Survival rates during the first trimester of multiple gestations achieved by ICSI: a report of 1448 consecutive multiples

Uluğ, Ulun; Jozwiak, Esra Aksoy; Mesut, Ali; Berksoy, Mustafa Murat; Bahçeci, Mustafa

doi:10.1093/humrep/deh090

Cited by 20 publications

(17 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is interesting that EPL rates did not differ statistically among women over 35 years old. On the other hand, the sample size that achieved singleton [19][20]. It may be also questioned that poor ovarian responder patients in the antagonist arm may increase EPL; however, we have shown that poor ovarian response is not a risk factor for increased EPL [21].…”

Section: Short Communicationmentioning

confidence: 69%

Early pregnancy loss rates were different among singleton gestations conceived by ICSI using GnRH agonist and antagonist

Bahçeci

Uluğ

Şişmanoğlu

et al. 2009

J Assist Reprod Genet

View full text Add to dashboard Cite

This study compared early pregnancy losses (termination of pregnancy before 12 weeks of gestation, EPL) among conceptions achieved by ICSI according to the type of GnRH analogue for ovarian stimulation. Only singleton gestations (2,184) and fresh embryo transfers were included. GnRH agonist was used in 848 gestations out of 2,184 and GnRH antagonist was used in the remaining 1,336 gestations. EPL was found to be significantly higher in GnRH antagonist gestations compared to GnRH agonist (27.2% vs 18.9%). This significant difference persisted when gestations were segregated according to maternal age, especially among women younger than 35 years old. Therefore our results suggest that gestations conceived by ovarian stimulation including GnRH antagonists may have higher propabilty of having EPL.

show abstract

Section: Short Communicationmentioning

confidence: 69%

Early pregnancy loss rates were different among singleton gestations conceived by ICSI using GnRH agonist and antagonist

Bahçeci

Uluğ

Şişmanoğlu

et al. 2009

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…On the other hand, in numerous reports, clinical pregnancy was defined as the demonstration of fetal cardiac activity in which gestational sacs with yolk sacs without heartbeats were ignored although they have been recognized clinically. In other words, 8.5% of clinically identified gestations by sonography were considered somehow as preclinical pregnancy loss because they did not show viability later (24,25). However, our series exclusively consisted of subclinical pregnancies without any evidence of sonographic findings.…”

Section: Discussionmentioning

confidence: 97%

Subclinical Pregnancy Losses Among Women Undergoing In-Vitro Fertilization With ICSI

Uluğ

Tosun

Jozwiak

et al. 2006

J Assist Reprod Genet

View full text Add to dashboard Cite

Background:The purpose of this study is to asses the frequency of subclinical pregnancy loss (SPL) among women undergoing controlled ovarian hyperstimulation (COH) and in-vitro fertilization with ICSI. Methods: The study was retrospectively conducted in a private IVF center. SPL was defined by a temporary rise in serum βhCG, along with the absence of signs of intra-and extra-uterine pregnancy by transvaginal ultrasonography. Overall 5273 COH and ICSI cycles with embryo transfer (ET) were segregated according to serum E 2 levels percentiles (-24th, 25th, 74th, and 75th), women age and the type of spermatozoa for assisted fertilization (ejaculated and surgically retrieved). Those groups were assessed for SPL rates. Results: Among the 3125 (59.25) conception cycles, 305 (9.7%) were diagnosed as SPL. There was no difference in SPL rate among E 2 percentile groups. Women older than 35 years of age had significantly higher rate of SPL compared to younger women. There was also no difference in SPL rate among pregnancies in whom surgically retrieved spermatozoa used or ejaculated spermatozoa used for assisted fertilization. Conclusion: Our results demonstrated that SPL rate was not influenced by the levels of E 2 during COH or the origin of spermatozoa used for assisted fertilization. However, maternal age was found to be detrimental for SPL.

show abstract

“…La Sala et al (6) found age to be a significant factor only in IVF pregnancies resulting from conventional fertilization but not in those after ICSI. Interestingly, Ulug et al (5) failed to show any significant effect of age on loss with multiple pregnancies. Ulug et al (5) performed a retrospective analysis of 1,448 multiple pregnancies after IVF with ICSI and did not find a significant association between age and loss rate for multiple pregnancies.…”

Section: Discussionmentioning

confidence: 98%

“…Interestingly, Ulug et al (5) failed to show any significant effect of age on loss with multiple pregnancies. Ulug et al (5) performed a retrospective analysis of 1,448 multiple pregnancies after IVF with ICSI and did not find a significant association between age and loss rate for multiple pregnancies. However, they showed a significantly higher chance of spontaneous reduction to a twin or singleton pregnancy for a triplet pregnancy (11.7%) compared with a quadruplet pregnancy (3.5%).…”

Section: Discussionmentioning

confidence: 98%

Embryonic synergism may reduce pregnancy loss: a multivariate regression analysis

Glujovsky

Shamonki

Bergh

2007

Fertility and Sterility

View full text Add to dashboard Cite

Survival rates during the first trimester of multiple gestations achieved by ICSI: a report of 1448 consecutive multiples

Abstract: In multiple pregnancies there is a significant risk of spontaneous loss of any embryo during the first trimester. These findings should be considered prior to any decision about selective embryo reduction.

Cited by 20 publications

References 26 publications

Early pregnancy loss rates were different among singleton gestations conceived by ICSI using GnRH agonist and antagonist

Early pregnancy loss rates were different among singleton gestations conceived by ICSI using GnRH agonist and antagonist

Subclinical Pregnancy Losses Among Women Undergoing In-Vitro Fertilization With ICSI

Embryonic synergism may reduce pregnancy loss: a multivariate regression analysis

Contact Info

Product

Resources

About