Survival Rate of Early Stage Endometrioid Adenocarcinoma of Endometrium Treated at Srinagarind Hospital

Krusun, Srichai; Pesee, Montien; Rasio, Withee; Tangvoraphonkchai, Vorachai; Supaadirek, Chunsri; Thamronganantasakul, Komsan; Supakalin, Narudom; Padoongcharoen, Prawat

doi:10.7314/apjcp.2014.15.5.2217

Cited by 7 publications

(7 citation statements)

References 15 publications

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“…Systemic lymphadenectomy is not necessary in ECs (Stage 1a-1c ECs) with low risk of lymph node involvement. [8] In addition, the noninvasive selective lymphadenectomy provides reliable data regarding the lymph node status and more beneficial than systemic lymphadenectomy in primary ECs. [9]…”

Section: Diagnostic Value Of Sentinel Lymph Nodes In Endometrial Cancersmentioning

confidence: 99%

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Sentinel lymph nodes in endometrial cancer update 2018

Abdelazim

Abu-Faza²,

Zhurabekova

et al. 2019

Gynecol Minim Invasive Ther

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There are no established data about lymphadenectomy during treatment of endometrial cancers (ECs) and to what extent lymphadenectomy should be performed. In addition, retroperitoneal lymphadenectomy increases the intraoperative and postoperative complications. Sentinel lymph node (SLN) mapping has the lowest costs and highest quality-adjusted survival. SLN is the most cost-effective strategy in the management of low-risk ECs. Women staged with SLN mapping were more likely to receive adjuvant treatment compared with women staged with systemic lymphadenectomy. This review article designed to evaluate the diagnostic accuracy and the methods of SLN detection in ECs.

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Section: Diagnostic Value Of Sentinel Lymph Nodes In Endometrial Cancersmentioning

confidence: 99%

“…Systemic lymphadenectomy is not necessary in women at low risk of lymph node involvement (Stage 1a-1c ECs). [8] Selective lymphadenectomy has been widely employed for staging evaluations of ECs because it is simple and provides reliable data regarding the lymph node status. [9]…”

Section: Introductionmentioning

confidence: 99%

Sentinel lymph nodes in endometrial cancer update 2018

Abdelazim

Abu-Faza²,

Zhurabekova

et al. 2019

Gynecol Minim Invasive Ther

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“…SLN is the first node receiving lymphatic drainage from primary tumor and pathological status of SLN should therefore reflect the overall status of entire lymphatic basin. Thus, a patient with negative SLN for metastasis may managed by SLN biopsy instead of a systemic lymphadenectomy (Krusun et al, 2014).…”

Section: Accuracy Of Sentinel Node In Detecting Lymph Node Metastasis In Primary Endometrial Carcinomamentioning

confidence: 99%

Accuracy of Sentinel Node in Detecting Lymph Node Metastasis in Primary Endometrial Carcinoma

Farghali

Allam²,

Abdelazim³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Endometrial carcinoma is the most common gynecological cancer and its treatment is still controversial, especially in its early stages. There are conflicting data about the efficacy of retroperitoneal lymphadenectomy during abdominal hysterectomy and bilateral salpingoophrectomy treatment. Lymphadenectomy carries a risk of severe complications, especially in women with co-morbidities. Selective lymphadenectomy has been widely employed for staging evaluation of endometrial carcinoma because it is simple and seems to provide reliable data regarding nodal metastasis. This study was designed to evaluate accuracy of sentinel node sampling in detecting lymph node metastasis in primary endometrial carcinoma during staging laparotomy. Materials and Methods: Ninety-three women with endometrial carcinoma at high-risk for nodal metastasis were studied. During laparotomy, methylene blue dye was injected into sub-serosal myometrium, then retroperitoneal spaces were opened and blue lymph nodes within pelvic and para-aortic regions were removed as separate specimens for histopathological examination (sentinel lymph nodes = SLNs). Hysterectomy and selective lymphadenectomy then performed for all women included in this study. Results: Deposition of methylene dye into at least one lymph node was observed in 73.1% (68/93) of studied cases. 18.3% (17/93) of studied women had positive lymph node metastasis and 94.1% (16/17) of them had positive metastasis in SLNs. In this study, SNLs had 94.4% sensitivity and 100% specificity in prediction of lymph node metastasis. Mean number of lymph nodes removed from each case decreased when SLNs biopsy were taken. Conclusions: SLNs are the key lymph nodes in endometrial tumor metastasis and their involvement could be an indicator for whether or not complete systematic lymphadenectomy is needed during staging laparotomy.

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“…Addition of postoperative RT showed an increase in local control (LC), with no significant effect on the management of these patients, thus, high-risk patients should particularly be considered for postoperative RT (Aalders et al, 1980;Creutzberg et al, 2000;Krusun et al, 2014).…”

Section: Introductionmentioning

confidence: 99%