Surviving a 10,000 mg overdose of clozapine: A case report

Survival of Combined Overdose with Very High Doses of Clozapine and Blonanserin: A Case Report

“…Absorption, however, must have been substantial because she was already in a confusional state two hours after the overdose. Despite this, we consider that the survival of our patient should not be construed as the safety of these drugs in overdose; for example, clozapine overdose has been associated with seizures, 7 rhabdomyolysis, 5 and death. 9 Lack of data on follow-up symptoms can be considered a limitation of the article.…”

“… 6 In this context, we had earlier reported a young woman who had survived a >10,000 mg overdose with clozapine. 7 We now report a second unsuccessful suicide attempt by this woman, which is unusual because of the combined use of very high doses of two antipsychotics. The patient’s consent was taken for publishing this article, and she was assured that her identity would not be revealed.…”

Abnormal blood concentration changes in a 71-year-old female who survived a 10,000mg overdose of clozapine: a case report

“…To our knowledge, this case is the oldest one to date that has survived treatment after taking such a recorded high dose. By exploring the reference database, some reports lacked continuous blood concentration results [ 15 ], others didn’t accurately quantify the levels, especially the upper limit level [ 16 ].…”