Survival, Short-Term, and Long-Term Morbidities of Neonates with Birth Weight &lt; 500 g

Bashir, Rani A.; Thomas, Julianne Petrie; MacKay, Margot; Agnew, J; Hubber-Richard, Philippa; Grunau, Ruth E.; Synnes, Anne

doi:10.1055/s-0037-1603462

Cited by 7 publications

(8 citation statements)

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“…In the literature, normal development is reported in a quarter to one‐third of survivors, 5 , 12 , 15 and survival without severe neurodevelopmental disability ranges from 27 to 71%. 5 , 12 , 13 , 15 , 27 Another factor possibly contributing to developmental delay might be the missing compensatory growth of head circumference until two years corrected age.…”

Section: Discussionmentioning

confidence: 99%

Considerable mortality and morbidity in neonates born below 500 gram

et al. 2021

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Section: Discussionmentioning

confidence: 99%

Considerable mortality and morbidity in neonates born below 500 gram

et al. 2021

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“…Severe ICH affected 12 of 63 infants (19%), while WMI affected 2 of 62 infants (3%). An ophthalmologic examination was performed in 29 of 71 in- 5 (3)(4)(5)(6)(7)(8)(9)(10) 4 (2-5) 6 (4-10) 46 (4-108) 5 (3-10) 5 (3-10) 4 (2-5) 6 (4-10) 46 (4-108) 5 (3)(4)(5)(6)(7)(8)(9)(10) Abbreviations: GA, gestational age; IQR, interquartile range. a Active treatment was defined as intubation, surfactant therapy, respiratory support, chest compressions, epinephrine, volume resuscitation, blood pressure support, or parenteral nutrition administration.…”

Section: Interventions and Morbidities During Hospitalizationmentioning

confidence: 99%

“…Early analyses reported poor survival for infants born with a BW less than 500 g. 2,3 Reports published since 2010 present improved short-term survival. [4][5][6][7][8][9] In Germany, Rieger-Fackeldey et al 4 found that 60% of liveborn infants with a BW of 500 g or less actively treated at birth survived to discharge. Keir et al 5 reported that 54% of infants with a BW of 500 g or less survived to discharge with active treatment in an Australian center; 43% had no or mild disability at 12 months' corrected age (CA).…”

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“…Pedley et al 6 found 64% survival to discharge for infants with a BW less than 500 g in a United Kingdom tertiary care unit. The California Perinatal Quality Care Collaborative recorded 21% survival for infants with a BW of 300-500 g. 7 In British Columbia, Canada, Bashir et al 8 reported 55% survival to discharge for infants admitted to intensive care with a BW less than 500 g; 27% had no impairment at 4 years. Nagara et al 9 found 80% survival with a BW less than 500 g in a Japanese case series; 5 of 7 infants (71%) had no or mild developmental disability at 3 years.…”

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Outcomes of Extremely Preterm Infants With Birth Weight Less Than 400 g

