Survival‑related DLEU1 is associated with HPV infection status and serves as a biomarker in HPV‑infected cervical cancer

Abstract

Human papillomavirus (HPV) is the most common risk factor for the occurrence of cervical cancer (cc). in recent years, the important roles of long non-coding rnas (lncrnas) in cc have emerged, but studies on the relationship between lncrnas and HPV-positive (HPV+) cc remain scarce. The present study aimed to investigate whether lncrna deleted in lymphocytic leukemia 1 (dleu1) is associated with HPV infection and explore the clinical significance of DLEU1 in HPV+ patients with cc. dleu1 expression was detected by reverse transcription-quantitative Pcr. The ability of dleu1 to screen patients with cc from controls and differentiate individuals with different HPV infection status was evaluated by receiver operating characteristic analysis. The association of dleu1 with the survival prognosis of patients with cc was assessed by Kaplan-Meier survival analysis and cox regression analysis. The rna interactome database was used to predict molecules interacting with dleu1. The results indicated that DLEU1 expression was significantly upregulated in CC tissues and cell lines, particularly in those that were HPV+. in addition, dleu1 had a high diagnostic value in discriminating patients with cc and differentiating between HPV+ and HPV-patients with cc, and had a certain ability to screen HPV+ controls. dleu1 was correlated with HPV infection in cc patients. Furthermore, dleu1 was indicated to be associated with survival prognosis in both total patients with cc and HPV+ patients with cc, and independently predict the prognosis of patients with cc. Most of the molecules interacting with dleu1 were micrornas. in conclusion, abnormal dleu1 expression is associated with HPV infection and may serve as a diagnostic and prognostic biomarker for HPV+ patients with cc.

An m1A/m6A/m5C‐associated long non‐coding RNA signature: Prognostic and immunotherapeutic insights into cervical cancer

“…Survival-related DLEU1 is a biomarker for HPV-infected CC and is connected to the presence of HPV infection. 74,75 Lv et al 76 selected immune-associated lncRNAs (including BOLA3-AS1) to build the risk model, risk scores were found to be inversely related to macrophage M1, macrophage M2, and t-cell CD8+. Lang et al 77 showed that the nine lncRNA signature (including AC004540.2) may be a promising predictive factor for CC and may help with the administration of medication in clinical practice.…”

“…By interacting with miR‐381 and enhancing HOXA13 expression in CC, DLEU1 promotes proliferation and invasion. Survival‐related DLEU1 is a biomarker for HPV‐infected CC and is connected to the presence of HPV infection 74,75 . Lv et al 76 selected immune‐associated lncRNAs (including BOLA3‐AS1) to build the risk model, risk scores were found to be inversely related to macrophage M1, macrophage M2, and t‐cell CD8+.…”

RIPOR2 Expression Decreased by HPV-16 E6 and E7 Oncoproteins: An Opportunity in the Search for Prognostic Biomarkers in Cervical Cancer

“…Previous efforts have been made to identify molecules that allow predicting the clinical outcome of CC patients, based on deregulated molecules in cancer [ 42 ], or on the presence and expression of viral oncogenes [ 43 ]. Although little information is available about those cellular elements deregulated by viral oncoproteins that could be used as biomarkers associated with clinical outcome in CC.…”

Value of high‑risk human papillomavirus detection combined with colposcopy in the diagnosis of cervical cancer and precancerous lesions

“…The early symptoms of patients are often ignored due to the lack of specificity; therefore, early cervical cancer screening is of value for the prevention of cervical cancer ( 6 ). Persistent infection with HR-HPV has been reported to be the main cause of cervical cancer ( 7 ). HR-HPV is a small double-stranded DNA virus that can cause skin and mucous membrane lesions in humans.…”