paraquat intoxicated patients. Methods: retrospective cohort, guided by the Strengthening the Reporting of Observational Studies in Epidemiology tool. The data collection and analysis protocol were based on two phases: first, with the survey of the investigation forms of exogenous poisoning from the Secretariat of Epidemiological Surveillance; second, with the analysis of information in printed medical records. Results: of the 36 (100%) patients investigated, 19 (53.0%) survived; regarding the clinical manifestations, there was statistical significance for the respiratory system (p=0.003); regarding the biochemical variables, there was statistical significance for liver enzymes. The initial emergency measures 13(56.5%) of survivors received gastric lavage with activated charcoal. Conclusion: we observed a lack of efficacy of the impacts of emergency care measures and medications in increasing patient survival.

Características sociodemográficas y clínicas relacionadas con la condición final de pacientes intoxicados por paraquat en un hospital del suroccidente de Colombia

“…Los tratamientos más utilizados en la intoxicación por paraquat son los adsorbentes gástricos, la filtración extracorpórea y el manejo farmacológico con antioxidantes, antiinflamatorios e inmunosupresores (21). Se hace seguimiento clínico y de los marcadores bioquímicos para determinar la reacción terapéutica del paciente y los criterios pronósticos de supervivencia (22)(23)(24).…”