Survival Rate of Liver Transplantation in Asia: A Systematic Review and Meta-Analysis

Abstract

Background: Liver transplantation is one of the most effective treatments for acute liver failure, chronic liver cirrhosis, and hepatocellular carcinoma. This study was implemented to evaluate the survival rate of liver transplant in Asia.
 Methods: Studies that investigated the survival rate of liver transplant were selected using a systematic search strategy in the following databases: Medline, Embase, Scopus, ProQuest, ISI Web of Science, and Cochrane to Nov 30th, 2020. Pooled survival rate and 95% confidence intervals were calculated using Der-Simonian and Laird method. Stata 16.0 (Stata Corp, College Station, TX, USA) was used for analysis.
 Results: One, 2, 3, 5, and 10-year survival rates of liver transplant were estimated to be 85%, 80%, 75%, 73%, and 71%, respectively. The results of the univariate meta-regression for defining the sources of heterogeneity for one-Year survival rate (SR) showed significant effects of bias (β high risk/ moderate risk =0.059, 95% CI: 0.002, 0.115, P-Value=0.04) and follow up time (β=-0.0002, 95% CI: -0.0003, -0.00, P-Value=0.02) on heterogeneity.
 Conclusion: The survival rate of liver transplant in Asia is comparable with the corresponding rate reported in the United States and Europe. This study provides a better view of the efficiency of medical cares, regarding liver transplantation. Medical care be enhanced to increase the survival of liver transplant patients.

Progress in the diagnosis and treatment of graft fibrosis after liver transplantation

“…After more than 60 years of innovation and development, liver transplantation (LT) has become a popular option for patients with end‐stage liver disease. Although the 1‐ and 5‐year survival rates of Asian LT recipients have been reported to be 85% and 73%, respectively, which are comparable to the rates reported in the United States and Europe, 1 graft fibrosis remains a common complication after LT. It has been reported by Scheenstra et al 2 that 34% (26/77) and 65% (43/66) of pediatric LT (PLT) patients experienced varying degrees of graft fibrosis at 1 and 5 years after surgery.…”

Usefulness of Diffusion-Weighted Imaging in Evaluating Acute Cellular Rejection and Monitoring Treatment Response in Liver Transplant Recipients

“…Liver transplantation is an effective way to prolong the life of patients with end-stage liver disease, with 5-year survival for over 70% of recipients [40][41][42]. While appropriate immunosuppression has reduced the risk of ACR, it remains the leading cause of graft dysfunction, occurring in about 20-70% of all transplant patients [43][44][45][46][47].…”