et al. 2019

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IMPORTANCE Birth weight (BW) is an important predictor of mortality and morbidity. At extremely early gestational ages (GAs), BW may influence decisions regarding initiation of resuscitation. OBJECTIVE To characterize outcomes of liveborn infants with a BW less than 400 g. DESIGN, SETTING, AND PARTICIPANTS This retrospective multicenter cohort study analyzed extremely preterm infants born between January 2008 and December 2016 within the National Institute of Child Health and Human Development Neonatal Research Network. Infants with a BW less than 400 g and a GA of 22 to 26 weeks were included. Active treatment was defined as the provision of any potentially lifesaving intervention after birth. Survival was analyzed for the entire cohort; neurodevelopmental impairment (NDI) was examined for those born between January 2008 and December 2015 (birth years with outcomes available for analysis). Neurodevelopmental impairment at 18 to 26 months' corrected age (CA) was defined as a Bayley Scales of Infant and Toddler Development, Third Edition, cognitive composite score less than 85, a motor composite score less than 85, moderate or severe cerebral palsy, gross motor function classification system score of 2 or greater, bilateral blindness, and/or hearing impairment. Data were analyzed from September 2017 to October 2018. EXPOSURES Birth weight less than 400 g. MAIN OUTCOMES AND MEASURES The primary outcome was survival to discharge among infants who received active treatment. Analysis of follow-up data was limited to infants born from 2008 to 2015 to ensure children had reached assessment age. Within this cohort, neurodevelopmental outcomes were assessed for infants who survived to 18 to 26 months' CA and returned for a comprehensive visit. RESULTS Of the 205 included infants, 121 (59.0%) were female, 133 (64.9%) were singletons, and 178 (86.8%) were small for gestational age. Almost half (101 of 205 [49.3%]) received active treatment at birth. A total of 26 of 205 infants (12.7%; 95% CI, 8.5-18.9) overall survived to discharge, and 26 of 101 actively treated infants (25.7%; 95% CI, 17.6-35.4) survived to discharge. Within the subset of infants with a BW less than 400 g and a GA of 22 to 23 weeks, 6 of 36 actively treated infants (17%; 95% CI, 6-33) survived to discharge. Among infants born between 2008 and 2015, 23 of 90 actively treated infants (26%; 95% CI, 17-36) survived to discharge. Two infants died after discharge, and 2 were lost to follow-up. Thus, 19 of 90 actively treated infants (21%; 95% CI, 13-31) were evaluated at 18 to 26 months' CA. Moderate or severe NDI occurred in 14 of 19 infants (74%). CONCLUSIONS AND RELEVANCE Infants born with a BW less than 400 g are at high risk of mortality and significant morbidity. Although 21% of infants survived to 18 to 26 months' CA with active treatment, NDI was common among survivors.

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“…Donošenje adekvatnih odluka u trenucima reanimacije, zatim donošenje odluka u toku dugog perioda lečenja i neonatalne zdravstvene nege veliki su izazov za zdravstveni tim, i utiču na procenat preživljavanja, morbiditet i neurorazvojne ishode prevremeno rođene dece. 8,9 Različiti koncepti ranih interventnih programa individualno prilagođenih svakom prevremeno rođenom detetu Da bi se poboljšali neurorazvojni ishodi prevremeno rođene dece, osamdesetih godina prošlog veka započeto je razvijanje nekoliko različitih interventnih programa. Jedan od interventnih programa koji je dobio podršku svetski priznatih stručnjaka u oblasti neonatologije i razvojne psihologije bio je "Neonatalna individualizovana razvojna nega i program procene" (engl.…”

Section: Pregledni Rad / Review Articleunclassified

Motor and cognitive abilities of children born before term

Smuđa¹,

Stojanović-Jovanović²,

Jovanović³

2020

PONS

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With the development of modern perinatal medicine and medical technology, the survival rate of premature infants has increased. However, premature birth is a risk factor for developmental delays. This paper evaluates the available literature to look at dominant developmental domains that reflect dysfunction of premature infants. Studies in which the subject of the study was to monitor the development of premature infants confirmed a lag in motor and cognitive development, and their interrelation. These results can be explained by: the early negative and unpleasant sensory experiences to which the immature nervous system was exposed ahead of time and the lack of adequate interaction of biological and environmental factors. Even after the prematurity has stabilized and with environmental stimuli that accelerate overall biological processes, many developments have been delayed. The first domain to identify developmental delays in premature infants is motor development. Studies show that babies born before 32 gestational weeks very often show persistent delays in motor development (gross and fine motor skills, perceptual-motor skills). Another domain that identifies developmental delays in premature infants is cognitive development. Empirical studies reveal that children under 26 weeks of gestational maturity show deficits or developmental delays in maintaining attention during the toddler period. Also, in these children, during the adolescence period, lower capacities of active and passive visual-spatial working memory were observed, which influences the acquisition of knowledge in mathematics, as well as the general achievement in school.

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Survival, Short-Term, and Long-Term Morbidities of Neonates with Birth Weight < 500 g

Cited by 7 publications

References 20 publications

Considerable mortality and morbidity in neonates born below 500 gram

Considerable mortality and morbidity in neonates born below 500 gram

Outcomes of Extremely Preterm Infants With Birth Weight Less Than 400 g

Motor and cognitive abilities of children born before term

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