Survival Rate in Autotransplanted Premolars with Complete Root Formation: A Retrospective Clinical Survey

Fidalgo

2019

CRORJ

Palavras-Chave:Endodontia. Autotransplante. Rizogênese Completa.RESUMO Objetivo: O objetivo da presente revisão da literatura foi verificar as taxas de sucesso, assim como seus fatores predisponentes, do autotransplante dentário em dentes com rizogênese completa. Métodos: Uma busca eletrônica foi executada no PubMed usando MeSH terms e termos livres específicos. Inicialmente, um total de 115 títulos e resumos foram identificados. Um estudo adicional foi identificado como relevante após uma busca das listas de referência. Após a aplicação dos critérios de elegibilidade, apenas 8 artigos foram selecionados. Resultados: De forma geral, os estudos incluídos demonstram elevadas taxas de sucesso, baseado nos parâmetros estabelecidos, como manutenção do ligamento periodontal, cicatrização periapical e saúde periodontal. Além disso, os estudos selecionados na presente revisão apontaram que fatores como os protocolos de extração e reimplante, o tempo de proservação utilizado no estudo e o tempo no qual foi realizado o tratamento endodôntico do elemento transplantado, podem afetar a taxa de sucesso do autotransplante dentário. Conclusão: De acordo com a presente revisão de literatura pode-se concluir que embora ainda existam poucos estudos de autotransplante realizados em pacientes com rizogênese completa, a técnica tem se mostrado uma opção viável e com moderada taxa de sucesso para a substituição de elementos dentários perdidos. ABSTRACT Objective:The objective of the present literature review tis o verify the success rates, as well as the predisposing factors, associated to success rates of dental autotransplant treatments in teeth with complete rhizogenesis. Methods: An electronic search was performed on PubMed database using MeSH terms and free terms. Initially, a total of 115 titles and abstracts. An additional study was identified as relevant after a search of reference lists. After eligibility criteria appliance, only 8 articles were selected. Results: In general, the included studies show high success rates, based on established parameters such as periodontal ligament maintenance, periapical healing and periodontal health. In addition, the selected studies pointed out that factors such as extraction and reimplantation protocols, the time of follow-up used in the study and the time in which the endodontic treatment of the transplanted element was performed, can affect the success rate of dental transplant therapy. Conclusion: According to the present literature review, it can be concluded that although there are still few studies of autotransplantation performed in patients with complete rhizogenesis, the technique has proven itself as a viable option with moderate success rate for replacement of lost dental elements.

Section: Discussionmentioning

confidence: 94%

“…The complete text of the remaining articles (n = 8) was obtained and submitted to independent judged by each of the evaluators. [7][8][9][10][11] The eight studies met the inclusion criteria and were included in the present literature review. Table 1 presents the main results obtained in the articles selected for the present literature review.…”

Section: Resultsmentioning

confidence: 99%

Autotransplantation of teeth with complete rhizogenesis: a literature review

Fidalgo

2019

CRORJ

“…The immediate reinsertion of healthy, freshly extracted teeth with the tooth-sided part of the ruptured PDL still attached, has been reported time and again as highly successful (Andreasen et al 1990;Cross et al 2013;Yoshino et al 2013). By removing apex and pulp tissue from such teeth and cultivating the roots as series of consecutively cut, transversal sections, such pulp-free slices may retain the properties of the residual PDL to propagating successful tooth reintegration, and unfold the "innate potential of the periodontal tissue in providing meaningful periodontal regeneration" (Lin et al 2015) in vitro, as do freshly extracted teeth with intact root surfaces in vivo.…”

Section: Discussionmentioning

confidence: 99%

“…Tooth extraction ruptures the PDL and its vasculature and stimulates in the residual PDL a. o. stem/progenitor cells to initiate reattachment and PDL restoration (Gould et al 1977;Pitaru et al 1994Pitaru et al , 2014Sato et al 2010). Numerous serial case studies document that freshly extracted and reinserted healthy autologous teeth have a high chance to regain function (Andreasen 1990;Cross et al 2013;Yoshino et al 2013). Prerequisites are that i) reinsertions are done at once or upon appropriate storage (Andreasen & Kristersson 1981;Temmerman 2006;Malhotra 2011), and that ii) mature roots are endodontically treated (Schwartz & Andreasen 1988).…”

Section: Introductionmentioning

confidence: 99%

Periodontal ligament on pulp-free root slices – an in vitro model for early tooth (re)integration

Baschong,

Weiss,

Imholz

et al. 2018

Swiss Dent. J. SSO

Reintegration of freshly extracted healthy teeth is very successful, most likely due to the regenerative capacity of their roots’ residual periodontal ligament (PDL). We hypothesised that in vitro cultures of the consecutive slices of a sectioned root will represent the entity of PDL cell types engaged in tooth-sided reintegration. For confirmation, apex and pulp from human premolars were removed and roots cut into 6 to 9 about 1 mm thick slices. These were immobilised to separate wells and cultured for 20 days, under daily inspection for the initiation of cell outgrowth (ICO). ICO and the distribution of vital slices along, the cell growth around as well as the expansion of outgrown cells off the root axes after 20 days were displayed for each tooth as 3D-like profiles. Of the 81 slices from 11 teeth, 55 showed ICO; 64% within one week and 96% within two weeks. Such dynamics compare to the early (day 2–5) and the intermediate (day 9–14) integration phase reported for PDL cells in vivo. Experimental phase contrast images of a single slice showed at ICO few fibroblast- and stem/progenitor- like cells. Four and five days later at the same site cells had grown in number and changed in shape and space over time. This exploratory study indicates that in root slice cultures PDL cells behave similarly to those during reintegration in vivo. It favours our hypothesis, which is now to be adequately verified. Eventually, the model may facilitate the identification of outgrowing cells and cellular changes over time, as triggered by tissue rupture. It may further allow for emulating cellular interactions between the root surface and alveolar bone or engineered constructs, natural or engineered scaffolds, or other tissue, in an in vivo-like situation.

Journal of Oral and Maxillofacial Surgery

“…[14][15][16][17][18][19] However, success can be achieved in cases of one-third or complete root formation. 20,21 To avoid extending cell damage to the root surface, the tooth should be removed gently from the donor site without extensive osteotomies or severe dislocations. 22 Minimizing the duration that a donor tooth is out of the mouth and the duration of root manipulation during autotransplantation are keys for success; however, in some cases, dentoalveolar ankylosis, root resorption, or even compromised root growth can occur.…”

Section: Discussionmentioning

confidence: 99%

Autotransplantation of Immature Third Molars and Orthodontic Treatment After En Bloc Resection of Conventional Ameloblastoma

Osterne

Neto

Lima

et al. 2015

Ameloblastoma treatment can lead to significant bone defects; consequently, oral rehabilitation can be challenging. We present the case of a 14-year-old girl diagnosed with a conventional ameloblastoma in the mandible who was treated using en bloc resection and rehabilitated with autotransplantation of the immature third molars and orthodontic treatment. The lesion was in the region of the lower left canine and premolars, and en bloc resection resulted in a significant alveolar bone defect. Autotransplantation of the lower third molars to the site of the lower left premolars was performed. After 2 years, the upper left third molar was transplanted to the site of the lower left canine. During the orthodontic treatment period, considerable alveolar bone formation was observed in the region of the transplanted teeth, and roots developed. To the best of our knowledge, this is the first reported case of alveolar bone formation induction caused by tooth transplantation after ameloblastoma treatment.