Survival to patency of low level infections with<i>Trichuris muris</i>in mice concurrently infected with<i>Nematospiroides dubius</i>

Behnke, Jerzy M.; Ali, Najah M.H.; Jenkins, Simon N

doi:10.1080/00034983.1984.11811857

Cited by 31 publications

(12 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only two other studies on interactions with a Trichuris spp. have been reported; namely interactions between Trichuris muris and Nematospiroides dubius in mice by Behnke et al (1984). The changes in our study may relate to a delayed/reduced expulsion or better establishment of T. suis.…”

Section: Discussioncontrasting

confidence: 46%

Parasite population dynamics in pigs infected with Trichuris suis and Oesophagostomum dentatum

Petersen

Andreasen

Kringel

et al. 2014

Veterinary Parasitology

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 46%

Parasite population dynamics in pigs infected with Trichuris suis and Oesophagostomum dentatum

Petersen

Andreasen

Kringel

et al. 2014

Veterinary Parasitology

View full text Add to dashboard Cite

“…In helminth endemic countries it is common to observe that individuals are infected with multiple helminth species including multiple GI nematodes such as whipworm and hookworm [34] and a variety of laboratory co-infection studies have shown that infection by one species of GI nematode can affect the response to another [35–37], although always with single high doses of the respective parasites. In order to investigate the effect of a trickle T .…”

Section: Resultsmentioning

confidence: 99%

Trickle infection and immunity to Trichuris muris

et al. 2019

View full text Add to dashboard Cite

The majority of experiments investigating the immune response to gastrointestinal helminth infection use a single bolus infection. However, in situ individuals are repeatedly infected with low doses. Therefore, to model natural infection, mice were repeatedly infected (trickle infection) with low doses of Trichuris muris. Trickle infection resulted in the slow acquisition of immunity reflected by a gradual increase in worm burden followed by partial expulsion. Flow cytometry revealed that the CD4+ T cell response shifted from Th1 dominated to Th2 dominated, which coincided with an increase in Type 2 cytokines. The development of resistance following trickle infection was associated with increased worm expulsion effector mechanisms including goblet cell hyperplasia, Muc5ac production and increased epithelial cell turn over. Depletion of CD4+ T cells reversed resistance confirming their importance in protective immunity following trickle infection. In contrast, depletion of group 2 innate lymphoid cells did not alter protective immunity. T. muris trickle infection resulted in a dysbiotic mircrobiota which began to recover alpha diversity following the development of resistance. These data establish trickle infection as a robust and informative model for analysis of immunity to chronic intestinal helminth infection more akin to that observed under natural infection conditions and confirms the importance of CD4+ T cell adaptive immunity in host protection.

show abstract

“…This may be compatible with the idea that H. polygyrus predisposes mice to infection with T. muris through its immunomodulatory influence on the host. T. muris is known to elicit a strong host response in both laboratory mice and A. sylvaticus (Behnke & Wakelin 1973) and interactions between these species are well documented (Jenkins & Behnke 1977; Behnke, Ali & Jenkins 1984). However, further quantitative analysis of our field data by Spearman's test on raw data and on residuals of anova did not substantiate this association, but nevertheless provided some indication that heavier infections with H. polygyrus may be associated with heavier infections with T. muris .…”

Section: Discussionmentioning

confidence: 99%

Do the helminth parasites of wood mice interact?

Behnke

Gilbert

Abu-Madi

et al. 2005

Journal of Animal Ecology

Self Cite

107

View full text Add to dashboard Cite

Summary 1.Two published data sets of helminths of the wood mouse Apodemus sylvaticus (L.) were analysed to test the hypothesis that the structure of these component communities is influenced by interactions between species. A range of tests, with differing null models, was applied to tease out the importance of controlling for subgroupings (e.g. sex, age, site, year, season) within the data when searching for significant associations based on prevalence (co-occurrence, presence/absence) or abundance (quantitative associations) data. 2. Significant differences from null models were detected for associations based on prevalence, but when subgroup constraints were taken into consideration, most lost significance. Among three and 15 pair-wise associations possible in data sets 1 and 2, respectively, only that between Trichuris muris and Heligmosomoides polygyrus was not dependent on context, and that between H. polygyrus and Catenotaenia pusilla , while always positive, varied in magnitude among sites of capture. 3. Pair-wise comparisons of abundance revealed three significant associations, only one of which ( H. polygyrus with C. pusilla ) still remained significant after controlling for quantified extrinsic and intrinsic factors . With increasing burdens of H. polygyrus , mice carried more of other helminth species and this relationship remained significant after controlling for confounding factors. 4. Overall, positive co-occurrences of pairs of helminths of A. sylvaticus were highly context dependent and quantitative associations were weak and not convincing. Therefore, interactions between parasites are unlikely to play a dominant role among the processes that structure the component community of helminths in wood mice, in selected study sites in the south of England.

show abstract

Survival to patency of low level infections withTrichuris murisin mice concurrently infected withNematospiroides dubius

Cited by 31 publications

References 14 publications

Parasite population dynamics in pigs infected with Trichuris suis and Oesophagostomum dentatum

Parasite population dynamics in pigs infected with Trichuris suis and Oesophagostomum dentatum

Trickle infection and immunity to Trichuris muris

Do the helminth parasites of wood mice interact?

Contact Info

Product

Resources

About