“Surviving and Thriving”: Evidence for Cortical GABA Stabilization in Cognitively-Intact Oldest-Old Adults
MK Britton,
G Jensen,
RA Edden
et al.
Abstract:Cortical GABA levels are reduced in older age; age-related differences in GABA may be associated with age-related cognitive change. The nature of age-related GABA differences in the highest-functioning stratum of the oldest-old (85+) population is not yet known. We extend our previously-reported Individual Participant Data Meta-Analysis of GABA levels (Porges et al., 2021) across the lifespan with four novel datasets sampling the cognitively-intact oldest-old. The slope of age-related GABA differences in cogni… Show more
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