Survival trends for small intestinal cancer in England and Wales, 1971–1990: national population-based study

Abstract

This population-based study examines prognostic factors and survival trends among adults (15 -99 years) diagnosed with small intestinal cancer in England and Wales during 1971 -1990 and followed up to 1995. During this period, the 1-and 5-year agestandardised relative survival rates for small intestinal cancers combined were 42% and 23%, respectively. Duodenal tumours, adenocarcinomas, men, patients with advanced age and the most deprived patients had the poorest prognosis. For all small bowel tumours combined, the excess risk of death fell significantly by 6 -9% every 4 years over the 20-year period (adjusted excess hazard ratio (EHR) 0.91 at 1 year after diagnosis, 0.94 at 5 years). For duodenal tumours, the EHR fell by about 14% (95% CI 5 -22%) every 4 years between 1979 and 1990, and a similar trend for jejunal tumours was of borderline significance. Further population-based investigations linking survival data to individual data on diagnostic methods and types of treatment are needed.

Complete Response of an Initially Non-surgical Adenocarcinoma of the Duodenum to Chemotherapy with the Folfox 4 Regimen

“…1,12,15,22 All studies report a better prognosis for jejunal or ileal adenocarcinomas than for duodenal adenocarcinomas, with 5-year survivals of 26-37.6%, 25-37.8%, and 15-28.2%, respectively. 13,15 Only half of the duodenal tumors in the literature were treated with cancer-directed surgery, versus 90% of jejunal and ileal tumors. These differences in treatment are probably due to anatomic constraints.…”

“…These differences in treatment are probably due to anatomic constraints. 13,15 In a large population study, curative resection was feasible in 56.6% of cases. 12 Few data are available about chemotherapy in palliative or adjuvant settings.…”

Cancers primitifs de l’intestin grêle: aspects épidémiologiques et diagnostiques au CHUYO: à propos de dix cas et revue de la littérature

“…Ils sont rares, alors que le grêle représente 70 à 80 % de la longueur du tube digestif et porte plus de 90 % de la surface muqueuse de l'ensemble du tube digestif [6,7].…”

“…Cependant, d'autres ont observé plutôt une prédominance masculine [11,12] ou une parité homme-femme [6,9]. La petite taille des échantillons en rapport avec la rareté de ce cancer ne permet pas de conclure à une prédominance masculine ou féminine.…”

“…Des âges moyens de 42 et 36 ans ont été observés respectivement au Togo et à Madagascar [4,7]. Cependant, l'âge moyen des patients dans les pays développés est supé-rieur à 60 ans [6,13,14]. Le cancer du grêle surviendrait plus précocement en Afrique par rapport aux pays riches [7].…”